Zobrazeno 1 - 10
of 58
pro vyhledávání: '"James T. Slama"'
Publikováno v:
Bioorganicmedicinal chemistry. 76
A photo-clickable analog of adenosine was devised and synthesized in which the photoactive functional group (8-azidoadenosine) and the click moiety (2'-O-propargyl-ether) were compactly combined within the structure of the adenosine nucleoside itself
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::025afb92b9a6a85187ca65b69194b08c
https://pubmed.ncbi.nlm.nih.gov/36446271
https://pubmed.ncbi.nlm.nih.gov/36446271
Publikováno v:
Bioorganic & Medicinal Chemistry. 76:117099
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::54d8dcc411ace9326aca7ebe6ec403dd
https://doi.org/10.1016/j.bmc.2022.117099
https://doi.org/10.1016/j.bmc.2022.117099
Publikováno v:
Trends Biochem Sci
Trends in biochemical sciences, vol 47, iss 3
Trends in biochemical sciences, vol 47, iss 3
Nicotinic acid adenine dinucleotide phosphate (NAADP) is a second messenger that releases Ca(2+) from endosomes and lysosomes by activating ion channels called two-pore channels (TPCs). However, no NAADP-binding site has been identified on TPCs. Rath
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3a0a20d5d6bd2827a36b456a4aa29fd
https://europepmc.org/articles/PMC8840967/
https://europepmc.org/articles/PMC8840967/
Publikováno v:
Biochim Biophys Acta Mol Cell Res
Nicotinic acid adenine dinucleotide phosphate is an evolutionarily conserved second messenger, which mobilizes Ca(2+) from acidic stores. The molecular identity of the NAADP receptor has yet to be defined. In pursuit of isolating and identifying NAAD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76a7f81cae9365da44513e98bd1385dc
https://doi.org/10.1016/j.bbamcr.2018.11.017
https://doi.org/10.1016/j.bbamcr.2018.11.017
Autor:
Timothy F. Walseth, Sandip Patel, Ellen M. Unterwald, Eugen Brailoiu, Shijun He, Gihan S. Gunaratne, James T. Slama, Jonathan S. Marchant
Publikováno v:
Sci Signal
Nicotinic acid adenine dinucleotide phosphate (NAADP) is a second messenger that releases Ca(2+) from acidic organelles through the activation of two pore channels (TPCs) to regulate endolysosomal trafficking events. NAADP action is mediated by NAADP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd7445918735db09e2fd440943130b69
https://doi.org/10.1126/scisignal.abd5605
https://doi.org/10.1126/scisignal.abd5605
Autor:
Qasim Alhadidi, Zahoor A. Shah, L. M. Viranga Tillekeratne, Ayad A. Al-Hamashi, Saroopa Samaradivakara, William R. Taylor, Radhika Samarasekera, O.V.D.S. Jagathpriya Weerasena, James T Slama, Shiroma M. Handunnetti, Lalith Perera
Publikováno v:
Journal of Natural Products. 81:1693-1700
A new resveratrol trimer, vateriferol (1), having four cis-oriented methine protons and constituting four contiguous stereocenters, was isolated from the bark extract of Vateria copallifera by bioassay-guided fractionation using a combination of norm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caf5b4d171c772b623172c522ee8684c
https://doi.org/10.1021/acs.jnatprod.7b00892
https://doi.org/10.1021/acs.jnatprod.7b00892
Autor:
Timothy F. Walseth, James T. Slama, Timnit Yosef Asfaha, Malcolm E. Johns, Jonathan S. Marchant, Gihan S. Gunaratne
Publikováno v:
Cell Calcium
Nicotinic acid adenine dinucleotide phosphate (NAADP) is a potent Ca(2+) mobilizing second messenger which triggers Ca(2+) release in both sea urchin egg homogenates and in mammalian cells. The NAADP binding protein has not been identified and the re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba6dc8430851751bfa33be244436d826
https://pubmed.ncbi.nlm.nih.gov/31442840
https://pubmed.ncbi.nlm.nih.gov/31442840
Autor:
James T. Slama, Eugen Brailoiu, Shijun He, Gihan S. Gunaratne, Timothy F. Walseth, Jonathan S. Marchant, Sandip Patel
Publikováno v:
Biophysical Journal. 120:54a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::35dd697ea23c1744b6afa3be70cb37d8
https://doi.org/10.1016/j.bpj.2020.11.562
https://doi.org/10.1016/j.bpj.2020.11.562
Autor:
James T. Slama, Jonathan S. Marchant, Timothy F. Walseth, Gihan S. Gunaratne, James D. Bretz, Peiling Su
Publikováno v:
Bioorg Med Chem
Nicotinamide adenine dinucleotide phosphate (NADP) is an indispensable metabolic co-substrate and nicotinic acid adenine dinucleotide phosphate (NAADP) is an important Ca(2+) releasing intracellular second messenger. Exploration of the NADP and NAADP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e8760eda5ab029390c9175a9ffe7438
https://doi.org/10.1016/j.bmc.2020.115901
https://doi.org/10.1016/j.bmc.2020.115901
Autor:
James T. Slama, Christina Camick, Katherine Wiles, Ramadan A. Ali, Sumit Bhattacharya, Timothy F. Walseth, Katherine A. Wall, David R. Giovannucci
Publikováno v:
Journal of Biological Chemistry. 291:4503-4522
Nicotinic acid adenine dinucleotide phosphate (NAADP), the most potent Ca(2+) mobilizing second messenger discovered to date, has been implicated in Ca(2+) signaling in some lymphomas and T cell clones. In contrast, the role of NAADP in Ca(2+) signal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48bb181f5998b5003295fac4e2aa0b0c
https://doi.org/10.1074/jbc.m115.681833
https://doi.org/10.1074/jbc.m115.681833