Zobrazeno 1 - 10
of 105
pro vyhledávání: '"James V. Bruckner"'
Autor:
Catherine A. White, Tanzir Mortuza, Srinivasa Muralidhara, Brian S. Cummings, James V. Bruckner, Pankaj K. Sethi
Publikováno v:
Drug Metabolism and Disposition. 47:941-948
The majority of residents of the United States, Canada, and Europe are exposed to pyrethroids, the most commonly used class of insecticides. Surprisingly little is known about key aspects of their pharmacokinetics, including their mode of transport i
Autor:
James V. Bruckner, Gaylen L. Edwards, Tanzir Mortuza, Catherine A. White, Vandan Patel, Brian S. Cummings
Publikováno v:
Drug Metabolism and Disposition. 47:234-237
Permethrin (PER), a type I pyrethroid, is the most widely used insecticide in domestic settings in the United States. The overall objective of this study was to assess the efficiency of the blood-brain barrier (BBB) as an obstacle to the 14C-cis-perm
Autor:
Brian S. Cummings, Catherine A. White, Carey Hines, James V. Bruckner, Tanzir Mortuza, Srinivasa Muralidhara
Publikováno v:
Toxicology and Applied Pharmacology. 360:185-192
Trichloroethylene (TCE) and 1,1,1-trichloroethane (TRI) are frequent contaminants of drinking water and of groundwater at hazardous waste sites. There is relatively little information on the target organ deposition of TRI, despite its ingestion and c
Autor:
Brian S. Cummings, James V. Bruckner, Tanzir Mortuza, Catherine A. White, Darren R. Gullick, Srinivasa Muralidhara, Chen Chen
Publikováno v:
Toxicological Sciences. 162:327-336
There is increasing concern that infants and children may be at increased risk of neurological effects of pyrethroids, the most widely used class of insecticide. The objectives of this investigation were to (1) characterize the dose-dependent toxicok
Autor:
James V. Bruckner, Srinivasa Muralidhara, Catherine A. White, Brian S. Cummings, Jewell T. Wilson, Brooks T. McPhail
Publikováno v:
Chemico-Biological Interactions. 256:167-177
Concern about potential susceptibilities of infants and children to chemicals has led to the consideration of immature rodents as potential test surrogates. Maturation of some hepatic microsomal cytochrome P450s (CYPs), that participate in metabolic
Autor:
Srinivasa Muralidhara, James V. Bruckner, Jing Pang, Anshika Sharma, Catherine A. White, Brian S. Cummings, Jason Zastre, Manoj Amaraneni
Publikováno v:
Toxicology Letters. :21-28
Previous pharmacokinetic studies of deltamethrin (DLM) have revealed that brain levels of this highly lipophilic pyrethroid insecticide are only 15-20% of plasma levels. Experiments were performed to assess determinants limiting CNS access including
Autor:
Tanzir B, Mortuza, Gaylen L, Edwards, Catherine A, White, Vandan, Patel, Brian S, Cummings, James V, Bruckner
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 47(3)
Permethrin (PER), a type I pyrethroid, is the most widely used insecticide in domestic settings in the United States. The overall objective of this study was to assess the efficiency of the blood-brain barrier (BBB) as an obstacle to the
Autor:
Michael G. Bartlett, Shirin Hooshfar, Michael R. Linzey, James V. Bruckner, Catherine A. White, Clinton A. Rogers, Tanzir Mortuza, Darren R. Gullick
Publikováno v:
Rapid communications in mass spectrometry : RCM. 31(19)
RATIONALE Transfluthrin is a relatively non-toxic rapid-acting synthetic pyrethroid insecticide. It is widely used in household and hygiene products. A sensitive and accurate bioanalytical method is required for quantification of its concentration in
Autor:
James V. Bruckner, Srinivasa Muralidhara, Brian S. Cummings, Jason Zastre, Tanzir B. Mortuza, Charles V. Vorhees, Catherine A. White, Manoj Amaraneni, Jing Pang
Publikováno v:
Neurotoxicology. 62
Pyrethroids, including permethrin and deltamethrin (DLM), are very widely used of insecticides. It was hypothesized that lower plasma binding and increased blood-brain barrier (BBB) penetration of DLM in immature rats contribute to the higher brain c
Autor:
James V. Bruckner, Brian S. Cummings, Tanzir Mortuza, Darren R. Gullick, Shirin Hooshfar, Srinivasa Muralidhara, Manoj Amaraneni, Catherine A. White, Jing Pang
Publikováno v:
Journal of pharmaceutical sciences. 106(8)
Permethrin, the most widely used household insecticide in the United States, is marketed as a mixture of its cis (CIS) and trans (TRANS) isomers. The major objective of this investigation is to develop and utilize a reliable approach to determine in