Zobrazeno 1 - 10
of 265
pro vyhledávání: '"James W Dennis"'
Autor:
Sung-Uk Lee, Carey F Li, Christie-Lynn Mortales, Judy Pawling, James W Dennis, Ani Grigorian, Michael Demetriou
Publikováno v:
PLoS ONE, Vol 14, Iss 3, p e0214253 (2019)
N-acetylglucosamine (GlcNAc) branching of Asn (N)-linked glycans inhibits pro-inflammatory T cell responses and models of autoimmune diseases such as Multiple Sclerosis (MS). Metabolism controls N-glycan branching in T cells by regulating de novo hex
Externí odkaz:
https://doaj.org/article/60517fbf723743b2b183094b3a13e13c
Autor:
Jyothsna Chitturi, Wesley Hung, Anas M Abdel Rahman, Min Wu, Maria A Lim, John Calarco, Renee Baran, Xun Huang, James W Dennis, Mei Zhen
Publikováno v:
PLoS Genetics, Vol 14, Iss 4, p e1007303 (2018)
UBR1 is an E3 ubiquitin ligase best known for its ability to target protein degradation by the N-end rule. The physiological functions of UBR family proteins, however, remain not fully understood. We found that the functional loss of C. elegans UBR-1
Externí odkaz:
https://doaj.org/article/41e7ddb2774043c3a19a4f785964a3e6
Autor:
Joseph Veyhl, Robert J Dunn, Wendy L Johnston, Alexa Bennett, Lijia W Zhang, James W Dennis, Harry Schachter, Joseph G Culotti
Publikováno v:
PLoS ONE, Vol 12, Iss 8, p e0183049 (2017)
Glycoproteins such as growth factor receptors and extracellular matrix have well-known functions in development and cancer progression, however, the glycans at sites of modification are often heterogeneous molecular populations which makes their func
Externí odkaz:
https://doaj.org/article/0a3cd235050f44908f27406dc15e0633
Autor:
Ryan Williams, Xiangyuan Ma, Ryan K Schott, Naveed Mohammad, Chi Yip Ho, Carey F Li, Belinda S W Chang, Michael Demetriou, James W Dennis
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e86088 (2014)
Protein N-glycosylation is found in all domains of life and has a conserved role in glycoprotein folding and stability. In animals, glycoproteins transit through the Golgi where the N-glycans are trimmed and rebuilt with sequences that bind lectins,
Externí odkaz:
https://doaj.org/article/61249263399a4b6c95dd469886afc427
Autor:
Michael Sy, Barbara L. Newton, Judy Pawling, Ken L. Hayama, Andres Cordon, Zhaoxia Yu, Jens Kuhle, James W. Dennis, Alexander U. Brandt, Michael Demetriou
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-14 (2023)
Abstract Background In the demyelinating disease multiple sclerosis (MS), chronic-active brain inflammation, remyelination failure and neurodegeneration remain major issues despite immunotherapy. While B cell depletion and blockade/sequestration of T
Externí odkaz:
https://doaj.org/article/26ed65cec5fb49f382b672413fb8685d
Autor:
Reza Beheshti Zavareh, Mahadeo A Sukhai, Rose Hurren, Marcela Gronda, Xiaoming Wang, Craig D Simpson, Neil Maclean, Francis Zih, Troy Ketela, Carol J Swallow, Jason Moffat, David R Rose, Harry Schachter, Aaron D Schimmer, James W Dennis
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e43721 (2012)
Oncogenic signaling promotes tumor invasion and metastasis, in part, by increasing the expression of tri- and tetra- branched N-glycans. The branched N-glycans bind to galectins forming a multivalent lattice that enhances cell surface residency of gr
Externí odkaz:
https://doaj.org/article/76ee1fcc2d2a4fbda66813266fae872d
Autor:
Myrto Barmpouni, Jason P. Gordon, Ryan L. Miller, James W. Dennis, Vassilis Grammelis, Aris Rousakis, Kyriakos Souliotis, Garyphallia Poulakou, George L. Daikos, Amer Al-Taie
Publikováno v:
Infectious Diseases and Therapy, Vol 12, Iss 7, Pp 1891-1905 (2023)
Abstract Introduction Antimicrobial resistance (AMR) is a major public health threat worldwide. Greece has the highest burden of infections due to antibiotic-resistant bacteria among European Union/European Economic Area (EU/EEA) countries. One of th
Externí odkaz:
https://doaj.org/article/71189e6ae06c459eb03f0a3f496ecb81
Autor:
Jason P. Gordon, Amer Al Taie, Ryan L. Miller, James W. Dennis, Mark A. T. Blaskovich, Jonathan R. Iredell, John D. Turnidge, Geoffrey W. Coombs, David Charles Grolman, Jacqueline Youssef
Publikováno v:
Infectious Diseases and Therapy, Vol 12, Iss 7, Pp 1875-1889 (2023)
Abstract Introduction Antimicrobial resistance (AMR) is a global public health challenge requiring a global response to which Australia has issued a National Antimicrobial Resistance Strategy. The necessity for continued-development of new effective
Externí odkaz:
https://doaj.org/article/24afa07774464f74bd27b49a88271d34
Autor:
Myrto Barmpouni, Jason P. Gordon, Ryan L. Miller, Clive R. J. Pritchard, James W. Dennis, Vassilis Grammelis, Aris Rousakis, Kyriakos Souliotis, Garyphallia Poulakou, George L. Daikos, Amer Al-Taie
Publikováno v:
Infectious Diseases and Therapy, Vol 12, Iss 2, Pp 527-543 (2022)
Plain Language Summary Antimicrobial resistance is a major issue for the Greek healthcare system. The overuse of antibacterial agents contributes to the growing resistance levels, making currently available treatment options less effective. As a resu
Externí odkaz:
https://doaj.org/article/2c0f031702644fdfaa67e4e02137a13a
Autor:
Connor Yanchus, Kristen L. Drucker, Thomas M. Kollmeyer, Ricky Tsai, Warren Winick-Ng, Minggao Liang, Ahmad Malik, Judy Pawling, Silvana B. De Lorenzo, Asma Ali, Paul A. Decker, Matt L. Kosel, Arijit Panda, Khalid N. Al-Zahrani, Lingyan Jiang, Jared W. L. Browning, Chris Lowden, Michael Geuenich, J. Javier Hernandez, Jessica T. Gosio, Musaddeque Ahmed, Sampath Kumar Loganathan, Jacob Berman, Daniel Trcka, Kulandaimanuvel Antony Michealraj, Jerome Fortin, Brittany Carson, Ethan W. Hollingsworth, Sandra Jacinto, Parisa Mazrooei, Lily Zhou, Andrew Elia, Mathieu Lupien, Housheng Hansen He, Daniel J. Murphy, Liguo Wang, Alexej Abyzov, James W. Dennis, Philipp G. Maass, Kieran Campbell, Michael D. Wilson, Daniel H. Lachance, Margaret Wrensch, John Wiencke, Tak Mak, Len A. Pennacchio, Diane E. Dickel, Axel Visel, Jeffrey Wrana, Michael D. Taylor, Gelareh Zadeh, Peter Dirks, Jeanette E. Eckel-Passow, Liliana Attisano, Ana Pombo, Cristiane M. Ida, Evgeny Z. Kvon, Robert B. Jenkins, Daniel Schramek
Publikováno v:
Science
Establishing causal links between inherited polymorphisms and cancer risk is challenging. Here, we focus on the single-nucleotide polymorphism rs55705857, which confers a sixfold greater risk of isocitrate dehydrogenase ( IDH) –mutant low-grade gli