Zobrazeno 1 - 10
of 17
pro vyhledávání: '"James T. Downs"'
Autor:
Howard M. Weiss, James T. Downs
Publikováno v:
Journal of Shellfish Research. 39:461
Long Island Sound (LIS) is near the northern limit for the range of year-round populations of the blue crab Callinectes sapidus (Rathbun, 1896). This study sampled blue crabs for 7 y with a trawl in LIS and with traps in the estuarine portion of thre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8f473c4b77f3c69ff548f251eae44162
https://doi.org/10.2983/035.039.0227
https://doi.org/10.2983/035.039.0227
Autor:
Mary Piotrowski, Allen J. Duplantier, Christine A. Strick, Brian D. Harvey, Mark J. Majchrzak, Cheryl Li, Patricia A. Seymour, Christopher J. Schmidt, Carol B. Fox, Alan H. Ganong, Larry C. James, F. David Tingley, Andres D. Ramirez, James T. Downs, Mihály Hajós, Victor Guanowsky, Liam Scott, Stacey L. Becker, Youfen Xu, Stefanus J. Steyn, Ayman El-Kattan, Brian Rago
Publikováno v:
Neuropharmacology. 61:1001-1015
Observations that N-Methyl-D-Aspartate (NMDA) antagonists produce symptoms in humans that are similar to those seen in schizophrenia have led to the current hypothesis that schizophrenia might result from NMDA receptor hypofunction. Inhibition of D-a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29d50eb849564a55d05e9986564219f8
https://doi.org/10.1016/j.neuropharm.2011.06.029
https://doi.org/10.1016/j.neuropharm.2011.06.029
Autor:
James T. Downs, Joseph M. Merenda, Marcia L. Bliven, Ivan G. Otterness, Merton G. Gollaher, Gaston O. Daumy, Timothy J. Zuzel
Publikováno v:
Biochemical Pharmacology. 52:917-925
In vitro pharmacologic measures of drug specificity are well established, i.e. drug interaction with a specific target such as an enzyme, receptor, or ion channel. However, in vitro measures of drug selectivity, defined as effects on secondary target
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8a85c9268a6c076173b4b117bdb7d7ab
https://doi.org/10.1016/0006-2952(96)00448-0
https://doi.org/10.1016/0006-2952(96)00448-0
Autor:
Allen J. Duplantier, Victoria A. Williams, James T. Downs, Stefanus J. Steyn, Subas M. Sakya, Jiemin Lu, Boris A. Chrunyk, Lain-Yen Hu, Noha Maklad, Lei Zhang, Michael John Bohanon, Stacey L. Becker, Christine A. Strick, Shenping Liu, Mary Piotrowski, Scot Richard Mente, Ayman El-Kattan, Sheehan Susan M, Mahmoud N. Mansour, Kris A. Borzilleri, Larry C. James
Publikováno v:
Journal of medicinal chemistry. 52(11)
3-Hydroxyquinolin-2(1H)-one (2) was discovered by high throughput screening in a functional assay to be a potent inhibitor of human DAAO, and its binding affinity was confirmed in a Biacore assay. Cocrystallization of 2 with the human DAAO enzyme def
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdf9ac2ceb83f75089e9eff06cce29e1
https://pubmed.ncbi.nlm.nih.gov/19438227
https://pubmed.ncbi.nlm.nih.gov/19438227
Publikováno v:
Cytokine. 3:277-283
Tenidap is a new antiarthritic drug of novel chemical structure. This study shows the effects of tenidap on the in vitro synthesis of interleukin 1 (IL-1). IL-1 production by murine peritoneal macrophages was induced either by stimulation with lipopo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3136568586cb3c0761598eaeec3573ac
https://doi.org/10.1016/1043-4666(91)90495-y
https://doi.org/10.1016/1043-4666(91)90495-y
Autor:
James T. Downs
Publikováno v:
Disability Studies Quarterly. 28
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::322b69b831b03a7bad781ad273728fb2
https://doi.org/10.18061/dsq.v28i3.112
https://doi.org/10.18061/dsq.v28i3.112
Autor:
Mark C. Noe, Elaine M. Greer, Usa Reilly, Lilli A. Wolf-Gouviea, Roberto E. Guzman, David J. Garmene, Christopher S. Jones, Lawrence A. Reiter, Donald G. Robertson, Amy S. Antipas, Ellen R. Laird, James D. Eskra, James T. Downs, Jennifer L. Liras, Sue A. Yocum, Gary J. Martinelli, Fouad Janat, Lori L. Lopresti-Morrow, Kevin Daniel Freeman-Cook, Marcie L. Vaughn-Bowser, Dennis E. Danley, Peter G. Mitchell, Jayvardhan Pandit, Shane A. Eisenbeis, Joel R. Hardink, Kaushik Datta, R. J. Griffiths
Publikováno v:
Bioorganicmedicinal chemistry letters. 17(23)
Explorations in the pyrimidinetrione series of MMP-13 inhibitors led to the discovery of a series of spiro-fused compounds that are potent and selective inhibitiors of MMP-13. While other spiro-fused motifs are hydrolytically unstable, presumably due
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61bea8c2e0b8d2cf579311fdcfbe4ed8
https://pubmed.ncbi.nlm.nih.gov/17935984
https://pubmed.ncbi.nlm.nih.gov/17935984
Autor:
Lori L. Lopresti-Morrow, Kevin Daniel Freeman-Cook, Joel R. Hardink, Elaine M. Greer, Amy S. Antipas, Gary J. Martinelli, Jennifer L. Liras, Fouad Janat, Donald G. Robertson, Jayvardhan Pandit, Kaushik Datta, Sue A. Yocum, James T. Downs, Darra M. Waller, Diana Sperger, Lawrence A. Reiter, Ellen R. Laird, Martin A. Berliner, Peter G. Mitchell, Michael D. Forman, Marcie L. Vaughn-Bowser, James D. Eskra, Nandell F. Keene, Roberto E. Guzman, Christopher S. Jones
Publikováno v:
Bioorganicmedicinal chemistry letters. 16(22)
Using SAR from two related series of pyrimidinetrione-based inhibitors, compounds with potent MMP-13 inhibition and >100-fold selectivity against other MMPs have been identified. Despite high molecular weights, c log Ps, and polar surface areas, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a677dbc57c5181a3a9927f482718a66
https://pubmed.ncbi.nlm.nih.gov/16942871
https://pubmed.ncbi.nlm.nih.gov/16942871
Autor:
Christopher S. Jones, Jennifer L. Liras, Sue A. Yocum, Joel R. Hardink, Shang-Poa P. Chang, Julian Blagg, Lilli Ann Wolf-Gouveia, Ralph P. Robinson, Mark C. Noe, Peter G. Mitchell, Nancy C. Elliott, Amber I. Haugeto, Jayvardhan Pandit, R. J. Griffiths, Ellen R. Laird, Lawrence A. Reiter, James D. Eskra, Marcie L. Vaughn-Bowser, Chakrapani Subramanyam, James T. Downs, Lori L. Lopresti-Morrow, Dennis E. Danley
Publikováno v:
Bioorganicmedicinal chemistry letters. 15(7)
Through the use of computational modeling, a series of pyrimidinetrione-based inhibitors of MMP-13 was designed based on a lead inhibitor identified through file screening. Incorporation of a biaryl ether moiety at the C-5 position of the pyrimidinet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c1b93251818383c7c6286b45657c782
https://pubmed.ncbi.nlm.nih.gov/15780611
https://pubmed.ncbi.nlm.nih.gov/15780611
Autor:
Caryl Lane, Jean-Pierre Pelletier, George A. Karam, Nestor B Nestor, Michele A. Kelly, James T. Downs, Peter S. Mezes, Thomas J. McLellan, Ivan G. Otterness
Publikováno v:
Journal of immunological methods. 247(1-2)
We have developed monoclonal antibody 5109 against a unique highly acidic sequence in type II collagen. When paired with previously reported monoclonal antibody 9A4, 5109 can be used as the capture antibody in an ELISA assay for the neoepitope genera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7aaa5ccc946e52de77dd7f155ff0b1eb
https://pubmed.ncbi.nlm.nih.gov/11150534
https://pubmed.ncbi.nlm.nih.gov/11150534