Zobrazeno 1 - 10
of 191
pro vyhledávání: '"James W. McGinity"'
Publikováno v:
Drug Development and Industrial Pharmacy. 43:1421-1429
The overall objective of this study was to design and characterize the properties of a bioadhesive trilayer sustained-release implant device for the unidirectional local delivery of anticancer compounds to the brain following the removal of glioblast
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8ab175ad44992a6cd9aa5b60d7d89e1
https://doi.org/10.1080/03639045.2017.1318904
https://doi.org/10.1080/03639045.2017.1318904
Autor:
Justin S. LaFountaine, Robert O. Williams, Leena Kumari Prasad, Dave A. Miller, James W. McGinity
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 113:157-167
The oral delivery of mucoadhesive patches has been shown to enhance the absorption of large molecules such as peptides. We hypothesized that this mechanism could have utility for poorly soluble small molecules by utilizing a mucoadhesive polymer as t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7dec0179f5ed397fadfa5decc4ea441
https://doi.org/10.1016/j.ejpb.2016.12.031
https://doi.org/10.1016/j.ejpb.2016.12.031
Autor:
Dieter Lubda, Robert O. Williams, Chris Brough, Dave A. Miller, James W. McGinity, Justin S. LaFountaine, Leena Kumari Prasad, Scott V. Jermain
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 101:72-81
Polyvinyl alcohol has received little attention as a matrix polymer in amorphous solid dispersions (ASDs) due to its thermal and rheological limitations in extrusion processing and limited organic solubility in spray drying applications. Additionally
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b19b126456cf5c72884191cbd6a1750
https://doi.org/10.1016/j.ejpb.2016.01.018
https://doi.org/10.1016/j.ejpb.2016.01.018
Autor:
Robert O. Williams, Julien Maincent, Justin M. Keen, Leena Kumari Prasad, Justin S. LaFountaine, James W. McGinity
Publikováno v:
Journal of Drug Delivery Science and Technology. 30:501-510
An electrostatic powder deposition (ESPD) method was developed to prepare free films for drug delivery. Films were prepared using polyethylene oxide (PEO), a physical mixture of PEO and acetaminophen (APAP), and co-processed PEO and APAP particles. C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::344d05f947af72304565063d1d51347e
https://doi.org/10.1016/j.jddst.2015.08.011
https://doi.org/10.1016/j.jddst.2015.08.011
Autor:
Dave A. Miller, Robert O. Williams, Chris Brough, Justin S. LaFountaine, James W. McGinity, Leena Kumari Prasad
Publikováno v:
AAPS PharmSciTech. 17:120-132
Thermal processing technologies continue to gain interest in pharmaceutical manufacturing. However, the types and grades of polymers that can be utilized in common thermal processing technologies, such as hot-melt extrusion (HME), are often limited b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acaea5458cf345093df9aad4fb8a09b9
https://doi.org/10.1208/s12249-015-0417-7
https://doi.org/10.1208/s12249-015-0417-7
Autor:
Justin M. Keen, Daniel J. Ellenberger, Dave A. Miller, James W. McGinity, Robert O. Williams, Chris Brough, Marshall Cisneros
Publikováno v:
Journal of Pharmacy and Pharmacology. 68:678-691
Objectives To evaluate the effect of ritonavir (RTV) co-administration on the bioavailability of an amorphous dispersion of acetyl-11-keto-beta-boswellic acid (AKBA) and to develop a pharmaceutically acceptable AKBA–RTV combination tablet. Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96e40a336fda0f91b62a489c2e29672b
https://doi.org/10.1111/jphp.12478
https://doi.org/10.1111/jphp.12478
Autor:
Mark A. Rickard, Siyuan Huang, Justin M. Keen, Kevin P. O’Donnell, James W. McGinity, Robert O. Williams
Publikováno v:
AAPS PharmSciTech. 17:106-119
Hypromellose is a hydrophilic polymer widely used in immediate- and modified-release oral pharmaceutical dosage forms. However, currently available grades of hypromellose are difficult, if not impossible, to process by hot melt extrusion (HME) becaus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10442536f6a294ad118eddd0be94c5de
https://doi.org/10.1208/s12249-015-0395-9
https://doi.org/10.1208/s12249-015-0395-9
Publikováno v:
AAPS PharmSciTech. 17:43-55
Thermal processing of amorphous solid dispersions continues to gain interest in the pharmaceutical industry, as evident by several recently approved commercial products. Still, a number of pharmaceutical polymer carriers exhibit thermal or viscoelast
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9172c2bf6c4be5324d1d500a48eee4e
https://doi.org/10.1208/s12249-015-0393-y
https://doi.org/10.1208/s12249-015-0393-y
Autor:
Justin M. Keen, James W. McGinity, Justin R. Hughey, Vincent Jannin, Ryan C. Bennett, Connor J. Foley, Yvonne Rosiaux, Delphine Marchaud
Publikováno v:
International Journal of Pharmaceutics. 487:72-80
Interest in granulation processes using twin screw extrusion machines is rapidly growing. The primary objectives of this study were to develop a continuous granulation process for direct production of granules using this technique with glyceryl behen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6174d0a71595d6fb131e6e4e3e15853
https://doi.org/10.1016/j.ijpharm.2015.03.058
https://doi.org/10.1016/j.ijpharm.2015.03.058
Publikováno v:
Drug Development and Industrial Pharmacy. 41:1294-1301
While the use of amorphous solid dispersions to improve aqueous solubility is well documented, little consideration has traditionally been given to the finished dosage form. The objective of this study was to evaluate the dissolution performance of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::504685025a2ae169c14b6cd0dd62d6ef
https://doi.org/10.3109/03639045.2014.947508
https://doi.org/10.3109/03639045.2014.947508