Zobrazeno 1 - 10
of 67
pro vyhledávání: '"James T. Wilson"'
Publikováno v:
International Journal of Health Geographics, Vol 17, Iss 1, Pp 1-10 (2018)
Abstract A PubMed query run in June 2018 using the keyword ‘blockchain’ retrieved 40 indexed papers, a reflection of the growing interest in blockchain among the medical and healthcare research and practice communities. Blockchain’s foundations
Externí odkaz:
https://doaj.org/article/5149147847ac4ed9a33507751ea8582b
Autor:
Thomas D Townsley, James T Wilson, Harrison Akers, Timothy Bryant, Salvador Cordova, T L Wallace, Kirk K Durston, Joseph E Deweese
Publikováno v:
Bioinformatics Advances. 2
Motivation AlphaFold has been a major advance in predicting protein structure, but still leaves the problem of determining which sub-molecular components of a protein are essential for it to carry out its function within the cell. Direct coupling ana
Publikováno v:
Chemical Research in Toxicology. 31:137-144
Topoisomerase II is a critical enzyme in replication, transcription, and the regulation of chromatin topology. Several anticancer agents target topoisomerases in order to disrupt cell growth. Cannabidiol is a major non-euphoriant, pharmacologically a
Autor:
Xiaohua Jiang, Jennifer D Conner, James T. Wilson, Joseph E. Deweese, J. Myles Keck, Edward C. Lisic
Publikováno v:
Chemical research in toxicology. 32(10)
Topoisomerase II is a nuclear enzyme involved in the maintenance of DNA and is an effective anticancer drug target. However, several clinical topoisomerase II-targeted agents display significant off-target toxicities and adverse events. Thus, it is i
Autor:
Joseph E. Deweese, Cole A. Fief, James T. Wilson, Jacob M. Keck, Kristine G. Hoang, Renee A. Menzie, Salvador Cordova, Chase W. Nelson, Carmen A. Ayes
Publikováno v:
The FASEB Journal. 33
Topoisomerase II is a critical enzyme involved in unknotting and detangling DNA during replication, transcription, and cell division. Humans have two isoforms of topoisomerase II, α (Top2A) and β (...
Autor:
James T. Wilson, Xiaohua Jiang, Tao Yu, Florence Fabunmi, Wathsala Medawala, Joseph E. Deweese, Jennifer D Conner, Derek J. Cashman, Anthony R Brown, Lana Ngo, William H. Morris, Edward C. Lisic
Publikováno v:
Chemical research in toxicology. 32(1)
Our previous research has shown that α-(N)-heterocyclic thiosemicarbazone (TSC) metal complexes inhibit human topoisomerase IIα (TopoIIα), while the ligands without metals do not. To find out the structural elements of TSC that are important for i
Publikováno v:
Chemical Research in Toxicology. 29:649-658
Type II DNA topoisomerases resolve topological knots and tangles in DNA that result from routine cellular processes and are effective targets for anticancer therapeutics. To this end, thiosemicarbazones have been identified as having the ability to k
Publikováno v:
Physical Therapy in Sport. 13:97-100
To compare the bilateral strength characteristics of the wrist flexors, extensors, pronators, and supinators among baseball players.Cross-sectional.Laboratory.30 collegiate baseball players with no recent history of upper extremity injury.Bilateral p
Publikováno v:
Pediatric Neurosurgery. 37:206-209
We report a very rare case of a lumbar nerve root schwannoma presenting with torsion and infarction. The patient was a 16-year-old male presenting with severe low back pain and urinary retention following an aggressive game of hockey. Subsequent MRI