Zobrazeno 1 - 10
of 60
pro vyhledávání: '"James T. Lynch"'
Autor:
Alba Maiques-Diaz, Gary J. Spencer, James T. Lynch, Filippo Ciceri, Emma L. Williams, Fabio M.R. Amaral, Daniel H. Wiseman, William J. Harris, Yaoyong Li, Sudhakar Sahoo, James R. Hitchin, Daniel P. Mould, Emma E. Fairweather, Bohdan Waszkowycz, Allan M. Jordan, Duncan L. Smith, Tim C.P. Somervaille
Publikováno v:
Cell Reports, Vol 22, Iss 13, Pp 3641-3659 (2018)
Summary: Pharmacologic inhibition of LSD1 promotes blast cell differentiation in acute myeloid leukemia (AML) with MLL translocations. The assumption has been that differentiation is induced through blockade of LSD1’s histone demethylase activity.
Externí odkaz:
https://doaj.org/article/62c57f81e288426abeec246fcdba9441
Publikováno v:
Molecular & Cellular Oncology, Vol 5, Iss 4 (2018)
Pharmacologic inhibition of KDM1A (Lysine Demethylase 1A) induces differentiation in certain subtypes of acute myeloid leukemia. Our recent studies reveal this is dependent upon drug-induced disruption of the GFI1 (Growth Factor Independent 1) transc
Externí odkaz:
https://doaj.org/article/54c03ffaaa5844b88e4542acc79a378c
Autor:
Simon T. Barry, Francisco Cruzalegui, Susan E. Critchlow, Teresa Klinowska, Marie Cumberbatch, Alvaro Avivar-Valderas, Radoslaw Polanski, Carol Lenaghan, Catherine Eberlein, Catherine Trigwell, Juliana Maynard, Oona Delpuech, Ursula Hancox, Urszula M. Polanska, James T. Lynch
Supp Fig 1 Tumour efficacy Supp Fig 2 In vitro gene expression modulation Supp Fig 3 In vivo biomarker analysis Supp Fig 4 HCC70 In vivo FDG uptake imaging Supp Fig 5 U87MG in vivo FDG uptake imaging
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a49696169a1bdafab82b251d9a41f65
https://doi.org/10.1158/1535-7163.22505517.v1
https://doi.org/10.1158/1535-7163.22505517.v1
Autor:
Simon T. Barry, Francisco Cruzalegui, Susan E. Critchlow, Teresa Klinowska, Marie Cumberbatch, Alvaro Avivar-Valderas, Radoslaw Polanski, Carol Lenaghan, Catherine Eberlein, Catherine Trigwell, Juliana Maynard, Oona Delpuech, Ursula Hancox, Urszula M. Polanska, James T. Lynch
Loss of the tumor suppressor PTEN confers a tumor cell dependency on the PI3Kβ isoform. Achieving maximal inhibition of tumor growth through PI3K pathway inhibition requires sustained inhibition of PI3K signaling; however, efficacy is often limited
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3b3a8efc07d530f0362f410fd03bbc96
https://doi.org/10.1158/1535-7163.c.6538098.v1
https://doi.org/10.1158/1535-7163.c.6538098.v1
Autor:
Simon T. Barry, Francisco Cruzalegui, Susan E. Critchlow, Teresa Klinowska, Marie Cumberbatch, Alvaro Avivar-Valderas, Radoslaw Polanski, Carol Lenaghan, Catherine Eberlein, Catherine Trigwell, Juliana Maynard, Oona Delpuech, Ursula Hancox, Urszula M. Polanska, James T. Lynch
Supplementary Table 1: Cell lines; Supplementary Table 2: Antibodies; Supplementary Table 3: Gene lists
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91db55cea79f8877939d98d6dd7b2313
https://doi.org/10.1158/1535-7163.22505511
https://doi.org/10.1158/1535-7163.22505511
Autor:
Simon T. Barry, Francisco Cruzalegui, Susan E. Critchlow, Marie Cumberbatch, Anna Staniszewska, James Pilling, Alvaro Avivar-Valderas, Rebecca Ellston, Radek Polanski, James Bradford, Robert McEwen, Carol Lenaghan, Filippos Michopoulos, Antonio G. Trinidad, Urs Hancox, Oona Delpuech, Urszula M. Polanska, James T. Lynch
Supplemtary figures 1-9
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0254ee54451d26a1e2706aaccbaf44f8
https://doi.org/10.1158/1078-0432.22463216.v1
https://doi.org/10.1158/1078-0432.22463216.v1
Autor:
Simon T. Barry, Francisco Cruzalegui, Susan E. Critchlow, Marie Cumberbatch, Anna Staniszewska, James Pilling, Alvaro Avivar-Valderas, Rebecca Ellston, Radek Polanski, James Bradford, Robert McEwen, Carol Lenaghan, Filippos Michopoulos, Antonio G. Trinidad, Urs Hancox, Oona Delpuech, Urszula M. Polanska, James T. Lynch
Supplementary Table results
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e38fe420d400c7fb1812b394c0d16e8
https://doi.org/10.1158/1078-0432.22463210.v1
https://doi.org/10.1158/1078-0432.22463210.v1
Autor:
Simon T. Barry, Francisco Cruzalegui, Susan E. Critchlow, Marie Cumberbatch, Anna Staniszewska, James Pilling, Alvaro Avivar-Valderas, Rebecca Ellston, Radek Polanski, James Bradford, Robert McEwen, Carol Lenaghan, Filippos Michopoulos, Antonio G. Trinidad, Urs Hancox, Oona Delpuech, Urszula M. Polanska, James T. Lynch
Supplementary Table Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b69d7b0c7f1ef99c6856bb17319c451d
https://doi.org/10.1158/1078-0432.22463213
https://doi.org/10.1158/1078-0432.22463213
Autor:
Simon T. Barry, Francisco Cruzalegui, Susan E. Critchlow, Marie Cumberbatch, Anna Staniszewska, James Pilling, Alvaro Avivar-Valderas, Rebecca Ellston, Radek Polanski, James Bradford, Robert McEwen, Carol Lenaghan, Filippos Michopoulos, Antonio G. Trinidad, Urs Hancox, Oona Delpuech, Urszula M. Polanska, James T. Lynch
Purpose: PTEN-null tumors become dependent on the PI3Kβ isoform and can be targeted by molecules such as the selective PI3Kβ inhibitor AZD8186. However, beyond the modulation of the canonical PI3K pathway, the consequences of inhibiting PI3Kβ are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e357256d933e04d7180466b15cfa0a8
https://doi.org/10.1158/1078-0432.c.6525344
https://doi.org/10.1158/1078-0432.c.6525344
Autor:
Simon T. Barry, Francisco Cruzalegui, Susan E. Critchlow, Marie Cumberbatch, Anna Staniszewska, James Pilling, Alvaro Avivar-Valderas, Rebecca Ellston, Radek Polanski, James Bradford, Robert McEwen, Carol Lenaghan, Filippos Michopoulos, Antonio G. Trinidad, Urs Hancox, Oona Delpuech, Urszula M. Polanska, James T. Lynch
Supplemental data figure legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15e8dfb1623fe8e4b2a1b39597fe34ae
https://doi.org/10.1158/1078-0432.22463222
https://doi.org/10.1158/1078-0432.22463222