Výsledky vyhledávání - "James V. Scicolone"

Starch Products as Candidate Excipients in a Continuous Direct Compression Line

Autor: Tami Morker, Sonia M. Razavi, James V. Scicolone, Yi Tao, Charles R. Cunningham, Fernando J. Muzzio, Douglas B. Hausner, Ali R. Rajabi-Siahboomi

Publikováno v: Journal of Pharmaceutical Innovation. 17:460-471

Direct compression (DC) remains the most preferred technique to produce tablets, and its effectiveness is directly influenced by raw material attributes. Therefore, the selection of specific grades of excipients to achieve desirable powder flow and c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4d8ec236420cce18f05d485483c06ec5
https://doi.org/10.1007/s12247-020-09504-7

Zobrazit plný text záznamu

Improving Feedability of Highly Adhesive Active Pharmaceutical Ingredients by Silication

Autor: Fernando J. Muzzio, Sara Moghtadernejad, Marianthi G. Ierapetritou, M. Sebastian Escotet-Espinoza, James V. Scicolone, Ivo Van Assche, Giustino Di Pretoro, Eric Sanchez, Philippe Cappuyns

Publikováno v: Journal of Pharmaceutical Innovation. 16:279-292

Loss-in-weight feeders play a vital role in assuring blend and content uniformity as well as lot-to-lot powder traceability in continuous manufacturing. Irregular flow from the feeders propagates through the system, potentially resulting in out-of-sp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d0cda6062d48343309cd9ade4a3e6210
https://doi.org/10.1007/s12247-020-09448-y

Zobrazit plný text záznamu

Using residence time distribution in pharmaceutical solid dose manufacturing - A critical review

Autor: Andrés D. Román-Ospino, Shahrzad Talebian, Fernando J. Muzzio, Sonia M. Razavi, Ravendra Singh, Pooja Bhalode, Marianthi G. Ierapetritou, James V. Scicolone, Shashwat Gupta, Huayu Tian

Publikováno v: International journal of pharmaceutics. 610

While continuous manufacturing (CM) of pharmaceutical solid-based drug products has been shown to be advantageous for improving the product quality and process efficiency in alignment with FDA’s support of the quality-by-design paradigm (Lee, 2015;

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5008e6b9c876a8fc8021590fda3b5293
https://pubmed.ncbi.nlm.nih.gov/34748808

Zobrazit plný text záznamu

Identifying a Loss-in-Weight Feeder Design Space Based on Performance and Material Properties

Autor: Tianyi Li, Fernando J. Muzzio, James V. Scicolone, Eric Sanchez

Publikováno v: Journal of Pharmaceutical Innovation. 15:482-495

Powder properties, such as density and adhesion, can cause large variability in the flow rate of ingredients fed from feeders, which can propagate through the system. Knowing an ideal range of operation and correlating powder properties to process pe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::53e4b4463e5ebd1c23049f2bb5f57b9d
https://doi.org/10.1007/s12247-019-09394-4

Zobrazit plný text záznamu

Residence time distribution as a traceability method for lot changes in a pharmaceutical continuous manufacturing system

Autor: Fernando J. Muzzio, Adriluz Sánchez-Paternina, Rodolfo J. Romañach, Yleana C. Lugo, Pedro A. Martínez-Cartagena, Jingzhe Li, James V. Scicolone, Ravendra Singh, Andrés D. Román-Ospino

Publikováno v: International Journal of Pharmaceutics. 611:121313

Residence time distribution (RTD) models were developed to track raw material lots and investigate batch transitions in a continuous manufacturing system. Two raw materials with similar physical properties (granular metformin and lactose) were identi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5406d18ce5a589e6ed5e70c32c0e84ed
https://doi.org/10.1016/j.ijpharm.2021.121313

Zobrazit plný text záznamu

Using a material property library to find surrogate materials for pharmaceutical process development

Autor: Tamás Vigh, James V. Scicolone, Sara Moghtadernejad, Elisabeth Schäfer, Didier Klingeleers, Glinka Pereira, Yifan Wang, M. Sebastian Escotet-Espinoza, Marianthi G. Ierapetritou, Fernando J. Muzzio

Publikováno v: Powder Technology. 339:659-676

Material properties are known to have a significant impact on pharmaceutical manufacturing performance, particularly for solid product processes. Evaluating the performance of a specific material, for example an active pharmaceutical ingredient or ex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::357fda8c1b23147cd824215d08c875f6
https://doi.org/10.1016/j.powtec.2018.08.042

Zobrazit plný text záznamu

A Training on: Continuous Manufacturing (Direct Compaction) of Solid Dose Pharmaceutical Products

Autor: Sonia M. Razavi, Sarang Oka, Sara Moghtadernejad, Zhanjie Liu, Ravendra Singh, Andrés D. Román-Ospino, Tianyi Li, James V. Scicolone, Savitha S. Panikar, Fernando J. Muzzio, M. Sebastian Escotet-Espinoza, Gerardo Callegari, Douglas B. Hausner

Publikováno v: Journal of Pharmaceutical Innovation. 13:155-187

As the pharmaceutical industry increasingly adopts continuous manufacturing technology, significant attention must be paid to process analytical technology (PAT), process integration, and process control. Published information is no substitute for ha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6148472342925258700d54393f056c7a
https://doi.org/10.1007/s12247-018-9313-5

Zobrazit plný text záznamu

Method transfer of a near-infrared spectroscopic method for blend uniformity in a poorly flowing and hygroscopic blend

Autor: Andrés D. Román-Ospino, Efrain Y. Aymat, Fernando J. Muzzio, Carlos Ortega-Zúñiga, Eric Sanchez, Rodolfo J. Romañach, Yleana M. Colón-Lugo, Bárbara B. Alvarado-Hernández, James V. Scicolone

Publikováno v: Journal of pharmaceutical and biomedical analysis. 180

The challenges in transferring and executing a near-infrared (NIR) spectroscopic method for croscarmellose (disintegrant) in binary blends for a continuous manufacturing (CM) process are presented. This work demonstrates the development of a NIR cali

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caf6eaeb6a22c37b7553afd4e0d67c83
https://pubmed.ncbi.nlm.nih.gov/31881395

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání