Zobrazeno 1 - 10
of 16
pro vyhledávání: '"James W. Jetter"'
Autor:
James W. Jetter
Publikováno v:
Journal of Chemical Education. 87:908-911
This review of Science Projects, How To Collect, Analyze, and Present Your Data and related titles synopsizes the contents and uses for these books, offering a hearty endorsement of their worth.
Autor:
Baihua Hu, Elaine Quinet, Irene Feingold, Igor Goljer, Thomas J. Berrodin, Mark J. Evans, James W Jetter, Jay Wrobel, Rayomand J. Unwalla, Michael D Basso, Annika Goos Nilsson, Anna Wilhelmsson
Publikováno v:
Journal of Medicinal Chemistry. 53:3296-3304
A series of phenyl sulfone substituted quinoxaline were prepared and the lead compound 13 (WYE-672) was shown to be a tissue selective LXR Agonist. Compound 13 demonstrated partial agonism for LXRbeta in kidney HEK-293 cells but did not activate Gal4
Autor:
William R. Adams, Irene Feingold, John F. Mehlmann, Cesario O Tio, Joshua E. Cottom, Jay E. Wrobel, Jeffrey C. Pelletier, Daniel M. Green, John F. Rogers, James W. Jetter, Murty Chengalvala, Joseph T. Lundquist, Charles William Mann, Linda Shanno, Ronald L. Magolda, Diane B. Hauze, Gregory S. Kopf, Christine Huselton
Publikováno v:
Journal of Medicinal Chemistry. 52:2148-2152
A potent, highly insoluble, GnRH antagonist with a 2-phenyl-4-piperazinylbenzimidazole template and a quinoxaline-2,3-dione pharmacophore was modified to maintain GnRH antagonist activity and improve in vitro pharmaceutical properties. Structural cha
Autor:
Murty V. Chengalvala, Linda Shanno, Charles William Mann, Josh Cottom, Diane B. Hauze, Jay E. Wrobel, Irene Feingold, Jeffrey C. Pelletier, Gregory S. Kopf, Daniel M. Green, John A. Rogers, Wenling Kao, Christine Huselton, John F. Mehlmann, Joseph T. Lundquist, Lloyd M. Garrick, James W. Jetter
Publikováno v:
Bioorganic & Medicinal Chemistry. 16:6617-6640
Antagonism of the gonadotropin releasing hormone (GnRH) receptor has shown positive clinical results in numerous reproductive tissue disorders such as endometriosis, prostate cancer and others. Traditional therapy has been limited to peptide agonists
Autor:
Jill L. Hardenburg, John Rogers, Darlene C. Deecher, Francisco J. López, Emily S. Shen, Brian J. Arey, Jay Wrobel, James W Jetter, M. Claudia Perez, Daniel M. Green, Wenling Kao
Publikováno v:
Bioorganic & Medicinal Chemistry. 10:639-656
Screening efforts identified (bis)sulfonic acid, (bis)benzamides (1-3) as compounds that interact with the follicle stimulating-hormone receptor (FSHR) and inhibit FSH-stimulated cAMP accumulation with IC(50) values in the low micromolar range. Struc
Autor:
James W. Jetter
Publikováno v:
Journal of Chemical Education. 87:584-586
This article presents a review of the textbook titled Organic Chemistry, 5th edition by Marc Loudon. This textbook is recommended for use in a full-year (two-semester) undergraduate organic chemistry course.
Autor:
Patricia P Harlow, Solomon Ka, Smallheer Jm, Martha H. Corjay, Ruth R. Wexler, Pitts William J, Prabhakar K. Jadhav, Shaker A. Mousa, Buynitsky Js, John Wityak, James W. Jetter, Tobin Ae
Publikováno v:
Journal of Medicinal Chemistry. 43:27-40
Starting with lead compound 2, we sought to increase the selectivity for αvβ3-mediated cell adhesion by examining the effects of structural changes in both the guanidine mimetic and the substituent α to the carboxylate. To prepare some of the desi
Autor:
James W. Jetter, James M. Trzaskos, Ronald L. Magolda, Pitts William J, Shuaige Wang, Michael J. Orwat, Susan R. Sherk, Gregory C. Houghton, Maryanne B. Covington, Douglas G. Batt, Donald J. P. Pinto, Joseph J. Petraitis, Robert A. Copeland
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 9:919-924
The discovery of terphenyl derivatives as highly selective COX-2 inhibitors resulted from our efforts to overcome poor pharmacokinetics demonstrated by the COX-2 selective diarylthiophene DuP 697 [2-bromo-4-(4′-sulfonylmethyl)phenyl-5-(4′-fluoro)
Autor:
Douglas G. Batt, Elizabeth A. Jones, Donald J. P. Pinto, Pitts William J, Joseph J. Petraitis, Susan R. Sherk, Michael J. Orwat, Robert A. Copeland, Bruce D. Jaffee, Ronald L. Magolda, Randine L. Dowling, Tracy L. Gardner, Irina Cipora Jacobson, James W. Jetter
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 8:307-312
The structure-activity relationships of some tetracyclic heterocycles related to Brequinar were explored. Activities as inhibitors of dihydroorotate dehydrogenase and the mixed lymphocyte reaction are related to ring system, heteroatom placement, and
Autor:
Ronald C. Bernotas, Irene Feingold, James W. Jetter, Christofer Enroth, Anna Wilhelmsson, Robert W Morris, Christine Huselton, Annika Goos-Nilsson, John W. Ullrich, Jay E. Wrobel, Ponnal Nambi, Elaine Quinet, Rayomand J. Unwalla, Jeremy M. Travins
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(9)
A series of 4-(3-biaryl)quinolines with sulfone substituents on the terminal aryl ring (8) was prepared as potential LXR agonists. High affinity LXRbeta ligands with generally modest binding selectivity over LXRalpha and excellent agonist potency in