Zobrazeno 1 - 10
of 12
pro vyhledávání: '"James Upward"'
A fixed-dose, dose–response study of ropinirole prolonged release in early stage Parkinson's disease
Publikováno v:
Neurodegenerative Disease Management. 7:49-59
Aim: This Phase IV, double-blind, randomized, parallel-group study characterized the dose–response and tolerability of fixed doses of ropinirole prolonged release (PR). Patients & methods: Subjects with early Parkinson's disease (PD) received place
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6bddb08fa34e732c2236166f7c805b8
https://doi.org/10.2217/nmt-2016-0039
https://doi.org/10.2217/nmt-2016-0039
Publikováno v:
Clinical Therapeutics. 37:349-357
Purpose Coadministration of morphine with oral gabapentin has been shown to increase plasma gabapentin concentrations. This study evaluated whether there was any interaction between gabapentin enacarbil (GEn), which is a prodrug of gabapentin, and mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abadb02293553a4f153a6d99759eba70
https://doi.org/10.1016/j.clinthera.2014.10.015
https://doi.org/10.1016/j.clinthera.2014.10.015
Autor:
Maria Davy, Theresa A. Zesiewicz, James Upward, Stephen Chriscoe, Susan VanMeter, Theresa Jimenez
Publikováno v:
Neurodegenerative disease management. 7(1)
Aim: This Phase IV, double-blind, randomized, parallel-group study characterized the dose-response and tolerability of fixed doses of ropinirole prolonged release (PR) in subjects with advanced Parkinson's disease. Patients & methods: Subjects receiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0141bddd2089eb34c1fc7a0f064c578b
https://pubmed.ncbi.nlm.nih.gov/28120630
https://pubmed.ncbi.nlm.nih.gov/28120630
Publikováno v:
Clinical Pharmacology in Drug Development. 1:85-92
OBJECTIVE The objective was to compare the pharmacokinetics of sumatriptan and naproxen in adolescent migraineurs and healthy adults after administration of sumatriptan/naproxen sodium combination tablets. DESIGN The design was an open-label, randomi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::feada382646f38e049ea0e931b3fa21e
https://doi.org/10.1177/2160763x12447302
https://doi.org/10.1177/2160763x12447302
Autor:
Andreas Port, John Kelly, Zussman Barry D, Peter Wyld, Robert D. Murdoch, David J. Clark, Dawn M. Webber, James Upward, Lisa J. Benincosa, Hermann Fuder, Hugh Cowley
Publikováno v:
The Journal of Clinical Pharmacology. 41:950-958
The oral pharmacokinetics of cilomilast (Ariflo®) were investigated in five separate studies in healthy volunteers. Cilomilast was rapidly absorbed, and pharmacokinetics were dose proportional after single and repeat dosing. The elimination half-lif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cbcba76d7feb22a88a44b76459cbf552
https://doi.org/10.1177/009127000104100904
https://doi.org/10.1177/009127000104100904
Publikováno v:
Clinical therapeutics. 35(12)
Background Gabapentin enacarbil (GEn) is a prodrug of gabapentin and is approved in the United States in adults for the management of postherpetic neuralgia and in the United States and Japan for the treatment of moderate-to-severe primary restless l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dcab612f53cf8ef1500d065f24fc2db
https://pubmed.ncbi.nlm.nih.gov/24290737
https://pubmed.ncbi.nlm.nih.gov/24290737
Autor:
Kate Howland, Dion R. Brocks, Charles McHugh, Christopher Compton, Maria Davy, Michael J. Dennis, James Upward
Publikováno v:
British Journal of Clinical Pharmacology. 44:289-291
Aims To study the magnitude of differences in the pharmacokinetics of pranlukast, after morning and evening administration. Methods Pranlukast (300 mg) was administered to 12 healthy male volunteers on two separate occasions, either in the morning or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14e518ca17328ada8058ab1dabf88b46
https://doi.org/10.1046/j.1365-2125.1997.00650.x
https://doi.org/10.1046/j.1365-2125.1997.00650.x
Publikováno v:
European Journal of Cancer and Clinical Oncology. 27:1081-1083
In an open ascending-dose study, granisetron, a specific 5-HT3 receptor antagonist, was administered to 24 paediatric patients (17 male, 7 female, mean age 6.2, range 3-15 years) who were receiving moderately or highly emetogenic chemotherapy for mal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::970bbdaa5d02fcb553f94f655ddeb7a0
https://doi.org/10.1016/0277-5379(91)90296-p
https://doi.org/10.1016/0277-5379(91)90296-p
Autor:
F. Akhras, J. Keates, John D. Harry, James Upward, Graham Jackson, Christopher Bass, Derek Lowe
Publikováno v:
Journal of Psychosomatic Research. 31:521-529
A double-blind prospective randomized trial of atenolol (100 mg once daily) was carried out on 88 patients (78 men) awaiting coronary artery bypass graft surgery. Standardized ratings of both psychiatric morbidity and functional capacity were made be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09a0b6c441a5115cf386c730f7f72996
https://doi.org/10.1016/0022-3999(87)90010-9
https://doi.org/10.1016/0022-3999(87)90010-9
Publikováno v:
The American Journal of Cardiology. 55:1589-1595
Bepridil, a fast and slow channel blocking drug, was administered intravenously over 5 minutes in a dose of 3 mg/kg body weight to 19 patients. Ten patients received intravenous bepridil during electrophysiologic study, performed for the investigatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed655f414bd959a6ab675c9371914bc7
https://doi.org/10.1016/0002-9149(85)90978-6
https://doi.org/10.1016/0002-9149(85)90978-6