Zobrazeno 1 - 10 of 10 pro vyhledávání: '"James T, DeLigio"'
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Serine/Arginine–Rich Splicing Factor 3 Modulates the Alternative Splicing of Cytoplasmic Polyadenylation Element Binding Protein 2
Autor: Margaret A. Park, Charles E. Chalfant, Shaun C. Stevens, H. Patrick MacKnight, Keli K. Doe, Gina S. Nazario-Muñoz, James T. DeLigio
Publikováno v: Mol Cancer Res
Triple negative breast cancer (TNBC) has an unusually low 5-year survival rate linked to higher metastatic rates. Our laboratory recently delineated a role for the alternative RNA splicing (AS) of cytoplasmic polyadenylation element binding protein 2
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68589dc1c80d2ab2570c97893eb0c65b
https://doi.org/10.1158/1541-7786.mcr-18-1291
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4
The interaction of ceramide 1-phosphate with group IVA cytosolic phospholipase A
Autor: H Patrick, MacKnight, Daniel J, Stephenson, L Alexis, Hoeferlin, Savannah D, Benusa, James T, DeLigio, Kenneth D, Maus, Anika N, Ali, Jennifer S, Wayne, Margaret A, Park, Edward H, Hinchcliffe, Rhoderick E, Brown, John J, Ryan, Robert F, Diegelmann, Charles E, Chalfant
Publikováno v: Sci Signal
The sphingolipid ceramide-1-phosphate (C1P) directly binds to and activates group IVA cytosolic phospholipase A(2) (cPLA(2)α) to stimulate the production of eicosanoids. Because eicosanoids are important in wound healing, we examined the repair of s
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::281384980fcb33eb98f47ff4a9d4a642
https://pubmed.ncbi.nlm.nih.gov/31796632
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5
The interaction of ceramide 1-phosphate with group IVA cytosolic phospholipase A 2 coordinates acute wound healing and repair
Autor: Savannah D. Benusa, Edward H. Hinchcliffe, Anika N. Ali, Daniel J. Stephenson, Charles E. Chalfant, H. Patrick MacKnight, L. Alexis Hoeferlin, Robert F. Diegelmann, Rhoderick E. Brown, Kenneth Maus, James T. DeLigio, Jennifer S. Wayne, John J. Ryan, Margaret A. Park
Publikováno v: Science Signaling. 12
The sphingolipid ceramide 1-phosphate (C1P) directly binds to and activates group IVA cytosolic phospholipase A2 (cPLA2α) to stimulate the production of eicosanoids. Because eicosanoids are important in wound healing, we examined the repair of skin
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d487ca57b3c8085a17b69fb55ec1db37
https://doi.org/10.1126/scisignal.aav5918
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6
Splice variants of cytosolic polyadenylation element–binding protein 2 (CPEB2) differentially regulate pathways linked to cancer metastasis
Autor: Margaret A. Park, Grace Lin, James T. DeLigio, Charles E. Chalfant
Publikováno v: Journal of Biological Chemistry. 292:17909-17918
The translational regulator cytosolic polyadenylation element–binding protein 2 (CPEB2) has two isoforms, CPEB2A and CPEB2B, derived by alternative splicing of RNA into a mature form that either includes or excludes exon 4. Previously, we reported
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5714fae8c23326aee1e97cf7a41ec8da
https://doi.org/10.1074/jbc.m117.810127
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7
Regulatory T Cells Support Breast Cancer Progression by Opposing IFN-γ-Dependent Functional Reprogramming of Myeloid Cells
Autor: Amy L. Olex, Steven Murdock, Paula D. Bos, Mikhail G. Dozmorov, Nicholas M. Clark, Comfort C Effi, Leandro M. Martinez, James T. DeLigio
Publikováno v: Cell Rep
Regulatory T (Treg) cell infiltration of solid tumors often correlates with poor prognosis, but their tumor-suppressive function lacks mechanistic understanding. Through a combination of transgenic mice, cell fate mapping, adoptive transfer, and co-i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11b13b76ad1ddfe322ebcc3cb34d58e0
https://doi.org/10.1016/j.celrep.2020.108482
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8
Intrinsic Resistance to Cixutumumab Is Conferred by Distinct Isoforms of the Insulin Receptor
Autor: David Surguladze, Dale L. Ludwig, Ying Wang, Gregory P. Donoho, Nina Zanella, Ruslan D. Novosiadly, Christopher B. Damoci, Malcolm A. Smith, Colleen A. Burns, James T. DeLigio, Marie Prewett, Heinz H. Fiebig, Michael Amatulli, Peter J. Houghton, Amelie Forest
Publikováno v: Molecular Cancer Research. 13:1615-1626
Despite a recent shift away from anti–insulin-like growth factor I receptor (IGF-IR) therapy, this target has been identified as a key player in the resistance mechanisms to various conventional and targeted agents, emphasizing its value as a thera
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4b69b3f29f01f65c076e6f007937ac0
https://doi.org/10.1158/1541-7786.mcr-15-0279
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9
Micro-RNA149 confers taxane resistance to malignant mesothelioma cells via regulation of P-glycoprotein expression
Autor: Dale B. Bosco, Rachael Kenworthy, Diego A. R. Zorio, James T. DeLigio
Publikováno v: Cancer biologytherapy. 19(3)
Multidrug resistance (MDR) represents a major hindrance to the efficacy of cancer chemotherapeutics. While surgical resection, radiation, and chemotherapy can be used to reduce tumor size, the subsequent appearance of drug resistant cells is a freque
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f90b7744e06b7bcd9ffe539c1795c2a
https://pubmed.ncbi.nlm.nih.gov/29261027
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