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of 130
pro vyhledávání: '"James T. Patterson"'
Autor:
James T. Patterson
In Restless Giant, acclaimed historical author James Patterson provides a crisp, concise assessment of the twenty-seven years between the resignation of Richard Nixon and the election of George W. Bush in a sweeping narrative that seamlessly weaves t
Autor:
James T. Patterson
2004 marks the fiftieth anniversary of the Supreme Court's unanimous decision to end segregation in public schools. Many people were elated when Supreme Court Chief Justice Earl Warren delivered Brown v. Board of Education of Topeka in May 1954, the
Autor:
James T. Patterson
This new edition of Patterson's widely used book carries the story of battles over poverty and social welfare through what the author calls the'amazing 1990s,'those years of extraordinary performance of the economy. He explores a range of issues aris
Autor:
James T. Patterson
Little has been written about the New Deal's effect at the state level. How did the states act before the New Deal? Did the Roosevelt administration promote progressive policies on the state level? Did it destroy state initiative? Was it discriminato
Autor:
James T. Patterson
Cancer is that “loathsome beast, which seized upon the breast, drove its long claws into the surrounding tissues, derived its sustenance by sucking out the juices of its victims, and never even relaxed its hold in death,” a turn-of-the-century ph
Autor:
Suzanne Edavettal, Pilar Cejudo-Martin, Bidisha Dasgupta, Danlin Yang, Matthew D. Buschman, Derrick Domingo, Kristof Van Kolen, Pharavee Jaiprasat, Renata Gordon, Keith Schutsky, Brian Geist, Natalie Taylor, Camille Helene Soubrane, Elisabeth Van Der Helm, Ann LaCombe, Zemeda Ainekulu, Eilyn Lacy, Jason Aligo, Jason Ho, Yingbo He, Peter F. Lebowitz, James T. Patterson, Justin M. Scheer, Sanjaya Singh
Publikováno v:
Med (New York, N.Y.). 3(12)
The near impermeability of the blood-brain barrier (BBB) and the unique neuroimmune environment of the CNS prevents the effective use of antibodies in neurological diseases. Delivery of biotherapeutics to the brain can be enabled through receptor-med
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3625ab074d5c8dc48910447704b3c93b
https://pubmed.ncbi.nlm.nih.gov/36495860
https://pubmed.ncbi.nlm.nih.gov/36495860
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e85755 (2014)
Transcription activator-like (TAL) effector nucleases (TALENs) have enabled the introduction of targeted genetic alterations into a broad range of cell lines and organisms. These customizable nucleases are comprised of programmable sequence-specific
Externí odkaz:
https://doaj.org/article/826d5b79bea141b3bb296bc79913bb84
Autor:
Rohit Duggal, Jason Isaacson, Heyue Zhou, James T. Patterson, Yanwen Fu, Tong Zhu, Gunnar F. Kaufmann, Ghazi Atassi, Lisa Kerwin, Damien Bresson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:5490-5495
Bioconjugate formats provide alternative strategies for antigen targeting with bispecific antibodies. Here, PSMA-targeted Fab conjugates were generated using different bispecific formats. Interchain disulfide bridging of an αCD3 Fab enabled installa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb8c4906ce0bafb63d6fafbe888c3519
https://doi.org/10.1016/j.bmcl.2017.09.065
https://doi.org/10.1016/j.bmcl.2017.09.065
Publikováno v:
PLoS ONE, Vol 5, Iss 8, p e12368 (2010)
BACKGROUND: In vitro selection of kinase ribozymes for small molecule metabolites, such as free nucleosides, will require partition systems that discriminate active from inactive RNA species. While nucleic acid catalysis of phosphoryl transfer is wel
Externí odkaz:
https://doaj.org/article/55e3316d4b00498294adad62b383b79c
Autor:
James T. Patterson, Gunnar F. Kaufmann, Heyue Zhou, Tong Zhu, Bryan Jones, Ghazi Atassi, Lisa Kerwin, Lisa Carmody, Edwige Gros, Yanwen Fu
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:3647-3652
Bispecific antibodies (BsAbs) are designed to engage two antigens simultaneously, thus, effectively expanding the ability of antibody-based therapeutics to target multiple pathways within the same cell, engage two separate soluble antigens, bind the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02b519269b029bf1a38f25eb5bf72780
https://doi.org/10.1016/j.bmcl.2017.07.021
https://doi.org/10.1016/j.bmcl.2017.07.021