Výsledky vyhledávání - "James W Blaney"

Toward a Rapid Production of Multivirus-Specific T Cells Targeting BKV, Adenovirus, CMV, and EBV from Umbilical Cord Blood

Autor: Elizabeth J. Shpall, James W Blaney, Patrick J. Hanley, Conrad Russell Y. Cruz, Shabnum Patel, Cecilia Barese, Min Luo, Catherine M. Bollard, Hema Dave

Publikováno v: Molecular Therapy: Methods & Clinical Development, Vol 5, Iss C, Pp 13-21 (2017)
Molecular Therapy. Methods & Clinical Development

Umbilical cord blood (CB) has emerged as an effective alternative donor source for hematopoietic stem cell transplantation. Despite this success, the prolonged duration of immune suppression following CB transplantation and the naiveté of CB T cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::755291ca92ce148562fdeaaf445316af
http://www.sciencedirect.com/science/article/pii/S2329050117300414

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CMV-specific T cells generated from naïve T cells recognize atypical epitopes and may be protective in vivo

Autor: Kathryn S. Leung, Sharon Lam, Helen E. Heslop, Elizabeth J. Shpall, Cliona M. Rooney, Sarah Nikiforow, Hao Liu, Phillip Scheinberg, Caridad Martinez, Catherine M. Bollard, Gail J. Demmler-Harrison, John R. Rodgers, Patrick J. Hanley, J. Joseph Melenhorst, Robert A. Krance, C. Russell Cruz, James W Blaney, Daniel C. Douek, A. John Barrett

Publikováno v: Science Translational Medicine. 7

Adoptive transfer of cytomegalovirus (CMV)-specific T cells derived from adult seropositive donors can effectively restore antiviral immunity after transplantation. However, CMV-seronegative donors lack CMV-specific memory T cells, which restricts th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afa54ff48bdb43575acf8b38197b0634
https://doi.org/10.1126/scitranslmed.aaa2546

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A single bout of dynamic exercise enhances the expansion of MAGE-A4 and PRAME-specific cytotoxic T-cells from healthy adults

Autor: Emily C P, LaVoy, Catherine M, Bollard, Patrick J, Hanley, James W, Blaney, Daniel P, O'Connor, Jos A, Bosch, Richard J, Simpson

Publikováno v: Exercise immunology review. 21

The ex vivo expansion of tumor-associated-antigen (TAA)- specific cytotoxic T-cells (CTLs) from healthy donors for adoptive transfer to cancer patients is now providing additional treatment options for patients. Many studies have shown that adoptive

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::b4c6bad7a2f1499befbc635db4a768cc
https://pubmed.ncbi.nlm.nih.gov/25826370

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The effects of age and latent cytomegalovirus infection on the redeployment of CD8+ T cell subsets in response to acute exercise in humans

Autor: Hanspeter Pircher, Catherine M. Bollard, Richard J. Simpson, Patrick J. Hanley, Emily C. LaVoy, James W Blaney, Austin B. Bigley, Guillaume Spielmann

Publikováno v: Brain, behavior, and immunity. 39

Dynamic exercise evokes a rapid redeployment of cytotoxic T cell subsets with high expression of β2 adrenergic receptors, presumably to enhance immunosurveillance during acute stress. As this response is affected by age and infection history, this s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::511c09a2b8b26bef77fd1f6c536b63c9
https://pubmed.ncbi.nlm.nih.gov/23684819

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111. A single bout of exercise improves the expansion of cytotoxic T-cells specific to melanoma antigens in healthy humans: Implications for adoptive transfer immunotherapy

Autor: Patrick J. Hanley, Emily C. LaVoy, James W Blaney, Richard J. Simpson, Catherine M. Bollard

Publikováno v: Brain, Behavior, and Immunity. 40:e32-e33

The ex vivo expansion of tumor-associated-antigen (TAA)-specific-T-cells from healthy donors for adoptive transfer to cancer patients helps prevent relapse following hematopoietic stem cell transplantation. However, the procedure is limited by the di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f44354b87fddff5695ac44111a10612b
https://doi.org/10.1016/j.bbi.2014.06.131

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