Výsledky vyhledávání - "James Uniacke"

Akademický článek

Pharmacological inhibition of neuropeptide Y receptors Y1 and Y5 reduces hypoxic breast cancer migration, proliferation, and signaling

Autor: Sydney A. Pascetta, Sarah M. Kirsh, Makenna Cameron, James Uniacke

Publikováno v: BMC Cancer, Vol 23, Iss 1, Pp 1-15 (2023)

Abstract Background Neuropeptide Y (NPY) is an abundant neurohormone in human breast carcinomas that acts on a class of G-protein coupled receptors, of which NPY1R and NPY5R are the most highly expressed. This abundance is exploited for cancer imagin

Externí odkaz: https://doaj.org/article/91185494089d4bd8a819c512e903ef36

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Akademický článek

Translational control of breast cancer plasticity

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)

Protein synthesis suppression protects breast cancer cells from clinically relevant stresses like hypoxia. Here, the authors show that unique mRNA isoforms that govern stem cell-like phenotypes escape translational repression to drive tumor progressi

Externí odkaz: https://doaj.org/article/312a98522c974e78ae7065a78eaa0f90

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Akademický článek

Systemic Reprogramming of Translation Efficiencies on Oxygen Stimulus

Autor: J.J. David Ho, Miling Wang, Timothy E. Audas, Deukwoo Kwon, Steven K. Carlsson, Sara Timpano, Sonia L. Evagelou, Shaun Brothers, Mark L. Gonzalgo, Jonathan R. Krieger, Steven Chen, James Uniacke, Stephen Lee

Publikováno v: Cell Reports, Vol 14, Iss 6, Pp 1293-1300 (2016)

Protein concentrations evolve under greater evolutionary constraint than mRNA levels. Translation efficiency of mRNA represents the chief determinant of basal protein concentrations. This raises a fundamental question of how mRNA and protein levels a

Externí odkaz: https://doaj.org/article/bedf0004e3654887b81b21831af96206

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Akademický článek

Pyrenoid functions revealed by proteomics in Chlamydomonas reinhardtii.

Autor: Yu Zhan, Christophe H Marchand, Alexandre Maes, Adeline Mauries, Yi Sun, James S Dhaliwal, James Uniacke, Simon Arragain, Heng Jiang, Nicholas D Gold, Vincent J J Martin, Stéphane D Lemaire, William Zerges

Publikováno v: PLoS ONE, Vol 13, Iss 2, p e0185039 (2018)

Organelles are intracellular compartments which are themselves compartmentalized. Biogenic and metabolic processes are localized to specialized domains or microcompartments to enhance their efficiency and suppress deleterious side reactions. An examp

Externí odkaz: https://doaj.org/article/6769398fc55a492fbbf2a4c02a9a5cc3

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