Zobrazeno 1 - 5
of 5
pro vyhledávání: '"James Torpy"'
Autor:
Emily Jane Meyer, Marni Anne Nenke, Michael Laurence Davies, Marianne Chapman, Wayne Rankin, R Louise Rushworth, David James Torpy
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 107:1636-1646
Context Hydrocortisone administration in septic shock remains controversial. Corticosteroid-binding globulin (CBG) transports cortisol to inflammatory sites and is depleted in septic shock. Objective To determine whether severely deficient serum CBG
Autor:
Smadar Kahana-Edwin, James Torpy, Lucy E. Cain, Anna Mullins, Geoffrey McCowage, Sarah E. Woodfield, Sanjeev A. Vasudevan, Dan P.T. Shea, Andre E Minoche, Sarah Kummerfeld, Leonard D. Goldstein, Jonathan Karpelowsky
Driver mutations in CTNNB1 are a hallmark of hepatoblastoma and offer a common biomarker for a liquid biopsy approach based on the presence of CTNNB1 circulating tumor DNA (ctDNA). We developed and investigated the utility of a quantitative universal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc6fead0d64f60d29ff564abe6763047
https://doi.org/10.1101/2022.09.20.22279947
https://doi.org/10.1101/2022.09.20.22279947
Autor:
David James Torpy
The hypothalamic-pituitary-adrenal axis has as its primary function, the production and regulation of cortisol secretion. The major regulatory influence is stress, often defined as a threat to homeostasis. Inhibition of cortisol secretion is provided
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1dccb15f63833d94afb0e6f02f60cb8f
https://doi.org/10.14264/870be96
https://doi.org/10.14264/870be96
Autor:
Danielle T. Avery, Rita Beier, Annaliesse Blincoe, Rubén Martínez-Barricarte, David A. Fulcher, Jamila El Baghdadi, Aydan Ikinciogullari, Sara Sebnem Kilic, Yoshiyuki Minegishi, Geetha Rao, Capucine Picard, Melanie Wong, Kathryn Payne, Michael Stormon, Polina Stepensky, Gulbu Uzel, Paul Gray, Stephen Adelstein, Martyn A. French, Masao Kobayashi, Matthew C. Cook, Jean-Laurent Casanova, Klaus Warnatz, Stuart G. Tangye, Bodo Grimbacher, Aziz Bousfiha, Stéphanie Boisson-Dupuis, Natalie Wong, Patrick O’Young, Tri Giang Phan, Akira Nguyen, James Torpy, Michael Elliott, Cindy S. Ma, John B. Ziegler, Steven M. Holland, Peter Hsu, Elissa K. Deenick, Satoshi Okada, Jacinta Bustamante, Sophie Hambleton, Dianne E. Campbell, Anne Puel, Peter D. Arkwright, Kaan Boztug, Nic Robertson
Publikováno v:
The Journal of Experimental Medicine
Ma, C S, Wong, N, Rao, G, Nguyen, A, Avery, D T, Payne, K, Torpy, J, O'Young, P, Deenick, E, Bustamante, J, Puel, A, Okada, S, Kobayashi, M, Martinez-Barricarte, R, Elliott, M, Kilic, S S, Baghdadi, J E, Minegishi, Y, Bousfiha, A, Robertson, N, Hambleton, S, Arkwright, P, French, M, Blincoe, A K, Hsu, P, Campbell, D E, Stormon, M O, Wong, M, Adelstein, S, Fulcher, D A, Cook, M C, Stepensky, P, Boztug, K, Beier, R, Ikincioğullari, A, Ziegler, J B, Gray, P, Picard, C, Boisson-Dupuis, S, Phan, T G, Grimbacher, B, Warnatz, K, Holland, S M, Uzel, G, Casanova, J L & Tangye, S G 2016, ' Unique and shared signaling pathways cooperate to regulate the differentiation of human CD4 + T cells into distinct effector subsets ', Journal of Experimental Medicine, vol. 213, no. 8, pp. 1589-1608 . https://doi.org/10.1084/jem.20151467
Ma, C S, Wong, N, Rao, G, Nguyen, A, Avery, D T, Payne, K, Torpy, J, O'Young, P, Deenick, E, Bustamante, J, Puel, A, Okada, S, Kobayashi, M, Martinez-Barricarte, R, Elliott, M, Kilic, S S, Baghdadi, J E, Minegishi, Y, Bousfiha, A, Robertson, N, Hambleton, S, Arkwright, P, French, M, Blincoe, A K, Hsu, P, Campbell, D E, Stormon, M O, Wong, M, Adelstein, S, Fulcher, D A, Cook, M C, Stepensky, P, Boztug, K, Beier, R, Ikincioğullari, A, Ziegler, J B, Gray, P, Picard, C, Boisson-Dupuis, S, Phan, T G, Grimbacher, B, Warnatz, K, Holland, S M, Uzel, G, Casanova, J L & Tangye, S G 2016, ' Unique and shared signaling pathways cooperate to regulate the differentiation of human CD4 + T cells into distinct effector subsets ', Journal of Experimental Medicine, vol. 213, no. 8, pp. 1589-1608 . https://doi.org/10.1084/jem.20151467
Tangye and collaborators use a series of mutants to elucidate the pathways required to generate distinct subsets of human effector CD4+ T cells.
Naive CD4+ T cells differentiate into specific effector subsets—Th1, Th2, Th17, and T follicular h
Naive CD4+ T cells differentiate into specific effector subsets—Th1, Th2, Th17, and T follicular h
Autor:
Geetha Rao, Dianne E. Campbell, Anne Puel, Masao Kobayashi, Matthew C. Cook, Sara Sebnem Kilic, Danielle T. Avery, Rita Beier, Polina Stepensky, Stéphanie Boisson-Dupuis, Yoshiyuki Minegishi, Stuart G. Tangye, Davood Mansouri, Michael Stormon, Satoshi Okada, Shigeaki Nonoyama, Thomas Hambridge, Jean-Laurent Casanova, Stephen Adelstein, Joanne Smart, David A. Fulcher, Klaus Warnatz, Kaan Boztug, Kathryn Payne, Tony Roscioli, Annaliesse Blincoe, Steven M. Holland, Aydan Kansu, Gulbu Uzel, Jamila El Baghdadi, Bodo Grimbacher, Aziz Bousfiha, James Torpy, Seyed Alireza Mahdaviani, Capucine Picard, Simon J. Pelham, Aydan Ikinciogullari, Natalie Wong, Paul Gray, Martyn A. French, Tri Giang Phan, Melanie Wong, Cindy S. Ma, Ulrich Baumann, Peter Hsu, Elissa K. Deenick, Jacinta Bustamante, Peter D. Arkwright, John B. Ziegler, Jennifer Stoddard
Publikováno v:
The Journal of allergy and clinical immunology. 136(4)
Background Follicular helper T (T FH ) cells underpin T cell–dependent humoral immunity and the success of most vaccines. T FH cells also contribute to human immune disorders, such as autoimmunity, immunodeficiency, and malignancy. Understanding th