Zobrazeno 1 - 10
of 82
pro vyhledávání: '"James T Yurkovich"'
Autor:
Bernhard O Palsson, James T Yurkovich
Publikováno v:
Molecular Systems Biology, Vol 18, Iss 2, Pp n/a-n/a (2022)
Computational biologists have labored for decades to produce kinetic models to mechanistically explain complex metabolic phenomena. The estimation of numerical values for the large number of kinetic parameters required for constructing large‐scale
Externí odkaz:
https://doaj.org/article/4d4f1fd2ef5148af9ef5f6278bdffcec
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 1, p e1008208 (2021)
Mathematical models of metabolic networks utilize simulation to study system-level mechanisms and functions. Various approaches have been used to model the steady state behavior of metabolic networks using genome-scale reconstructions, but formulatin
Externí odkaz:
https://doaj.org/article/3846a1961c114a0ab1c5d9e49137eaf3
Publikováno v:
Molecular Systems Biology, Vol 16, Iss 8, Pp n/a-n/a (2020)
Standardization of data and models facilitates effective communication, especially in computational systems biology. However, both the development and consistent use of standards and resources remain challenging. As a result, the amount, quality, and
Externí odkaz:
https://doaj.org/article/bef41c904a134a7db663ee3efc68338b
Publikováno v:
PLoS Computational Biology, Vol 14, Iss 8, p e1006356 (2018)
Allosteric regulation has traditionally been described by mathematically-complex allosteric rate laws in the form of ratios of polynomials derived from the application of simplifying kinetic assumptions. Alternatively, an approach that explicitly des
Externí odkaz:
https://doaj.org/article/236d2f241ebb48b8a06c628e29c56c0f
Publikováno v:
PLoS Computational Biology, Vol 13, Iss 3, p e1005424 (2017)
Deep-coverage metabolomic profiling has revealed a well-defined development of metabolic decay in human red blood cells (RBCs) under cold storage conditions. A set of extracellular biomarkers has been recently identified that reliably defines the qua
Externí odkaz:
https://doaj.org/article/4a2099aaafeb437081ae2cd6ee512d26
Autor:
Yue Zhang, Guangrong Qin, Boris Aguilar, Noa Rappaport, James T. Yurkovich, Lance Pflieger, Sui Huang, Leroy Hood, Ilya Shmulevich
Publikováno v:
Frontiers in Digital Health, Vol 6 (2024)
IntroductionA digital twin is a virtual representation of a patient's disease, facilitating real-time monitoring, analysis, and simulation. This enables the prediction of disease progression, optimization of care delivery, and improvement of outcomes
Externí odkaz:
https://doaj.org/article/42febbed3fe641b9be4078e0077dd232
Autor:
Freyr Jóhannsson, James T. Yurkovich, Steinn Guðmundsson, Ólafur E. Sigurjónsson, Óttar Rolfsson
Publikováno v:
Metabolites, Vol 14, Iss 2, p 91 (2024)
Temperature plays a fundamental role in biology, influencing cellular function, chemical reaction rates, molecular structures, and interactions. While the temperature dependence of many biochemical reactions is well defined in vitro, the effect of te
Externí odkaz:
https://doaj.org/article/9bfd54caf5d64a4fa3f6fc37421be371
Publikováno v:
Holland‐Frei Cancer Medicine. :1-8
Autor:
Gustavo Glusman, Eric S. Orwoll, Christian Diener, John C. Earls, Nathan D. Price, Jennifer C. Lovejoy, Andrew T. Magis, Sushmita Patwardhan, Leroy Hood, Jack Wiedrick, Jane A. Cauley, Nancy E Lane, Deborah M. Kado, Jodi Lapidus, Anat Zimmer, Joseph M. Zmuda, Sean M. Gibbons, Tomasz Wilmanski, Max Robinson, Noa Rappaport, James T. Yurkovich
Publikováno v:
Nat Metab
Nature metabolism
Nature metabolism, vol 3, iss 2
Nature metabolism
Nature metabolism, vol 3, iss 2
The gut microbiome has important effects on human health, yet its importance in human ageing remains unclear. In the present study, we demonstrate that, starting in mid-to-late adulthood, gut microbiomes become increasingly unique to individuals with
Autor:
Bernhard O. Palsson, Justin Tan, Adam M. Feist, James T. Yurkovich, Zachary A. King, Troy E. Sandberg, Patrick V. Phaneuf, David Heckmann, Muyao Wu
Publikováno v:
BMC Genomics, Vol 21, Iss 1, Pp 1-16 (2020)
Phaneuf, P V, Yurkovich, J T, Heckmann, D, Wu, M, Sandberg, T E, King, Z A, Tan, J, Palsson, B O & Feist, A M 2020, ' Causal mutations from adaptive laboratory evolution are outlined by multiple scales of genome annotations and condition-specificity ', BMC Genomics, vol. 21, 514 . https://doi.org/10.1186/s12864-020-06920-4
BMC genomics, vol 21, iss 1
BMC Genomics
Phaneuf, P V, Yurkovich, J T, Heckmann, D, Wu, M, Sandberg, T E, King, Z A, Tan, J, Palsson, B O & Feist, A M 2020, ' Causal mutations from adaptive laboratory evolution are outlined by multiple scales of genome annotations and condition-specificity ', BMC Genomics, vol. 21, 514 . https://doi.org/10.1186/s12864-020-06920-4
BMC genomics, vol 21, iss 1
BMC Genomics
Background Adaptive Laboratory Evolution (ALE) has emerged as an experimental approach to discover mutations that confer phenotypic functions of interest. However, the task of finding and understanding all beneficial mutations of an ALE experiment re