Zobrazeno 1 - 10
of 60
pro vyhledávání: '"James T Lynch"'
Autor:
Emanuel Gonçalves, Aldo Segura‐Cabrera, Clare Pacini, Gabriele Picco, Fiona M Behan, Patricia Jaaks, Elizabeth A Coker, Donny van der Meer, Andrew Barthorpe, Howard Lightfoot, Tatiana Mironenko, Alexandra Beck, Laura Richardson, Wanjuan Yang, Ermira Lleshi, James Hall, Charlotte Tolley, Caitlin Hall, Iman Mali, Frances Thomas, James Morris, Andrew R Leach, James T Lynch, Ben Sidders, Claire Crafter, Francesco Iorio, Stephen Fawell, Mathew J Garnett
Publikováno v:
Molecular Systems Biology, Vol 16, Iss 7, Pp 1-14 (2020)
Abstract Low success rates during drug development are due, in part, to the difficulty of defining drug mechanism‐of‐action and molecular markers of therapeutic activity. Here, we integrated 199,219 drug sensitivity measurements for 397 unique an
Externí odkaz:
https://doaj.org/article/8d3c7a8706894b218dbc302dbd8ec445
Autor:
Simon T. Barry, Francisco Cruzalegui, Susan E. Critchlow, Teresa Klinowska, Marie Cumberbatch, Alvaro Avivar-Valderas, Radoslaw Polanski, Carol Lenaghan, Catherine Eberlein, Catherine Trigwell, Juliana Maynard, Oona Delpuech, Ursula Hancox, Urszula M. Polanska, James T. Lynch
Supp Fig 1 Tumour efficacy Supp Fig 2 In vitro gene expression modulation Supp Fig 3 In vivo biomarker analysis Supp Fig 4 HCC70 In vivo FDG uptake imaging Supp Fig 5 U87MG in vivo FDG uptake imaging
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a49696169a1bdafab82b251d9a41f65
https://doi.org/10.1158/1535-7163.22505517.v1
https://doi.org/10.1158/1535-7163.22505517.v1
Autor:
Simon T. Barry, Francisco Cruzalegui, Susan E. Critchlow, Teresa Klinowska, Marie Cumberbatch, Alvaro Avivar-Valderas, Radoslaw Polanski, Carol Lenaghan, Catherine Eberlein, Catherine Trigwell, Juliana Maynard, Oona Delpuech, Ursula Hancox, Urszula M. Polanska, James T. Lynch
Loss of the tumor suppressor PTEN confers a tumor cell dependency on the PI3Kβ isoform. Achieving maximal inhibition of tumor growth through PI3K pathway inhibition requires sustained inhibition of PI3K signaling; however, efficacy is often limited
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3b3a8efc07d530f0362f410fd03bbc96
https://doi.org/10.1158/1535-7163.c.6538098.v1
https://doi.org/10.1158/1535-7163.c.6538098.v1
Autor:
Simon T. Barry, Francisco Cruzalegui, Susan E. Critchlow, Teresa Klinowska, Marie Cumberbatch, Alvaro Avivar-Valderas, Radoslaw Polanski, Carol Lenaghan, Catherine Eberlein, Catherine Trigwell, Juliana Maynard, Oona Delpuech, Ursula Hancox, Urszula M. Polanska, James T. Lynch
Supplementary Table 1: Cell lines; Supplementary Table 2: Antibodies; Supplementary Table 3: Gene lists
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91db55cea79f8877939d98d6dd7b2313
https://doi.org/10.1158/1535-7163.22505511
https://doi.org/10.1158/1535-7163.22505511
Autor:
Simon T. Barry, Francisco Cruzalegui, Susan E. Critchlow, Marie Cumberbatch, Anna Staniszewska, James Pilling, Alvaro Avivar-Valderas, Rebecca Ellston, Radek Polanski, James Bradford, Robert McEwen, Carol Lenaghan, Filippos Michopoulos, Antonio G. Trinidad, Urs Hancox, Oona Delpuech, Urszula M. Polanska, James T. Lynch
Supplemtary figures 1-9
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0254ee54451d26a1e2706aaccbaf44f8
https://doi.org/10.1158/1078-0432.22463216.v1
https://doi.org/10.1158/1078-0432.22463216.v1
Autor:
Simon T. Barry, Francisco Cruzalegui, Susan E. Critchlow, Marie Cumberbatch, Anna Staniszewska, James Pilling, Alvaro Avivar-Valderas, Rebecca Ellston, Radek Polanski, James Bradford, Robert McEwen, Carol Lenaghan, Filippos Michopoulos, Antonio G. Trinidad, Urs Hancox, Oona Delpuech, Urszula M. Polanska, James T. Lynch
Supplementary Table results
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e38fe420d400c7fb1812b394c0d16e8
https://doi.org/10.1158/1078-0432.22463210.v1
https://doi.org/10.1158/1078-0432.22463210.v1
Autor:
Simon T. Barry, Francisco Cruzalegui, Susan E. Critchlow, Marie Cumberbatch, Anna Staniszewska, James Pilling, Alvaro Avivar-Valderas, Rebecca Ellston, Radek Polanski, James Bradford, Robert McEwen, Carol Lenaghan, Filippos Michopoulos, Antonio G. Trinidad, Urs Hancox, Oona Delpuech, Urszula M. Polanska, James T. Lynch
Supplementary Table Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b69d7b0c7f1ef99c6856bb17319c451d
https://doi.org/10.1158/1078-0432.22463213
https://doi.org/10.1158/1078-0432.22463213
Autor:
Simon T. Barry, Francisco Cruzalegui, Susan E. Critchlow, Marie Cumberbatch, Anna Staniszewska, James Pilling, Alvaro Avivar-Valderas, Rebecca Ellston, Radek Polanski, James Bradford, Robert McEwen, Carol Lenaghan, Filippos Michopoulos, Antonio G. Trinidad, Urs Hancox, Oona Delpuech, Urszula M. Polanska, James T. Lynch
Purpose: PTEN-null tumors become dependent on the PI3Kβ isoform and can be targeted by molecules such as the selective PI3Kβ inhibitor AZD8186. However, beyond the modulation of the canonical PI3K pathway, the consequences of inhibiting PI3Kβ are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e357256d933e04d7180466b15cfa0a8
https://doi.org/10.1158/1078-0432.c.6525344
https://doi.org/10.1158/1078-0432.c.6525344
Autor:
Simon T. Barry, Francisco Cruzalegui, Susan E. Critchlow, Marie Cumberbatch, Anna Staniszewska, James Pilling, Alvaro Avivar-Valderas, Rebecca Ellston, Radek Polanski, James Bradford, Robert McEwen, Carol Lenaghan, Filippos Michopoulos, Antonio G. Trinidad, Urs Hancox, Oona Delpuech, Urszula M. Polanska, James T. Lynch
Supplemental data figure legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15e8dfb1623fe8e4b2a1b39597fe34ae
https://doi.org/10.1158/1078-0432.22463222
https://doi.org/10.1158/1078-0432.22463222
Autor:
Nullin Divecha, Goran Landberg, Karin Jirström, James T. Lynch, Yvette Bultsma, David R. Jones, Andrew H. Sims, Willem-Jan Keune
Phosphatidylinositol-5-phosphate (PtdIns5P) 4-kinase β (PIP4K2B) directly regulates the levels of two important phosphoinositide second messengers, PtdIns5P and phosphatidylinositol-(4,5)-bisphosphate [PtdIns(4,5)P2]. PIP4K2B has been linked to the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::769d0570b29866b98de88edc422ff523
https://doi.org/10.1158/0008-5472.c.6505538
https://doi.org/10.1158/0008-5472.c.6505538