Zobrazeno 1 - 10
of 18
pro vyhledávání: '"James T. Wasicak"'
Autor:
Badr Saeed, Douglas Kalvin, Patricia Ewing, Jerome Cohen, Saul H. Rosenberg, Henry Kenneth J, James T. Wasicak, Rolf E. Swenson, Sajeev Cherian, Michael J. Mitten, John J. Larsen, Andrew Tasker, Hing L. Sham, Shi-Chung Ng
Publikováno v:
Journal of Medicinal Chemistry. 42:4844-4852
Synthesis of a library of secondary benzylic amines based on the Sebti-Hamilton type peptidomimetic farnesyltransferase (FTase) inhibitor FTI-276 (1) led to the identification of 6 as a potent enzyme inhibitor (IC(50) of 8 nM) which lacked the proble
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5780a23e1287809b0de953a41f3c66cb
https://doi.org/10.1021/jm990335v
https://doi.org/10.1021/jm990335v
Autor:
Stephen P. Arneric, Michael Williams, David J.B. Kim, David J. Anderson, Yun He, Michael W. Decker, Diana L. Donnelly-Roberts, Theresa A. Kuntzweiler, Clark A. Briggs, Mark W. Holladay, Anthony W. Bannon, James T. Wasicak, Jeffrey E. Campbell, Keith B. Ryther, Nan-Horng Lin, Marietta Piattoni-Kaplan, Michael J. Buckley
Publikováno v:
Journal of Medicinal Chemistry. 41:407-412
New members of a previously reported series of 3-pyridyl ether compounds are disclosed as novel, potent analgesic agents acting through neuronal nicotinic acetylcholine receptors. Both (R)-2-chloro-5-(2-azetidinylmethoxy)pyridine (ABT-594, 5) and its
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81d19c3874a623f054a92340ad391012
https://doi.org/10.1021/jm9706224
https://doi.org/10.1021/jm9706224
Autor:
James T. Wasicak, Richard Kasson, P Sullivan James, David J. Sweeny, Nan-Horng Lin, Yun He, J Anderson David
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 4:2389-2394
3′ and 5′-substituted pyrrolidine analogs of the potent cholinergic channel activator (ChCA), 3-methyl-5-(2(S)-pyrrolidinyl)-isoxazole (ABT 418), 1, were synthesized and tested in vitro for cholinergic channel receptor binding activity. Since the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c47416a85ab6082db4a48bb554bd1c25
https://doi.org/10.1016/s0960-894x(01)80396-6
https://doi.org/10.1016/s0960-894x(01)80396-6
Autor:
Michael J. Buckley, Stephen P. Arneric, James P. Sullivan, George M. Carrera, David S. Garvey, Michael W. Decker, Michael Williams, Jorge D. Brioni, Mark W. Holladay, James T. Wasicak
Publikováno v:
Journal of Medicinal Chemistry. 37:1055-1059
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f3e4ff90608fda742decccc1ff7ed74
https://doi.org/10.1021/jm00034a002
https://doi.org/10.1021/jm00034a002
Autor:
James T. Wasicak, John Y. L. Chung
Publikováno v:
ChemInform. 22
Application of the Corey-Fuchs reaction on Boc-prolinal, Boc-4-hydroxyprolinal, Bocpiperidinal and Boc-serinal derivatives to give chiral 2-pyrrolidinyl-, 2-piperidinyl- and 4-oxazolidinyl-acetylene derivatives provided rapid access to a number of di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::78fcd169e7eb65aca2956bd6ee65fdf6
https://doi.org/10.1002/chin.199137148
https://doi.org/10.1002/chin.199137148
Autor:
James T. Wasicak, Michael Williams, D. S. Garvey, James P. Sullivan, Diana L. Donnelly-Roberts, Mark W. Holladay, Nan-Horng Lin, David E. Gunn, David J. Anderson, Yvonne C. Martin, P. A. Pavlik, Ann-Marie Hettinger, M. A. Abreo, Stephen P. Arneric
Publikováno v:
ChemInform. 27
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::04a12b4bab7ab7c68b88f143e80dd314
https://doi.org/10.1002/chin.199623147
https://doi.org/10.1002/chin.199623147
Publikováno v:
Synthetic Communications. 22:1039-1048
The thermal lactamization of 4-(carboethoxy)-methyl-tryptophan ethyl ester (5), prepared from 4-(carboethoxy)methyl-indole 3 via Gilchrist′s method, in refluxing xylene followed by saponification provided the 8-membered cyclic tryptophan derivative
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d35db67e1f757aa58b15920f074b4f38
https://doi.org/10.1080/00397919208019295
https://doi.org/10.1080/00397919208019295
Autor:
James T. Wasicak, John Y. L. Chung
Publikováno v:
Tetrahedron Letters. 31:3957-3960
Application of the Corey-Fuchs reaction on Boc-prolinal, Boc-4-hydroxyprolinal, Bocpiperidinal and Boc-serinal derivatives to give chiral 2-pyrrolidinyl-, 2-piperidinyl- and 4-oxazolidinyl-acetylene derivatives provided rapid access to a number of di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f372debaf43a82bd58e50252437570c4
https://doi.org/10.1016/s0040-4039(00)94471-x
https://doi.org/10.1016/s0040-4039(00)94471-x
Autor:
John Y. L. Chung, James T. Wasicak, Mark W. Holladay, William A. Arnold, Alex M. Nadzan, Catherine S. May
Publikováno v:
The Journal of Organic Chemistry. 55:270-275
La modification apportee dans la synthese de prolines substituees en 3 consiste en l'utilisation de triethyl silane et d'acide trifluoro acetique pour la reduction des pyrrolidine dicarboxylates-2,2 initiaux, et en la protection du N des prolines par
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::030b306f31067343d0f99f229b991f40
https://doi.org/10.1021/jo00288a045
https://doi.org/10.1021/jo00288a045
Autor:
Michael J. Dart, James T. Wasicak, Keith B. Ryther, Michael R. Schrimpf, Ki H. Kim, David J. Anderson, James P. Sullivan, Michael D. Meyer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f09f887cf1c865010a885462081ec39b
https://doi.org/10.1016/s0165-7208(00)80007-0
https://doi.org/10.1016/s0165-7208(00)80007-0
