Toward a Rapid Production of Multivirus-Specific T Cells Targeting BKV, Adenovirus, CMV, and EBV from Umbilical Cord Blood

Autor: Elizabeth J. Shpall, James W Blaney, Patrick J. Hanley, Conrad Russell Y. Cruz, Shabnum Patel, Cecilia Barese, Min Luo, Catherine M. Bollard, Hema Dave

Publikováno v: Molecular Therapy: Methods & Clinical Development, Vol 5, Iss C, Pp 13-21 (2017)
Molecular Therapy. Methods & Clinical Development

Umbilical cord blood (CB) has emerged as an effective alternative donor source for hematopoietic stem cell transplantation. Despite this success, the prolonged duration of immune suppression following CB transplantation and the naiveté of CB T cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::755291ca92ce148562fdeaaf445316af
http://www.sciencedirect.com/science/article/pii/S2329050117300414

CMV-specific T cells generated from naïve T cells recognize atypical epitopes and may be protective in vivo

Autor: Kathryn S. Leung, Sharon Lam, Helen E. Heslop, Elizabeth J. Shpall, Cliona M. Rooney, Sarah Nikiforow, Hao Liu, Phillip Scheinberg, Caridad Martinez, Catherine M. Bollard, Gail J. Demmler-Harrison, John R. Rodgers, Patrick J. Hanley, J. Joseph Melenhorst, Robert A. Krance, C. Russell Cruz, James W Blaney, Daniel C. Douek, A. John Barrett

Publikováno v: Science Translational Medicine. 7

Adoptive transfer of cytomegalovirus (CMV)-specific T cells derived from adult seropositive donors can effectively restore antiviral immunity after transplantation. However, CMV-seronegative donors lack CMV-specific memory T cells, which restricts th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afa54ff48bdb43575acf8b38197b0634
https://doi.org/10.1126/scitranslmed.aaa2546

The effects of age and latent cytomegalovirus infection on the redeployment of CD8+ T cell subsets in response to acute exercise in humans

Autor: Hanspeter Pircher, Catherine M. Bollard, Richard J. Simpson, Patrick J. Hanley, Emily C. LaVoy, James W Blaney, Austin B. Bigley, Guillaume Spielmann

Publikováno v: Brain, behavior, and immunity. 39

Dynamic exercise evokes a rapid redeployment of cytotoxic T cell subsets with high expression of β2 adrenergic receptors, presumably to enhance immunosurveillance during acute stress. As this response is affected by age and infection history, this s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::511c09a2b8b26bef77fd1f6c536b63c9
https://pubmed.ncbi.nlm.nih.gov/23684819