Disruption of white matter connectivity in chronic obstructive pulmonary disease.

Autor: Catherine A Spilling, Paul W Jones, James W Dodd, Thomas R Barrick

Publikováno v: PLoS ONE, Vol 14, Iss 10, p e0223297 (2019)

BACKGROUND:Mild cognitive impairment is a common systemic manifestation of chronic obstructive pulmonary disease (COPD). However, its pathophysiological origins are not understood. Since, cognitive function relies on efficient communication between d

Externí odkaz: https://doaj.org/article/71301f95753d433d84585cfd1318bd27

White matter lesions characterise brain involvement in moderate to severe chronic obstructive pulmonary disease, but cerebral atrophy does not

Autor: Catherine A. Spilling, Paul W. Jones, James W. Dodd, Thomas R. Barrick

Publikováno v: BMC Pulmonary Medicine, Vol 17, Iss 1, Pp 1-12 (2017)

Abstract Background Brain pathology is relatively unexplored in chronic obstructive pulmonary disease (COPD). This study is a comprehensive investigation of grey matter (GM) and white matter (WM) changes and how these relate to disease severity and c

Externí odkaz: https://doaj.org/article/679fc42ac68046a0a1b3f0c3f64eaaaa

Lung function, COPD and cognitive function: a multivariable and two sample Mendelian randomization study

Autor: Raquel Granell, Gibran Hemani, George Davey Smith, Daniel H Higbee, James W. Dodd

Publikováno v: BMC Pulmonary Medicine, Vol 21, Iss 1, Pp 1-7 (2021)
BMC Pulmonary Medicine
Higbee, D H, Granell, R, Hemani, G, Davey Smith, G & Dodd, J 2021, ' Lung function, COPD and cognitive function: a multivariable and two sample Mendelian randomization study ', BMC Pulmonary Medicine, vol. 21, no. 1, 246 . https://doi.org/10.1186/s12890-021-01611-6

Background Observational studies show an association between reduced lung function and impaired cognition. Cognitive dysfunction influences important health outcomes and is a precursor to dementia, but treatments options are currently very limited. A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e79a5d1560d93260a9e576385ec9ce6
https://doaj.org/article/c7cc5c5f7c1546d89535b4c5dd299edf

Biologic therapy practices in severe asthma; outcomes from the UK Severe Asthma Registry and survey of specialist opinion

Autor: Adel H, Mansur, Sherif, Gonem, Thomas, Brown, Hassan, Burhan, Rekha, Chaudhuri, James W, Dodd, Thomas, Pantin, Robin, Gore, David, Jackson, Andrew, Menzies-Gow, Mitesh, Patel, Ian, Pavord, Paul, Pfeffer, Salman, Siddiqui, John, Busby, Liam G, Heaney, Deepak, Subramanian

Publikováno v: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

several biological treatments have become available for management of severe asthma. There is a significant overlap in the indication of these treatments with lack of consensus on the first-line biologic choice and switching practice in event of trea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d1655bfd4465492f406376b351ae4ff
https://pubmed.ncbi.nlm.nih.gov/36057784

Prevalence, risk factors, and clinical implications of preserved ratio impaired spirometry:a UK Biobank cohort analysis

Autor: George Davey Smith, James W. Dodd, Daniel H Higbee, Raquel Granell

Publikováno v: Higbee, D H, Granell, R, Davey Smith, G & Dodd, J 2022, ' Prevalence, risk factors, and clinical implications of preserved ratio impaired spirometry : a UK Biobank cohort analysis ', Lancet Respiratory Medicine, vol. 10, no. 2, pp. 149-157 . https://doi.org/10.1016/S2213-2600(21)00369-6

BackgroundPreserved ratio impaired spirometry (PRISm) is defined as a FEV1 of less than 80% predicted and a FEV1/forced vital capacity (FVC) ratio of 0·70 or higher. Previous research has indicated that PRISm is associated with respiratory symptoms

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c1c4b5402daf5a3f4d40e57ecba4c2d
https://research-information.bris.ac.uk/ws/files/305016785/PRISm_paper_LRM_second_revisions_clean_copy_endnote_intact_2_.pdf