Zobrazeno 1 - 10
of 22
pro vyhledávání: '"James T Kirk"'
Autor:
Leo McHugh, Therese A Seldon, Roslyn A Brandon, James T Kirk, Antony Rapisarda, Allison J Sutherland, Jeffrey J Presneill, Deon J Venter, Jeffrey Lipman, Mervyn R Thomas, Peter M C Klein Klouwenberg, Lonneke van Vught, Brendon Scicluna, Marc Bonten, Olaf L Cremer, Marcus J Schultz, Tom van der Poll, Thomas D Yager, Richard B Brandon
Publikováno v:
PLoS Medicine, Vol 12, Iss 12, p e1001916 (2015)
Systemic inflammation is a whole body reaction having an infection-positive (i.e., sepsis) or infection-negative origin. It is important to distinguish between these two etiologies early and accurately because this has significant therapeutic implica
Externí odkaz:
https://doaj.org/article/a07d6d6c71cc4b82a59eddb9bf7995b7
Autor:
Maria Milagro Montero, Max Hardy-Werbin, Soledad Gonzalez-Gallardo, Erica Torres, Rebeca Rueda, Irene Hannet, James T. Kirk, Thomas D. Yager, Krupa Navalkar, Maria del Mar Arenas, Itziar Arietta-Aldea, Silvia Castañeda, Joan Gómez-Junyent, Silvia Gómez-Zorrilla, Roberto Guerri-Fernandez, Francisca Sanchez-Martinez, Immaculada López-Montesinos, Ivan Pelegrín, Elena Sendra, Luisa Sorlí, Judith Villar-García, Beatriz Bellosillo, Juan Pablo Horcajada
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Tools for the evaluation of COVID-19 severity would help clinicians with triage decisions, especially the decision whether to admit to ICU. The aim of this study was to evaluate SeptiCyte RAPID, a host immune response assay (Immunexpress, Se
Externí odkaz:
https://doaj.org/article/e8b3305744854eb4b0a197610c89df3a
Autor:
Victor Gravrand, François Mellot, Felix Ackermann, Marie-Christine Ballester, Benjamin Zuber, James T. Kirk, Krupa Navalkar, Thomas D. Yager, Fabien Petit, Tiffany Pascreau, Eric Farfour, Marc Vasse
Publikováno v:
Viruses, Vol 15, Iss 2, p 419 (2023)
SeptiCyte® RAPID is a gene expression assay measuring the relative expression levels of host response genes PLA2G7 and PLAC8, indicative of a dysregulated immune response during sepsis. As severe forms of COVID-19 may be considered viral sepsis, we
Externí odkaz:
https://doaj.org/article/d0e51dc7c82b4b1da23c03ecd9763265
Autor:
Maria Milagro Montero, Max Hardy-Werbin, Soledad Gonzalez Gallardo, Erica Torres, Rebeca Rueda, Irene Hannet, James T Kirk, Thomas D Yager, Krupa Navalkar, Maria del Mar Arenas, Itziar Arietta-Aldea, Silvia Castañeda, Joan Gómez-Junyent, Silvia Gómez-Zorrilla, Roberto Guerri-Fernández, Francisca Sanchez-Martinez, Immaculada López-Montesinos, Ivan Pelegrín, Elena Sendra, Luisa Sorlí, Judith Villar-García, Beatriz Bellosillo Paricio, Juan Pablo Horcajada
Rationale: Tools for the evaluation of COVID-19 severity would help clinicians with triage decisions, especially the decision whether to admit to ICU. Objective: Evaluation of SeptiCyte RAPID, a host immune response assay (Immunexpress, Seattle USA)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b79c6ac89e6adc1839ec7f8eff9b7157
https://doi.org/10.21203/rs.3.rs-1942658/v1
https://doi.org/10.21203/rs.3.rs-1942658/v1
Autor:
Robert Balk, Annette M. Esper, Greg S. Martin, Russell R. Miller, Bert K. Lopansri, John P. Burke, Mitchell Levy, Steven Opal, Richard E. Rothman, Franco R. D'Alessio, Venkataramana K. Sidhaye, Neil R. Aggarwal, Jared A. Greenberg, Mark Yoder, Gourang Patel, Emily Gilbert, Jorge P. Parada, Majid Afshar, Jordan A. Kempker, Tom van der Poll, Marcus J. Schultz, Brendon P. Scicluna, Peter M. C. Klein Klouwenberg, Janice Liebler, Emily Blodget, Santhi Kumar, Krupa Navalkar, Thomas D Yager, Dayle Sampson, James T. Kirk, Silvia Cermelli, Roy F. Davis, Richard B. Brandon
Background: SeptiCyte RAPID is a molecular test for distinguishing sepsis from non-infectious systemic inflammation. The objective of this study was the clinical validation of SeptiCyte RAPID, based on testing retrospective (banked) and prospectively
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::96dca9054ba64f43d978fcb99c9195e7
https://doi.org/10.1101/2022.07.20.22277648
https://doi.org/10.1101/2022.07.20.22277648
Autor:
James T. Kirk, Sara Yazdi, David Putnam, Kevin J. McHugh, Julius N. Korley, James M. Anderson
Publikováno v:
Biomaterials. 98:41-52
The one-step synthesis of a polyester family containing dihydroxyacetone is described along with a quantitative analysis of in vitro/in vivo degradation kinetics and initial biocompatibility. Polyesters were synthesized by combining dihydroxyacetone,
Autor:
Marcus J. Schultz, Greg S. Martin, Dayle Sampson, Thomas D. Yager, Robert A. Balk, Silvia Cermelli, Tom van der Poll, Stella Hahn, Richard E. Rothman, Antony Rapisarda, Annette M. Esper, Steven M. Opal, Jordan A. Kempker, Shruti Bhide, Brian A. Fox, Mitchell M. Levy, Richard Bruce Brandon, Roslyn A. Brandon, Neil R. Aggarwal, Adey Tsegaye, Krupa Arun Navalkar, Majid Afshar, Mark Yoder, Russell R. Miller, John P. Burke, Emily R. Gilbert, Paul H. Mayo, Victoria Rothwell, Franco R. D'Alessio, Gourang P. Patel, Therese Seldon, Venkataramana K. Sidhaye, Roy F. Davis, James T. Kirk, Brendon P. Scicluna, Mangala Narasimhan, Leo McHugh, Richard Newman, Bert K. Lopansri, Peter M. C. Klein Klouwenberg, Jared A. Greenberg, Jorge P. Parada
Publikováno v:
American journal of respiratory and critical care medicine, 198(7), 903-913. American Thoracic Society
American Journal of Respiratory and Critical Care Medicine
American Journal of Respiratory and Critical Care Medicine
A molecular test to distinguish between sepsis and systemic inflammation of noninfectious etiology could potentially have clinical utility.This study evaluated the diagnostic performance of a molecular host response assay (SeptiCyte LAB) designed to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fe86da10b4868ef23566cd09454be03
https://pure.amc.nl/en/publications/validation-of-a-host-response-assay-septicyte-lab-for-discriminating-sepsis-from-systemic-inflammatory-response-syndrome-in-the-icu(9afff7c3-7587-40bd-9dd1-e75e460d9c47).html
https://pure.amc.nl/en/publications/validation-of-a-host-response-assay-septicyte-lab-for-discriminating-sepsis-from-systemic-inflammatory-response-syndrome-in-the-icu(9afff7c3-7587-40bd-9dd1-e75e460d9c47).html
Autor:
Shaoyi Jiang, Tom Baehr-Jones, Michael Hochberg, James T. Kirk, Daniel M. Ratner, Norman D. Brault
Publikováno v:
Biosensors and Bioelectronics. 42:100-105
A widely acknowledged goal in personalized medicine is to radically reduce the costs of highly parallelized, small fluid volume, point-of-care and home-based diagnostics. Recently, there has been a surge of interest in using complementary metal-oxide
Autor:
James T. Kirk, Marc J. M. Bonten, Antony Rapisarda, Tom van der Poll, Mervyn Thomas, Brendon P. Scicluna, Leo McHugh, Richard Bruce Brandon, Olaf L. Cremer, Marcus J. Schultz, Jeffrey Lipman, Jeffrey J. Presneill, Thomas D. Yager, Lonneke A. van Vught, Peter M. C. Klein Klouwenberg, Deon J. Venter, A Sutherland, Therese Seldon, Roslyn A. Brandon
Publikováno v:
PLoS medicine, 12(12). Public Library of Science
PLoS Medicine, Vol 12, Iss 12, p e1001916 (2015)
PLoS Medicine
PLoS Medicine, 12(12), e1001916. Public Library of Science
PLoS Medicine, Vol 12, Iss 12, p e1001916 (2015)
PLoS Medicine
PLoS Medicine, 12(12), e1001916. Public Library of Science
Background: Systemic inflammation is a whole body reaction having an infection-positive (i.e., sepsis) or infection-negative origin. It is important to distinguish between these two etiologies early and accurately because this has significant therape
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1df1b69e8ea0e9d0a628471368d67d8
https://dspace.library.uu.nl/handle/1874/333500
https://dspace.library.uu.nl/handle/1874/333500
Publikováno v:
Journal of Biomedical Materials Research Part A. :106-113
The role(s) of T lymphocytes in the foreign body response has not been thoroughly elucidated. Lymphocytes are known to augment macrophage adhesion and fusion in vitro. Furthermore, T lymphocytes are a possible source of the cytokines, IL-4 and IL-13,