Zobrazeno 1 - 10
of 48
pro vyhledávání: '"James T. Stevens"'
Autor:
John M. Clark, David M. Soderlund, Larry P. Sheets, Linda S. Mullin, Vincent J Piccirillo, Dana Sargent, Myra L. Weiner, James T Stevens
Publikováno v:
Toxicology. 171:3-59
The Food Quality Protection Act (FQPA) of 1996 requires the United States Environmental Protection Agency to consider the cumulative effects of exposure to pesticides having a 'common mechanism of toxicity.' This paper reviews the information availab
Publikováno v:
Journal of Toxicology and Environmental Health, Part A. 56:69-109
An extensive safety database has been developed for the chlorotriazine herbicide, atrazine. The results from five oncogenicity studies conducted in the Sprague-Dawley rat, two studies in the Fischer 344 rat, and two studies in the CD-1 mouse were rev
Publikováno v:
Journal of Toxicology and Environmental Health, Part B. 1:59-79
The capacity of some synthetic chemicals, the so-called "endocrine-disrupting chemical," to alter hormonal activity, as well as the adequacy of the testing of chemicals to evaluate this capacity, has been called into question. Among the chemicals ind
Publikováno v:
Journal of Toxicology and Environmental Health. 50:415-431
Recently, a major topic of discussion has been the impact of synthetic chemicals that possess the capacity to alter hormonal activity, the so-called “endocrine modulators,” with potentially the capacity to alter the reproductive capability of hum
Publikováno v:
Journal of Toxicology and Environmental Health Part A. 50:415-431
Autor:
Claude L. Hughes, James T. Stevens, George P. Daston, William R. Kelce, Rex A. Hess, Robert E. Chapin
Publikováno v:
Toxicological Sciences. 29:1-17
The ability of foreign compounds to affect the functioning of various endocrine systems is currently thought responsible for a wide variety of effects. The presentations in this Symposium reviewed the evidence for and against the involvement of endoc
Publikováno v:
Environmental Health Perspectives
Chlorotriazines are widely used in agriculture as broadleaf herbicides. The compounds specifically inhibit photosynthesis, and, as such, display little interaction with animal systems. However, a 24-month feeding study with atrazine (ATR) revealed a
Autor:
Charles B. Breckenridge, Lawrence T. Wetzel, M K Tennant, James T. Stevens, D S Hill, J C Eldridge
Publikováno v:
Journal of Toxicology and Environmental Health. 43:197-211
In an accompanying article (see pp. 183-196), it was reported that administration of very high doses of the chlorotriazine herbicides atrazine, simazine, and diaminochlorotriazine (DACT), a common metabolite, expressed antiestrogenic activity in uter
Autor:
L G Luempert rd, D G Fleenor-Heyser, J C Eldridge, James T. Stevens, J H Gillis, Lawrence T. Wetzel, P C Extrom, Charles B. Breckenridge
Publikováno v:
Journal of Toxicology and Environmental Health. 43:155-167
Atrazine or simazine (s-chlorotriazines) was administered by gavage daily for 2 wk to female Sprague-Dawley and Fischer 344 rats at oral doses of 100 or 300 mg/kg to evaluate effects on body, ovary, uterus, and adrenal weights, estrous cycle stages,
Autor:
James T. Stevens, Lawrence T. Wetzel, Jacqueline H. Gillis, Louis G. Luempert, Charles B. Breckenridge, J. Charles Eldridge
Publikováno v:
Journal of Toxicology and Environmental Health. 43:139-153
The symmetrical triazine herbicides have been used for the preemergence control of broadleaf weeds for nearly three decades. Recently, certain members of this class, primarily the chlorotriazines (substituted in the 2 position), have been shown to ev