Zobrazeno 1 - 10
of 218
pro vyhledávání: '"James W, Murrough"'
Autor:
Lindsay J. Hines, Russell A. Wilke, Rachel Myers, Carol A. Mathews, Michelle Liu, Jordan F. Baye, Natasha Petry, Emily J. Cicali, Benjamin Q. Duong, Erica Elwood, Leslie Hulvershorn, Khoa Nguyen, Michelle Ramos, Azita Sadeghpour, R. Ryanne Wu, Lloyda Williamson, Kristin Wiisanen, Deepak Voora, Rajbir Singh, Kathryn V. Blake, James W. Murrough, Simona Volpi, Geoffrey S. Ginsburg, Carol R. Horowitz, Lori Orlando, Hrishikesh Chakraborty, Paul Dexter, Julie A. Johnson, Todd C. Skaar, Larisa H. Cavallari, Sara L. Van Driest, Josh F. Peterson, the IGNITE Pragmatic Trials Network
Publikováno v:
Clinical and Translational Science, Vol 17, Iss 6, Pp n/a-n/a (2024)
Abstract Specific selective serotonin reuptake inhibitors (SSRIs) metabolism is strongly influenced by two pharmacogenes, CYP2D6 and CYP2C19. However, the effectiveness of prospectively using pharmacogenetic variants to select or dose SSRIs for depre
Externí odkaz:
https://doaj.org/article/924b2d238fd2492abe1558654120a8ef
Autor:
Yael Jacob, Laurel S. Morris, Gaurav Verma, Sarah B. Rutter, Priti Balchandani, James W. Murrough
Publikováno v:
Translational Psychiatry, Vol 12, Iss 1, Pp 1-9 (2022)
Abstract The hippocampus and amygdala limbic structures are critical to the etiology of major depressive disorder (MDD). However, there are no high-resolution characterizations of the role of their subregions in the whole brain network (connectome).
Externí odkaz:
https://doaj.org/article/df1565863e3e4fb48121438c9fd2835f
Autor:
Judy Alper, Rui Feng, Gaurav Verma, Sarah Rutter, Kuang-han Huang, Long Xie, Paul Yushkevich, Yael Jacob, Stephanie Brown, Marin Kautz, Molly Schneider, Hung-Mo Lin, Lazar Fleysher, Bradley N. Delman, Patrick R. Hof, James W. Murrough, Priti Balchandani
Publikováno v:
Frontiers in Psychiatry, Vol 14 (2023)
BackgroundMajor depressive disorder (MDD) is a prevalent health problem with complex pathophysiology that is not clearly understood. Prior work has implicated the hippocampus in MDD, but how hippocampal subfields influence or are affected by MDD requ
Externí odkaz:
https://doaj.org/article/65b6c1b261c84fd182305861a1915720
Publikováno v:
PLoS ONE, Vol 18, Iss 3, p e0282727 (2023)
BackgroundThe sense of agency, or the belief in action causality, is an elusive construct that impacts day-to-day experience and decision-making. Despite its relevance in a range of neuropsychiatric disorders, it is widely under-studied and remains d
Externí odkaz:
https://doaj.org/article/4a0568f7a6c246ca82b459cd63f666f7
Autor:
Sara Costi, Audrey Evers, Manish K. Jha, Matthew Klein, Jessica R. Overbey, Ki A. Goosens, JoColl Burgess, Kelvin Alvarez, Adriana Feder, Dennis S. Charney, James W. Murrough
Publikováno v:
Neurobiology of Stress, Vol 22, Iss , Pp 100505- (2023)
Background: Stress exposure is a key risk factor for the development of major depressive disorder and posttraumatic stress disorder. Enhancing stress resilience in at-risk populations could potentially protect against stress-induced disorders. The ad
Externí odkaz:
https://doaj.org/article/2793ed9c99cb4a19aeb654f275053d32
Autor:
Flurin Cathomas, Laura Bevilacqua, Aarthi Ramakrishnan, Hope Kronman, Sara Costi, Molly Schneider, Kenny L. Chan, Long Li, Eric J. Nestler, Li Shen, Dennis S. Charney, Scott J. Russo, James W. Murrough
Publikováno v:
Translational Psychiatry, Vol 12, Iss 1, Pp 1-9 (2022)
Abstract Ketamine has rapid and sustained antidepressant effects in patients with treatment-resistant depression (TRD). However, the underlying mechanisms of action are not well understood. There is increasing evidence that TRD is associated with a p
Externí odkaz:
https://doaj.org/article/9578aab04ada4803bcc382d8a0f3d527
Autor:
Sara Costi, Laurel S. Morris, Abigail Collins, Nicolas F. Fernandez, Manishkumar Patel, Hui Xie, Seunghee Kim-Schulze, Emily R. Stern, Katherine A. Collins, Flurin Cathomas, Michael K. Parides, Alexis E. Whitton, Diego A. Pizzagalli, Scott J. Russo, James W. Murrough
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-8 (2021)
Abstract Increased levels of peripheral cytokines have been previously associated with depression in preclinical and clinical research. Although the precise nature of peripheral immune dysfunction in depression remains unclear, evidence from animal s
Externí odkaz:
https://doaj.org/article/ba742c5afe7d476aa19d67c3d88c7bb5
Autor:
Laurel S. Morris, Marishka Mehta, Christopher Ahn, Morgan Corniquel, Gaurav Verma, Bradley Delman, Patrick R. Hof, Yael Jacob, Priti Balchandani, James W. Murrough
Publikováno v:
NeuroImage, Vol 264, Iss , Pp 119704- (2022)
The ventral tegmental area (VTA) is one of the major sources of dopamine in the brain and has been associated with reward prediction, error-based reward learning, volitional drive and anhedonia. However, precise anatomical investigations of the VTA h
Externí odkaz:
https://doaj.org/article/7991ee7a706045fbadcb68da04ec8f06
Autor:
Daniel L Ranti, Andrew J Warburton, John W Rutland, Jonathan T. Dullea, Matthew Markowitz, Derek A Smith, Sophie Z Karwoska Kligler, Sarah Rutter, Mackenzie Langan, Annie Arrighi‐Allisan, Ilena George, Gaurav Verma, James W Murrough, Bradley N Delman, Priti Balchandani, Laurel S Morris
Publikováno v:
Brain and Behavior, Vol 12, Iss 7, Pp n/a-n/a (2022)
Abstract Introduction Emerging evidence in depression suggests that blood–brain barrier (BBB) breakdown and elevated inflammatory cytokines in states of persistent stress or trauma may contribute to the development of symptoms. Signal‐to‐noise
Externí odkaz:
https://doaj.org/article/63ade850f4aa4666a7d7ab219045e89e
Publikováno v:
Frontiers in Psychiatry, Vol 13 (2022)
Stress exposure is one of the greatest risk factors for psychiatric illnesses, including major depressive disorder (MDD) and posttraumatic stress disorder (PTSD). Enhancing stress resilience could potentially protect against the development of stress
Externí odkaz:
https://doaj.org/article/4adadd6440e24654bd752e50f38128bc