Using brain cell-type-specific protein interactomes to interpret neurodevelopmental genetic signals in schizophrenia

Autor: Yu-Han H. Hsu, Greta Pintacuda, Ruize Liu, Eugeniu Nacu, April Kim, Kalliopi Tsafou, Natalie Petrossian, William Crotty, Jung Min Suh, Jackson Riseman, Jacqueline M. Martin, Julia C. Biagini, Daya Mena, Joshua K.T. Ching, Edyta Malolepsza, Taibo Li, Tarjinder Singh, Tian Ge, Shawn B. Egri, Benjamin Tanenbaum, Caroline R. Stanclift, Annie M. Apffel, Steven A. Carr, Monica Schenone, Jake Jaffe, Nadine Fornelos, Hailiang Huang, Kevin C. Eggan, Kasper Lage, Stephan Ripke, Benjamin M. Neale, Aiden Corvin, James T.R. Walters, Kai-How Farh, Peter A. Holmans, Phil Lee, Brendan Bulik-Sullivan, David A. Collier, Tune H. Pers, Ingrid Agartz, Esben Agerbo, Margot Albus, Madeline Alexander, Farooq Amin, Silviu A. Bacanu, Martin Begemann, Richard A. Belliveau, Jr., Judit Bene, Sarah E. Bergen, Elizabeth Bevilacqua, Tim B. Bigdeli, Donald W. Black, Richard Bruggeman, Nancy G. Buccola, Randy L. Buckner, William Byerley, Wiepke Cahn, Guiqing Cai, Dominique Campion, Rita M. Cantor, Vaughan J. Carr, Noa Carrera, Stanley V. Catts, Kimberley D. Chambert, Raymond C.K. Chan, Ronald Y.L. Chan, Eric Y.H. Chen, Wei Cheng, Eric FC. Cheung, Siow Ann Chong, C. Robert Cloninger, David Cohen, Nadine Cohen, Paul Cormican, Nick Craddock, James J. Crowley, David Curtis, Michael Davidson, Kenneth L. Davis, Franziska Degenhardt, Jurgen Del Favero, Ditte Demontis, Dimitris Dikeos, Timothy Dinan, Srdjan Djurovic, Gary Donohoe, Elodie Drapeau, Jubao Duan, Frank Dudbridge, Naser Durmishi, Peter Eichhammer, Johan Eriksson, Valentina Escott-Price, Laurent Essioux, Ayman H. Fanous, Martilias S. Farrell, Josef Frank, Lude Franke, Robert Freedman, Nelson B. Freimer, Marion Friedl, Joseph I. Friedman, Menachem Fromer, Giulio Genovese, Lyudmila Georgieva, Ina Giegling, Paola Giusti-Rodríguez, Stephanie Godard, Jacqueline I. Goldstein, Vera Golimbet, Srihari Gopal, Jacob Gratten, Lieuwe de Haan, Christian Hammer, Marian L. Hamshere, Mark Hansen, Thomas Hansen, Vahram Haroutunian, Annette M. Hartmann, Frans A. Henskens, Stefan Herms, Joel N. Hirschhorn, Per Hoffmann, Andrea Hofman, Mads V. Hollegaard, David M. Hougaard, Masashi Ikeda, Inge Joa, Antonio Julià, René S. Kahn, Luba Kalaydjieva, Sena Karachanak-Yankova, Juha Karjalainen, David Kavanagh, Matthew C. Keller, James L. Kennedy, Andrey Khrunin, Yunjung Kim, Janis Klovins, James A. Knowles, Bettina Konte, Vaidutis Kucinskas, Zita Ausrele Kucinskiene, Hana Kuzelova-Ptackova, Anna K. Kähler, Claudine Laurent, Jimmy Lee, S. Hong Lee, Sophie E. Legge, Bernard Lerer, Miaoxin Li, Tao Li, Kung-Yee Liang, Jeffrey Lieberman, Svetlana Limborska, Carmel M. Loughland, Jan Lubinski, Jouko Lönnqvist, Milan Macek, Patrik K.E. Magnusson, Brion S. Maher, Wolfgang Maier, Jacques Mallet, Sara Marsal, Manuel Mattheisen, Morten Mattingsdal, Robert W. McCarley, Colm McDonald, Andrew M. McIntosh, Sandra Meier, Carin J. Meijer, Bela Melegh, Ingrid Melle, Raquelle I. Mesholam-Gately, Andres Metspalu, Patricia T. Michie, Lili Milani, Vihra Milanova, Younes Mokrab, Derek W. Morris, Ole Mors, Kieran C. Murphy, Robin M. Murray, Inez Myin-Germeys, Bertram Müller-Myhsok, Mari Nelis, Igor Nenadic, Deborah A. Nertney, Gerald Nestadt, Kristin K. Nicodemus, Liene Nikitina-Zake, Laura Nisenbaum, Annelie Nordin, Eadbhard O'Callaghan, Colm O'Dushlaine, F. Anthony O'Neill, Sang-Yun Oh, Ann Olincy, Line Olsen, Jim Van Os, Christos Pantelis, George N. Papadimitriou, Sergi Papiol, Elena Parkhomenko, Michele T. Pato, Tiina Paunio, Milica Pejovic-Milovancevic, Diana O. Perkins, Olli Pietiläinen, Jonathan Pimm, Andrew J. Pocklington, John Powell, Alkes Price, Ann E. Pulver, Shaun M. Purcell, Digby Quested, Henrik B. Rasmussen, Abraham Reichenberg, Mark A. Reimers, Alexander L. Richards, Joshua L. Roffman, Panos Roussos, Douglas M. Ruderfer, Veikko Salomaa, Alan R. Sanders, Ulrich Schall, Christian R. Schubert, Thomas G. Schulze, Sibylle G. Schwab, Edward M. Scolnick, Rodney J. Scott, Larry J. Seidman, Jianxin Shi, Engilbert Sigurdsson, Teimuraz Silagadze, Jeremy M. Silverman, Kang Sim, Petr Slominsky, Jordan W. Smoller, Hon-Cheong So, Chris C.A. Spencer, Eli A. Stahl, Hreinn Stefansson, Stacy Steinberg, Elisabeth Stogmann, Richard E. Straub, Eric Strengman, Jana Strohmaier, T Scott Stroup, Mythily Subramaniam, Jaana Suvisaari, Dragan M. Svrakic, Jin P. Szatkiewicz, Erik Söderman, Srinivas Thirumalai, Draga Toncheva, Sarah Tosato, Juha Veijola, John Waddington, Dermot Walsh, Dai Wang, Qiang Wang, Bradley T. Webb, Mark Weiser, Dieter B. Wildenauer, Nigel M. Williams, Stephanie Williams, Stephanie H. Witt, Aaron R. Wolen, Emily H.M. Wong, Brandon K. Wormley, Hualin Simon Xi, Clement C. Zai, Xuebin Zheng, Fritz Zimprich, Naomi R. Wray, Kari Stefansson, Peter M. Visscher, Rolf Adolfsson, Ole A. Andreassen, Douglas H.R. Blackwood, Elvira Bramon, Joseph D. Buxbaum, Anders D. Børglum, Sven Cichon, Ariel Darvasi, Enrico Domenici, Hannelore Ehrenreich, Tõnu Esko, Pablo V. Gejman, Michael Gill, Hugh Gurling, Christina M. Hultman, Nakao Iwata, Assen V. Jablensky, Erik G. Jönsson, Kenneth S. Kendler, George Kirov, Jo Knight, Todd Lencz, Douglas F. Levinson, Qingqin S. Li, Jianjun Liu, Anil K. Malhotra, Steven A. McCarroll, Andrew McQuillin, Jennifer L. Moran, Preben B. Mortensen, Bryan J. Mowry, Markus M. Nöthen, Roel A. Ophoff, Michael J. Owen, Aarno Palotie, Carlos N. Pato, Tracey L. Petryshen, Danielle Posthuma, Marcella Rietschel, Brien P. Riley, Dan Rujescu, Pak C. Sham, Pamela Sklar, David St Clair, Daniel R. Weinberger, Jens R. Wendland, Thomas Werge, Mark J. Daly, Patrick F. Sullivan, Michael C. O'Donovan, Shengying Qin, Akira Sawa, Rene Kahn, Kyung Sue Hong, Wenzhao Shi, Ming Tsuang, Masanari Itokawa, Gang Feng, Stephen J. Glatt, Xiancang Ma, Jinsong Tang, Yunfeng Ruan, Feng Zhu, Yasue Horiuchi, Byung Dae Lee, Eun-Jeong Joo, Woojae Myung, Kyooseob Ha, Hong-Hee Won, Ji Hyung Baek, Young Chul Chung, Sung-Wan Kim, Agung Kusumawardhani, Wei J. Chen, Hai-Gwo Hwu, Akitoyo Hishimoto, Ikuo Otsuka, Ichiro Sora, Tomoko Toyota, Takeo Yoshikawa, Hiroshi Kunugi, Kotaro Hattori, Sayuri Ishiwata, Shusuke Numata, Tetsuro Ohmori, Makoto Arai, Yuji Ozeki, Kumiko Fujii, Se Joo Kim, Heon-Jeong Lee, Yong Min Ahn, Se Hyun Kim, Kazufumi Akiyama, Kazutaka Shimoda, Makoto Kinoshita

Publikováno v: iScience, Vol 26, Iss 5, Pp 106701- (2023)

Summary: Genetics have nominated many schizophrenia risk genes and identified convergent signals between schizophrenia and neurodevelopmental disorders. However, functional interpretation of the nominated genes in the relevant brain cell types is oft

Externí odkaz: https://doaj.org/article/49cc77d8d4ee4572b1f6ef76532d303e

Motor-related oscillatory activity in schizophrenia according to phase of illness and clinical symptom severity

Autor: Lauren E. Gascoyne, Matthew J. Brookes, Mohanbabu Rathnaiah, Mohammad Zia Ul Haq Katshu, Loes Koelewijn, Gemma Williams, Jyothika Kumar, James T.R. Walters, Zelekha A. Seedat, Lena Palaniyappan, J.F. William Deakin, Krish D. Singh, Peter F. Liddle, Peter G. Morris

Publikováno v: NeuroImage: Clinical, Vol 29, Iss , Pp 102524- (2021)

Magnetoencephalography (MEG) measures magnetic fields generated by synchronised neural current flow and provides direct inference on brain electrophysiology and connectivity, with high spatial and temporal resolution. The movement-related beta decrea

Externí odkaz: https://doaj.org/article/c2366ba9c9934b14932231342cbbc0a0

Factors associated with anxiety disorder comorbidity

Autor: Molly R. Davies, Kiran Glen, Jessica Mundy, Abigail R. ter Kuile, Brett N. Adey, Chérie Armour, Elham Assary, Jonathan R.I. Coleman, Kimberley A. Goldsmith, Colette R. Hirsch, Matthew Hotopf, Christopher Hübel, Ian R. Jones, Gursharan Kalsi, Georgina Krebs, Andrew M. McIntosh, Geneviève Morneau-Vaillancourt, Alicia J. Peel, Kirstin L. Purves, Sang Hyuck Lee, Megan Skelton, Daniel J. Smith, David Veale, James T.R. Walters, Katherine S. Young, Johan Zvrskovec, Gerome Breen, Thalia C. Eley

Publikováno v: Davies, M R, Glen, K, Mundy, J, Adey, B, Armour, C, Assary, E, Coleman, J, Goldsmith, K, Hirsch, C, Hotopf, M, Hübel, C, Jones, I, Kalsi, G, Krebs, G, McIntosh, A M, Morneau-Vaillancourt, G, Peel, A, Purves, K, Lee, S, Skelton, M, Smith, D J, Veale, D, Walters, J, Young, K, Källberg Zvrskovec, J, Breen, G & Grant, T E 2023, ' Factors associated with anxiety disorder comorbidity ', Journal of Affective Disorders, vol. 323, pp. 280-291 . https://doi.org/10.1016/j.jad.2022.11.051
Davies, M R, Glen, K, Mundy, J, Kuile, A R T, Adey, B N, Armour, C, Assary, E, Coleman, J R I, Goldsmith, K A, Hirsch, C R, Hotopf, M, Hübel, C, Jones, I R, Kalsi, G, Krebs, G, McIntosh, A M, Morneau-Vaillancourt, G, Peel, A J, Purves, K L, Lee, S H, Skelton, M, Smith, D J, Veale, D, Walters, J T R, Young, K S, Zvrskovec, J, Breen, G & Eley, T C 2023, ' Factors associated with anxiety disorder comorbidity ', Journal of Affective Disorders, vol. 323, pp. 280-291 . https://doi.org/10.1016/j.jad.2022.11.051
Davies, M R, Glen, K, Mundy, J, Ter Kuile, A R, Adey, B N, Armour, C, Assary, E, Coleman, J R I, Goldsmith, K A, Hirsch, C R, Hotopf, M, Hübel, C, Jones, I R, Kalsi, G, Krebs, G, McIntosh, A M, Morneau-Vaillancourt, G, Peel, A J, Purves, K L, Lee, S H, Skelton, M, Smith, D J, Veale, D, Walters, J T R, Young, K S, Zvrskovec, J, Breen, G & Eley, T C 2023, ' Factors associated with anxiety disorder comorbidity ', Journal of Affective Disorders, vol. 323, pp. 280-291 . https://doi.org/10.1016/j.jad.2022.11.051
Davies, M R, Glen, K, Mundy, J, Ter Kuile, A R, Adey, B N, Armour, C, Assary, E, Coleman, J R I, Goldsmith, K A, Hirsch, C R, Hotopf, M, Hübel, C, Jones, I R, Kalsi, G, Krebs, G, McIntosh, A M, Morneau-Vaillancourt, G, Peel, A J, Purves, K L, Lee, S H, Skelton, M, Smith, D J, Veale, D, Walters, J T R, Young, K S, Zvrskovec, J, Breen, G & Eley, T C 2022, ' Factors associated with anxiety disorder comorbidity ', Journal of Affective Disorders (JAD) . https://doi.org/10.1016/j.jad.2022.11.051

BackgroundAnxiety and depressive disorders often co-occur and the order of their emergence may be associated with different clinical outcomes. However, minimal research has been conducted on anxiety-anxiety comorbidity. This study examined factors as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8507ef0fe5b84d714c262376017724af
https://kclpure.kcl.ac.uk/en/publications/6be14141-2856-46f3-8145-6b176d798a3b

Pharmacokinetics and pharmacogenomics of clozapine in an ancestrally diverse sample: A longitudinal analysis and GWAS using clinical monitoring data from the UK

Autor: Antonio F. Pardiñas, Djenifer B. Kappel, Milly Roberts, Francesca Tipple, Lisa M. Shitomi-Jones, Adrian King, John Jansen, Marinka Helthuis, Michael J. Owen, Michael C. O’Donovan, James T.R. Walters

BackgroundThe antipsychotic clozapine is the only drug with proven effectiveness against the treatment-resistant symptoms that affect 20-30% of those with schizophrenia. Despite this, clozapine is markedly under-prescribed, partly due to concerns abo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8ad07a19110bab4b8465be85370b3728
https://doi.org/10.1101/2022.09.23.22280299

Investigation of convergent and divergent genetic influences underlying schizophrenia and alcohol use disorder

Autor: Howard J. Edenberg, Alison Goate, Manav Kapoor, Michael Conlon O'Donovan, Tim B. Bigdeli, Dongbing Lai, Ayman H. Fanous, Henry R. Kranzler, Hang Zhou, James T.R. Walters, Emma C. Johnson, Sarah M. Hartz, Renato Polimanti, Jacquelyn L. Meyers, Carlos N. Pato, Alexander S. Hatoum, Roseann E. Peterson, Joel Gelernter, Raymond K. Walters, Stephan Ripke, Frank R. Wendt, Arpana Agrawal, Rachel L. Kember, Michele T. Pato

Publikováno v: Psychol Med

BackgroundAlcohol use disorder (AUD) and schizophrenia (SCZ) frequently co-occur, and large-scale genome-wide association studies (GWAS) have identified significant genetic correlations between these disorders.MethodsWe used the largest published GWA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::409e24a7e581088e8a7287ff9949597a
https://doi.org/10.1017/s003329172100266x