Zobrazeno 1 - 10
of 201
pro vyhledávání: '"James T, McKenna"'
Autor:
Eden B. Maness, Joshua A. Burk, James T. McKenna, Felipe L. Schiffino, Robert E. Strecker, John G. McCoy
Publikováno v:
Brain Research Bulletin, Vol 188, Iss , Pp 47-58 (2022)
Experimental evidence has implicated multiple neurotransmitter systems in either the direct or indirect modulation of cortical arousal and attention circuitry. In this review, we selectively focus on three such systems: 1) norepinephrine (NE)-contain
Externí odkaz:
https://doaj.org/article/aeb9f05350d84d94ad1baddd3902aa60
Autor:
David S. Uygun, Chun Yang, Elena R. Tilli, Fumi Katsuki, Erik L. Hodges, James T. McKenna, James M. McNally, Ritchie E. Brown, Radhika Basheer
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Uygun et al. show that deletion of GABAA receptors from the thalamic reticular nucleus using CRISPR gene editing in mice boosts the delta waves, indicating a role for GABAA receptors on thalamic reticular nucleus neurons in NREM sleep delta oscillati
Externí odkaz:
https://doaj.org/article/f103563cadb64548a47d87698d2e0166
Autor:
Chun Yang, Andrei Larin, James T. McKenna, Kenneth A. Jacobson, Stuart Winston, Robert E. Strecker, Anna Kalinchuk, Radhika Basheer, Ritchie E. Brown
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)
Abstract The functions of purinergic P2 receptors (P2Rs) for extracellular adenosine triphosphate (ATP) are poorly understood. Here, for the first time, we show that activation of P2Rs in an important arousal region, the basal forebrain (BF), promote
Externí odkaz:
https://doaj.org/article/7b3e1e1e253041a2bc951220bd9dc89a
Autor:
Felipe L. Schiffino, James M. McNally, Eden B. Maness, James T. McKenna, Ritchie E. Brown, Robert E. Strecker
Publikováno v:
Journal of Sleep Research.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2d2b44363d96ccb149d3920256cd94b7
https://doi.org/10.1111/jsr.13919
https://doi.org/10.1111/jsr.13919
Publikováno v:
AIMS Neuroscience, Vol 3, Iss 1, Pp 67-104 (2016)
Sleep is a complex physiological process that is regulated globally, regionally, and locally by both cellular and molecular mechanisms. It occurs to some extent in all animals, although sleep expression in lower animals may be co-extensive with rest.
Externí odkaz:
https://doaj.org/article/14d292d8d2464e11a8ea1946384c52a3
Autor:
Radhika Basheer, Stuart Winston, Fumi Katsuki, Marissa B Anderson-Chernishof, Ritchie E. Brown, James T. McKenna, James M. McNally, Chun Yang, Mackenzie C. Gamble, Abigail Hulverson, Thomas Bellio, John G. McCoy, Erik L. Hodges
Publikováno v:
Brain Struct Funct
The basal forebrain (BF) is involved in arousal, attention, and reward processing but the role of individual BF neuronal subtypes is still being uncovered. Glutamatergic neurons are the least well-understood of the three main BF neurotransmitter phen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02a16c7e0cae3b6ad746b493fabbfa36
https://doi.org/10.1007/s00429-021-02288-7
https://doi.org/10.1007/s00429-021-02288-7
Autor:
Tracy Murray-Stewart, Michael J. Gambello, Robert A. Casero, David Kapfhamer, James T. McKenna, Caroline Yoon
Publikováno v:
Hum Mol Genet
Tuberous sclerosis complex (TSC) is a rare autosomal dominant neurodevelopmental disorder characterized by variable expressivity. TSC results from inactivating variants within the TSC1 or TSC2 genes, leading to constitutive activation of mechanistic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fac4693c3bbb021a1e0c63c53d9a796
https://doi.org/10.1093/hmg/ddaa121
https://doi.org/10.1093/hmg/ddaa121
Autor:
David S, Uygun, Chun, Yang, Elena R, Tilli, Fumi, Katsuki, Erik L, Hodges, James T, McKenna, James M, McNally, Ritchie E, Brown, Radhika, Basheer
Publikováno v:
Nature communications. 13(1)
Identification of mechanisms which increase deep sleep could lead to novel treatments which promote the restorative effects of sleep. Here, we show that knockdown of the α3 GABA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::242d1666b51841162ff7d1fdb2084491
https://pubmed.ncbi.nlm.nih.gov/35473906
https://pubmed.ncbi.nlm.nih.gov/35473906
Autor:
Ritchie E. Brown, Fumi Katsuki, David S. Uygun, Chun Yang, Radhika Basheer, James T. McKenna, James M. McNally, Elena R. Tilli
Identification of mechanisms which increase deep sleep could lead to novel treatments which promote the restorative effects of sleep. Here, knockdown of the α3 GABAA-receptor subunit from parvalbumin neurons in the thalamic reticular nucleus using C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4484f8311b144394355c8aab530fbb9d
https://doi.org/10.1101/2020.12.15.422912
https://doi.org/10.1101/2020.12.15.422912
Autor:
Stuart Winston, Chun Yang, John G. McCoy, Radhika Basheer, Mackenzie C. Gamble, James T. McKenna, Marissa B Anderson-Chernishof, Ritchie E. Brown, James M. McNally, Thomas Bellio, Abigail Hulverson
The basal forebrain (BF) is involved in arousal, attention, and reward processing but the role of individual BF subtypes is still being uncovered. Glutamatergic neurons are the least well-understood of the three major BF neurotransmitter phenotypes.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4dd5a45ace294da02302069739fe1023
https://doi.org/10.1101/2020.06.17.157479
https://doi.org/10.1101/2020.06.17.157479