Zobrazeno 1 - 6
of 6
pro vyhledávání: '"James V. Belcastro"'
Autor:
James V. Belcastro, Colleen A. McNaney, Robert Langish, Dieter M. Drexler, Adrienne A. Tymiak, Kenneth S. Santone, Serhiy Hnatyshyn, Kurt J. Edinger, Petia Shipkova, Mark Sanders, Tatyana Zvyaga, Kenneth E.J. Dickinson, Jonathan L. Josephs
Publikováno v:
ASSAY and Drug Development Technologies. 5:247-264
An automated high throughput process, termed the MetFast assay, is described to assess in vitro the general microsomal cytochrome P450 beta-nicotinamide adenine dinucleotide phosphate-mediated first-pass metabolic stability of potential drug candidat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7689bed173b88b9f308efae344982c5
https://doi.org/10.1089/adt.2006.038
https://doi.org/10.1089/adt.2006.038
Publikováno v:
Journal of biomolecular screening. 20(5)
High-performance liquid chromatography (HPLC) biogram methodology is a powerful pharmaceutical screening hit confirmation strategy that couples analytical HPLC data with functional bioassay data. It is used primarily for screening hit chemical valida
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::811234c638846e212ffd38f4aa3e5399
https://pubmed.ncbi.nlm.nih.gov/25681433
https://pubmed.ncbi.nlm.nih.gov/25681433
Autor:
Moneesh Chatterjee, Martyn Banks, James V. Belcastro, John Watson, John E. Leet, John J. Herbst, Michael J. Ford, Dieter M. Drexler, Emily B. Greenough
Publikováno v:
Journal of biomolecular screening. 14(5)
Disposable plastic labware is ubiquitous in contemporary pharmaceutical research laboratories. Plastic labware is routinely used for chemical compound storage and during automated liquid-handling processes that support assay development, high-through
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::331db152fe18c37402ea972ff5d728e6
https://pubmed.ncbi.nlm.nih.gov/19470712
https://pubmed.ncbi.nlm.nih.gov/19470712
Autor:
Serhiy Hnatyshyn, Dieter M. Drexler, Jay O. Knipe, Colleen A. McNaney, James V. Belcastro, Mark Sanders, Tatyana Zvyaga
Publikováno v:
Assay and drug development technologies. 6(1)
An automated process is described for the detailed assessment of the in vitro metabolic stability properties of drug candidates in support of pharmaceutical property profiling. Compounds are incubated with liver microsomes using a robotic liquid hand
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5e9919e121b0dd1be66f31dfe89e85f
https://pubmed.ncbi.nlm.nih.gov/18336089
https://pubmed.ncbi.nlm.nih.gov/18336089
Autor:
Colleen A. McNaney, Dieter M. Drexler, Serhiy Y. Hnatyshyn, Tatyana A. Zvyaga, Jay O. Knipe, James V. Belcastro, Mark Sanders
Publikováno v:
Assay & Drug Development Technologies; Feb2008, Vol. 6 Issue 1, p121-129, 9p
Autor:
Dieter M. Drexler, James V. Belcastro, Kenneth E. Dickinson, Kurt J. Edinger, Serhiy Y. Hnatyshyn, Jonathan L. Josephs, Robert A. Langish, Colleen A. McNaney, Kenneth S. Santone, Petia A. Shipkova, Adrienne A. Tymiak, Tatyana A. Zvyaga, Mark Sanders
Publikováno v:
Assay & Drug Development Technologies; Apr2007, Vol. 5 Issue 2, p247-264, 1p