Different immunogenicity but similar antitumor efficacy of two DNA vaccines coding for an antigen secreted in different membrane vesicle-associated forms

Autor: Christine Sedlik, James Vigneron, Lea Torrieri-Dramard, Fabien Pitoiset, Jordan Denizeau, Caroline Chesneau, Philippe de la Rochere, Olivier Lantz, Clotilde Thery, Bertrand Bellier

Publikováno v: Journal of Extracellular Vesicles, Vol 3, Iss 0, Pp 1-13 (2014)

The induction of an active immune response to control or eliminate tumours is still an unfulfilled challenge. We focused on plasmid DNA vaccines using an innovative approach whereby the antigen is expressed in association with extracellular vesicles

Externí odkaz: https://doaj.org/article/90ad55465d674ba9b020cc69846af4f1

Low-Dose IL-2 Induces Regulatory T Cell–Mediated Control of Experimental Food Allergy

Autor: Faustine Brimaud, Fabien Pitoiset, Thomas Vazquez, David Klatzmann, Guillaume Churlaud, Bertrand Bellier, James Vigneron, Benjamin Bonnet, Béatrice Levacher

Publikováno v: Journal of Immunology
Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2016, 197 (1), pp.188-198. ⟨10.4049/jimmunol.1501271⟩
Journal of Immunology, 2016, 197 (1), pp.188-198. ⟨10.4049/jimmunol.1501271⟩

Regulatory T cells (Tregs) are pivotal for maintenance of immune self-tolerance and also regulate immune responses to exogenous Ags, including allergens. Both decreased Treg number and function have been reported in allergic patients, offering new th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c13162e51a70bc0a6f102d86dedf34f0
https://www.hal.inserm.fr/inserm-01617587

Analysis of ESCRT functions in exosome biogenesis, composition and secretion highlights the heterogeneity of extracellular vesicles

Autor: Nicolas Manel, Graça Raposo, Guillaume van Niel, Clotilde Théry, Catarina Moita, Marina Colombo, Luis F. Moita, Philippe Benaroch, James Vigneron, Joanna Kowal

Publikováno v: Journal of Cell Science

Exosomes are extracellular vesicles (EVs) secreted upon fusion of endosomal multivesicular bodies (MVBs) with the plasma membrane. The mechanisms involved in their biogenesis have not yet been fully identified although they could be used to modulate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc90b88756a9fd68e1fa24e8b9365fbd
https://doi.org/10.1242/jcs.128868