Zobrazeno 1 - 10
of 193
pro vyhledávání: '"James W Dear"'
Autor:
James W Dear, Mei Li Ng, D. Nicholas Bateman, Pakkiri Leroy Sivappiragasam, Hyungwon Choi, Benjamin Bing Jie Khoo, Baharudin Ibrahim, Chester Lee Drum
Publikováno v:
Clinical and Translational Science, Vol 14, Iss 4, Pp 1476-1489 (2021)
Abstract N‐acetylcysteine (NAC) is an antidote to prevent acetaminophen (paracetamol‐APAP)‐induced acute liver injury (ALI). The 3‐bag licensed 20.25 h standard regimen, and a 12 h modified regimen, are used to treat APAP overdose. This study
Externí odkaz:
https://doaj.org/article/c0d39898714f4beaa8543632ec0545ce
Autor:
David M Rissin, Barbara López-Longarela, Salvatore Pernagallo, Hugh Ilyine, A D Bastiaan Vliegenthart, James W Dear, Juan J Díaz-Mochón, David C Duffy
Publikováno v:
PLoS ONE, Vol 12, Iss 7, p e0179669 (2017)
We have developed a single probe method for detecting microRNA from human serum using single molecule arrays, with sequence specificity down to a single base, and without the use of amplification by polymerases. An abasic peptide nucleic acid (PNA) p
Externí odkaz:
https://doaj.org/article/06f0f8682210475f9dba71838795e9f1
Autor:
Susan K. Armstrong, Robert W. Hunter, Wilna Oosthyuzen, Maciej Parys, Adam G. Gow, Silke Salavati Schmitz, James W. Dear, Richard J. Mellanby
Publikováno v:
Journal of Veterinary Internal Medicine, Vol 38, Iss 2, Pp 995-1004 (2024)
Abstract Background Pancreatitis is an important cause of disease and death in dogs. Available circulating biomarkers are not sufficiently sensitive and specific for a definitive diagnosis. Hypothesis Circulating microRNAs would be differentially exp
Externí odkaz:
https://doaj.org/article/913d36e6a492448987a96443eb56e317
Autor:
Tariq E. Farrah, Dan Pugh, Fiona A. Chapman, Emily Godden, Craig Balmforth, Gabriel C. Oniscu, David J. Webb, Baljean Dhillon, James W. Dear, Matthew A. Bailey, Peter J. Gallacher, Neeraj Dhaun
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract In patients with chronic kidney disease (CKD), there is an unmet need for novel biomarkers that reliably track kidney injury, demonstrate treatment-response, and predict outcomes. Here, we investigate the potential of retinal optical coheren
Externí odkaz:
https://doaj.org/article/c6fc4eec224e416b98d9113a9b9e3588
Autor:
Kodihalli C. Ravindra, Vishal S. Vaidya, Zhenyu Wang, Joel D. Federspiel, Richard Virgen-Slane, Robert A. Everley, Jane I. Grove, Camilla Stephens, Mireia F. Ocana, Mercedes Robles-Díaz, M. Isabel Lucena, Raul J. Andrade, Edmond Atallah, Alexander L. Gerbes, Sabine Weber, Helena Cortez-Pinto, Andrew J. Fowell, Hyder Hussaini, Einar S. Bjornsson, Janisha Patel, Guido Stirnimann, Sumita Verma, Ahmed M. Elsharkawy, William J. H. Griffiths, Craig Hyde, James W. Dear, Guruprasad P. Aithal, Shashi K. Ramaiah
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Diagnosis of rare, unpredictable, drug-induced liver injury (DILI) is a significant challenge for patients, clinicians, and drug development. Here, the authors discover, evaluate, and validate potential blood biomarkers to diagnose DILI and distingui
Externí odkaz:
https://doaj.org/article/ec3315a517864777bd5bdde19a8b8aa2
Autor:
Emma E. Morrison, Katherine Oatey, Bernadette Gallagher, Julia Grahamslaw, Rachel O'Brien, Polly Black, Wilna Oosthuyzen, Robert J. Lee, Christopher J. Weir, Dennis Henriksen, James W. Dear
Publikováno v:
EBioMedicine, Vol 46, Iss , Pp 423-430 (2019)
Background: The POP Trial was a phase 1, open-label, rising-dose, randomised study that explored the safety and tolerability of calmangafodipir (superoxide dismutase mimetic) co-treatment with n-acetylcysteine (NAC) for paracetamol overdose. Methods:
Externí odkaz:
https://doaj.org/article/8634f94b06b647bf93d8be5200422d32
Autor:
Janice M. Pettie, Thomas M. Caparrotta, Robert W. Hunter, Emma E. Morrison, David M. Wood, Paul I. Dargan, Ruben H. Thanacoody, Simon H.L. Thomas, Muhammad E.M.O. Elamin, Ben Francis, David J. Webb, Euan A. Sandilands, Michael Eddleston, James W. Dear
Publikováno v:
EClinicalMedicine, Vol 11, Iss , Pp 11-17 (2019)
Background: Acetylcysteine (NAC) is effective at preventing liver injury after paracetamol overdose. The Scottish and Newcastle Anti-emetic Pre-treatment for Paracetamol Poisoning (SNAP) Study demonstrated that a 12 h NAC regimen was associated with
Externí odkaz:
https://doaj.org/article/703ead76032c47ca9dbd0a31d1676094
Autor:
Sarath K. Channavajjhala, Roger Bramley, Theresa Peltz, Wilna Oosthuyzen, Wenjing Jia, Sue Kinnear, Barry Sampson, Nick Martin, Ian P. Hall, Matthew A. Bailey, James W. Dear, Mark Glover
Publikováno v:
Kidney International Reports, Vol 4, Iss 1, Pp 139-147 (2019)
Introduction: Thiazide diuretics are among the most widely used antihypertensive medications worldwide. Thiazide-induced hyponatremia (TIH) is 1 of their most clinically significant adverse effects. A priori TIH must result from excessive saliuresis
Externí odkaz:
https://doaj.org/article/5519471582a8414b83786aefcd294c59
Autor:
Erin E. Gaughan, Tom M. Quinn, Andrew Mills, Annya M. Bruce, Jean Antonelli, Alison C. MacKinnon, Vassilios Aslanis, Feng Li, Richard O’Connor, Cecilia Boz, Ross Mills, Philip Emanuel, Matthew Burgess, Giulia Rinaldi, Asta Valanciute, Bethany Mills, Emma Scholefield, Gareth Hardisty, Emily Gwyer Findlay, Richard A. Parker, John Norrie, James W. Dear, Ahsan R. Akram, Oliver Koch, Kate Templeton, David H. Dockrell, Timothy S. Walsh, Stephen Partridge, Duncan Humphries, Jie Wang-Jairaj, Robert J. Slack, Hans Schambye, De Phung, Lise Gravelle, Bertil Lindmark, Manu Shankar-Hari, Nikhil Hirani, Tariq Sethi, Kevin Dhaliwal
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 207:138-149
Autor:
Tariq E. Farrah, Vanessa Melville, Alicja Czopek, Henry Fok, Lorraine Bruce, Nicholas L. Mills, Matthew A. Bailey, David J. Webb, James W. Dear, Neeraj Dhaun
Publikováno v:
Farrah, T E, Melville, V, Czopek, A, Fok, H, Bruce, L, Mills, N L, Bailey, M A, Webb, D J, Dear, J W & Dhaun, N 2022, ' Arterial stiffness, endothelial dysfunction and impaired fibrinolysis are pathogenic mechanisms contributing to cardiovascular risk in ANCA-associated vasculitis ', Kidney International, vol. 102, pp. 1115-1126 . https://doi.org/10.1016/j.kint.2022.07.026
Cardiovascular disease is a complication of systemic inflammatory diseases and anti-neutrophil cytoplasm antibody-associated vasculitis (AAV) is an exemplar. Mechanisms are poorly understood, and risk-reduction strategies are lacking.In a series of d