Zobrazeno 1 - 10
of 16
pro vyhledávání: '"James V. Winkler"'
Publikováno v:
The Journal of Emergency Medicine. 25:1-6
Albumin is an abundant plasma protein with multiple physiologic functions, and low serum albumin levels have been associated with increased mortality in hospitalized patients. In a retrospective matched-pair study, we investigated whether emergency d
Autor:
Richard L. Yukl, James V. Winkler, David Bar-Or, Richard Shimonkevitz, Leonard T. Rael, Gregory W. Thomas
Publikováno v:
Biochemical and Biophysical Research Communications. 290:1388-1392
Activated protein C (APC) is useful in the treatment of sepsis. Ischemia and acidosis, which often accompany sepsis, cause the release of copper from loosely bound sites. We investigated (i) whether physiological concentrations of copper inhibit APC
Publikováno v:
Biochemical and Biophysical Research Communications. 282:356-360
Both DNA and the telomeric sequence are susceptible to copper-mediated reactive oxygen species (ROS) damage, particularly damage attributed to hydroxyl radicals. In this study, ROS-induced DNA double strand breaks and telomere shortening were produce
Publikováno v:
The Journal of Emergency Medicine. 19:311-315
We initially observed a phenomenon of reduced in vitro binding of exogenous cobalt [Co(II)] to the N-terminus of human serum albumin (HSA) in emergency chest pain patients with early onset unstable angina and myocardial infarction. We then developed
Publikováno v:
Biochemical and Biophysical Research Communications. 304:755-757
Epinephrine is known to be rapidly oxidized during sepsis. Ischemia and acidosis, which often accompany sepsis, are associated with the release of weakly bound cupric ions from plasma proteins. We investigated whether copper promotes oxidation of epi
Publikováno v:
European urology. 61(4)
Background: Premature ejaculation (PE) is a widely observed male sexual dysfunction with a major impact on quality of life for many men and their sexual partners. Objective: To assess the safety of tramadol orally disintegrating tablet (ODT) (Zertane
Publikováno v:
The Journal of Emergency Medicine. 10:545-552
The effects of acute ethanol administration on acid-base balance and hemodynamic parameters were studied in a canine model. Ten mongrel dogs, anesthetized and maintained on a volume ventilator, underwent splenic artery ligation 30 minutes prior to st
Autor:
David Bar-Or, Leonard T. Rael, Raphael Bar-Or, Kent D. Heyborne, Daniel Navot, James V. Winkler
Publikováno v:
Prenatal diagnosis. 25(3)
Objectives We investigated cysteinylation of maternal plasma albumin in an observational study of intrauterine growth restriction (IUGR). High-risk pregnancies and uteroplacental insufficiency (UPI) have been associated with elevated levels of homocy
Publikováno v:
Clinica chimica acta; international journal of clinical chemistry. 362(1-2)
Cardiac troponin I (cTnI) has low sensitivity in the early hours of acute coronary syndrome (ACS). For patients with early ACS symptoms, we determined the diagnostic potential of an immunoassay for phosphorylated cTnI (PO(4)-cTnI).In a prospective st
Autor:
James V. Winkler, David Bar-Or, Richard Shimonkevitz, Richard L. Yukl, Leonard T. Rael, Gregory W. Thomas, C. Gerald Curtis
Publikováno v:
Shock (Augusta, Ga.). 20(2)
Endogenous copper can play an important role in postischemic reperfusion injury, a condition associated with endothelial cell activation and increased interleukin 8 (IL-8) production. Excessive endothelial IL-8 secreted during trauma, major surgery,