Zobrazeno 1 - 10
of 306
pro vyhledávání: '"James T Elder"'
Autor:
Susan Martin, Jessica Tyrrell, E Louise Thomas, Matthew J Bown, Andrew R Wood, Robin N Beaumont, Lam C Tsoi, Philip E Stuart, James T Elder, Philip Law, Richard Houlston, Christopher Kabrhel, Nikos Papadimitriou, Marc Gunter, Caroline Bull, Joshua A Bell, Emma E Vincent, Naveed Sattar, Malcolm G Dunlop, Ian PM Tomlinson, Sara Lindström, INVENT consortium, Jimmy D Bell, Timothy Frayling, Hanieh Yaghootkar
Publikováno v:
eLife, Vol 11 (2022)
Externí odkaz:
https://doaj.org/article/40b858df13344706935722cd933d8d45
Autor:
Susan Martin, Jessica Tyrrell, E Louise Thomas, Matthew J Bown, Andrew R Wood, Robin N Beaumont, Lam C Tsoi, Philip E Stuart, James T Elder, Philip Law, Richard Houlston, Christopher Kabrhel, Nikos Papadimitriou, Marc J Gunter, Caroline J Bull, Joshua A Bell, Emma E Vincent, Naveed Sattar, Malcolm G Dunlop, Ian PM Tomlinson, Sara Lindström, INVENT consortium, Jimmy D Bell, Timothy M Frayling, Hanieh Yaghootkar
Publikováno v:
eLife, Vol 11 (2022)
Background: Some individuals living with obesity may be relatively metabolically healthy, whilst others suffer from multiple conditions that may be linked to adverse metabolic effects or other factors. The extent to which the adverse metabolic compon
Externí odkaz:
https://doaj.org/article/6ad55c6d14b64beb84bf87baac62a5be
Autor:
Lam C. Tsoi, Philip E. Stuart, Chao Tian, Johann E. Gudjonsson, Sayantan Das, Matthew Zawistowski, Eva Ellinghaus, Jonathan N. Barker, Vinod Chandran, Nick Dand, Kristina Callis Duffin, Charlotta Enerbäck, Tõnu Esko, Andre Franke, Dafna D. Gladman, Per Hoffmann, Külli Kingo, Sulev Kõks, Gerald G. Krueger, Henry W. Lim, Andres Metspalu, Ulrich Mrowietz, Sören Mucha, Proton Rahman, Andre Reis, Trilokraj Tejasvi, Richard Trembath, John J. Voorhees, Stephan Weidinger, Michael Weichenthal, Xiaoquan Wen, Nicholas Eriksson, Hyun M. Kang, David A. Hinds, Rajan P. Nair, Gonçalo R. Abecasis, James T Elder
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-8 (2017)
Psoriasis is an immune-mediated skin disease with a complex genetic architecture. Here, Elder and colleagues identify 16 novel psoriasis susceptibility loci using GWAS meta-analysis with a combined effective sample size of over 39,000 individuals.
Externí odkaz:
https://doaj.org/article/f7c9d14db1d44c6a865877ade1d17933
Autor:
Ashley Budu-Aggrey, Ben Brumpton, Jess Tyrrell, Sarah Watkins, Ellen H Modalsli, Carlos Celis-Morales, Lyn D Ferguson, Gunnhild Åberge Vie, Tom Palmer, Lars G Fritsche, Mari Løset, Jonas Bille Nielsen, Wei Zhou, Lam C Tsoi, Andrew R Wood, Samuel E Jones, Robin Beaumont, Marit Saunes, Pål Richard Romundstad, Stefan Siebert, Iain B McInnes, James T Elder, George Davey Smith, Timothy M Frayling, Bjørn Olav Åsvold, Sara J Brown, Naveed Sattar, Lavinia Paternoster
Publikováno v:
PLoS Medicine, Vol 16, Iss 1, p e1002739 (2019)
BackgroundPsoriasis is a common inflammatory skin disease that has been reported to be associated with obesity. We aimed to investigate a possible causal relationship between body mass index (BMI) and psoriasis.Methods and findingsFollowing a review
Externí odkaz:
https://doaj.org/article/f74e86d2e0074e57ac87d4c412e76f84
Autor:
Bram P Prins, Ali Abbasi, Anson Wong, Ahmad Vaez, Ilja Nolte, Nora Franceschini, Philip E Stuart, Javier Guterriez Achury, Vanisha Mistry, Jonathan P Bradfield, Ana M Valdes, Jose Bras, Aleksey Shatunov, PAGE Consortium, International Stroke Genetics Consortium, Systemic Sclerosis consortium, Treat OA consortium, DIAGRAM Consortium, CARDIoGRAMplusC4D Consortium, ALS consortium, International Parkinson’s Disease Genomics Consortium, Autism Spectrum Disorder Working Group of the Psychiatric Genomics Consortium, CKDGen consortium, GERAD1 Consortium, International Consortium for Blood Pressure, Schizophrenia Working Group of the Psychiatric Genomics Consortium, Inflammation Working Group of the CHARGE Consortium, Chen Lu, Buhm Han, Soumya Raychaudhuri, Steve Bevan, Maureen D Mayes, Lam C Tsoi, Evangelos Evangelou, Rajan P Nair, Struan F A Grant, Constantin Polychronakos, Timothy R D Radstake, David A van Heel, Melanie L Dunstan, Nicholas W Wood, Ammar Al-Chalabi, Abbas Dehghan, Hakon Hakonarson, Hugh S Markus, James T Elder, Jo Knight, Dan E Arking, Timothy D Spector, Bobby P C Koeleman, Cornelia M van Duijn, Javier Martin, Andrew P Morris, Rinse K Weersma, Cisca Wijmenga, Patricia B Munroe, John R B Perry, Jennie G Pouget, Yalda Jamshidi, Harold Snieder, Behrooz Z Alizadeh
Publikováno v:
PLoS Medicine, Vol 13, Iss 6, p e1001976 (2016)
BackgroundC-reactive protein (CRP) is associated with immune, cardiometabolic, and psychiatric traits and diseases. Yet it is inconclusive whether these associations are causal.Methods and findingsWe performed Mendelian randomization (MR) analyses us
Externí odkaz:
https://doaj.org/article/832430b3898d44f4b83d958198e99cbf
Autor:
William R Swindell, Mrinal K Sarkar, Philip E Stuart, John J Voorhees, James T Elder, Andrew Johnston, Johann E Gudjonsson
Publikováno v:
Clinical and Translational Medicine, Vol 4, Iss 1, Pp n/a-n/a (2015)
Abstract BackgroundPsoriasis is a cytokine‐mediated skin disease that can be treated effectively with immunosuppressive biologic agents. These medications, however, are not equally effective in all patients and are poorly suited for treating mild p
Externí odkaz:
https://doaj.org/article/701228f45ce24c008a69346110a2e7f4
Autor:
William R Swindell, Andrew Johnston, Xianying Xing, John J Voorhees, James T Elder, Johann E Gudjonsson
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e79253 (2013)
Whole-genome expression profiling has been used to characterize molecular-level differences between psoriasis lesions and normal skin. Pathway analysis, however, is complicated by the fact that expression profiles have been derived from bulk skin bio
Externí odkaz:
https://doaj.org/article/153bf196dbb6472eaf1289346efeebb2
Autor:
William R Swindell, Xianying Xing, Philip E Stuart, Cynthia S Chen, Abhishek Aphale, Rajan P Nair, John J Voorhees, James T Elder, Andrew Johnston, Johann E Gudjonsson
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e34594 (2012)
The clinical features of psoriasis, characterized by sharply demarcated scaly erythematous plaques, are typically so distinctive that a diagnosis can easily be made on these grounds alone. However, there is great variability in treatment response bet
Externí odkaz:
https://doaj.org/article/c9c6ca80713f49babc4b79fdb00daf63
Autor:
William R Swindell, Andrew Johnston, Liou Sun, Xianying Xing, Gary J Fisher, Martha L Bulyk, James T Elder, Johann E Gudjonsson
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e33204 (2012)
Skin aging is associated with intrinsic processes that compromise the structure of the extracellular matrix while promoting loss of functional and regenerative capacity. These processes are accompanied by a large-scale shift in gene expression, but u
Externí odkaz:
https://doaj.org/article/dce52a4941c64ae7b5dc422e4747c04b
Autor:
Chris Cotsapas, Benjamin F Voight, Elizabeth Rossin, Kasper Lage, Benjamin M Neale, Chris Wallace, Gonçalo R Abecasis, Jeffrey C Barrett, Timothy Behrens, Judy Cho, Philip L De Jager, James T Elder, Robert R Graham, Peter Gregersen, Lars Klareskog, Katherine A Siminovitch, David A van Heel, Cisca Wijmenga, Jane Worthington, John A Todd, David A Hafler, Stephen S Rich, Mark J Daly, FOCiS Network of Consortia
Publikováno v:
PLoS Genetics, Vol 7, Iss 8, p e1002254 (2011)
Genome-wide association (GWA) studies have identified numerous, replicable, genetic associations between common single nucleotide polymorphisms (SNPs) and risk of common autoimmune and inflammatory (immune-mediated) diseases, some of which are shared
Externí odkaz:
https://doaj.org/article/42c5fc70902a4cdf9097cdf576794c8d