An Emerging Screening Method for Interrogating Human Brain Function: Tutorial

Autor: Gustavo Sudre, Anto I Bagić, James T Becker, John P Ford

Publikováno v: JMIR Formative Research, Vol 7, p e37269 (2023)

Cognitive decline can be observed due to a myriad of causes. Clinicians would benefit from a noninvasive quantitative tool to screen and monitor brain function based on direct measures of neural features. In this study, we used neuroimaging data from

Externí odkaz: https://doaj.org/article/73712a7f5f3c463d88ceb1b25882f184

Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults

Autor: Edith Hofer, Gennady V. Roshchupkin, Hieab H. H. Adams, Maria J. Knol, Honghuang Lin, Shuo Li, Habil Zare, Shahzad Ahmad, Nicola J. Armstrong, Claudia L. Satizabal, Manon Bernard, Joshua C. Bis, Nathan A. Gillespie, Michelle Luciano, Aniket Mishra, Markus Scholz, Alexander Teumer, Rui Xia, Xueqiu Jian, Thomas H. Mosley, Yasaman Saba, Lukas Pirpamer, Stephan Seiler, James T. Becker, Owen Carmichael, Jerome I. Rotter, Bruce M. Psaty, Oscar L. Lopez, Najaf Amin, Sven J. van der Lee, Qiong Yang, Jayandra J. Himali, Pauline Maillard, Alexa S. Beiser, Charles DeCarli, Sherif Karama, Lindsay Lewis, Mat Harris, Mark E. Bastin, Ian J. Deary, A. Veronica Witte, Frauke Beyer, Markus Loeffler, Karen A. Mather, Peter R. Schofield, Anbupalam Thalamuthu, John B. Kwok, Margaret J. Wright, David Ames, Julian Trollor, Jiyang Jiang, Henry Brodaty, Wei Wen, Meike W. Vernooij, Albert Hofman, André G. Uitterlinden, Wiro J. Niessen, Katharina Wittfeld, Robin Bülow, Uwe Völker, Zdenka Pausova, G. Bruce Pike, Sophie Maingault, Fabrice Crivello, Christophe Tzourio, Philippe Amouyel, Bernard Mazoyer, Michael C. Neale, Carol E. Franz, Michael J. Lyons, Matthew S. Panizzon, Ole A. Andreassen, Anders M. Dale, Mark Logue, Katrina L. Grasby, Neda Jahanshad, Jodie N. Painter, Lucía Colodro-Conde, Janita Bralten, Derrek P. Hibar, Penelope A. Lind, Fabrizio Pizzagalli, Jason L. Stein, Paul M. Thompson, Sarah E. Medland, ENIGMA consortium, Perminder S. Sachdev, William S. Kremen, Joanna M. Wardlaw, Arno Villringer, Cornelia M. van Duijn, Hans J. Grabe, William T. Longstreth, Myriam Fornage, Tomas Paus, Stephanie Debette, M. Arfan Ikram, Helena Schmidt, Reinhold Schmidt, Sudha Seshadri

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)

Cortex morphology varies with age, cognitive function, and in neurological and psychiatric diseases. Here the authors report 160 genome-wide significant associations with thickness, surface area and volume of the total cortex and 34 cortical regions

Externí odkaz: https://doaj.org/article/5d16e85f224b486f9cfab04f0d940bed

Connectomics in Brain Aging and Dementia – The Background and Design of a Study of a Connectome Related to Human Disease

Autor: Ann D. Cohen, Ricardo Bruña, Yue-Fang Chang, Yu Cheng, Jack Doman, Ted Huppert, Tae Kim, Fernando Maestu, Rebecca E. Roush, Beth E. Snitz, James T. Becker

Publikováno v: Frontiers in Aging Neuroscience, Vol 13 (2021)

The natural history of Alzheimer’s Disease (AD) includes significant alterations in the human connectome, and this disconnection results in the dementia of AD. The organizing principle of our research project is the idea that the expression of cogn

Externí odkaz: https://doaj.org/article/bf9ac7e7bf504f21afe889faebe63574

Cardiac-induced cerebral pulsatility, brain structure, and cognition in middle and older-aged adults

Autor: Tae Kim, Sang-Young Kim, Vikas Agarwal, Annie Cohen, Rebecca Roush, Yue-Fang Chang, Yu Cheng, Beth Snitz, Theodore J Huppert, Anto Bagic, M. Ilyas Kamboh, Jack Doman, James T. Becker

Publikováno v: NeuroImage, Vol 233, Iss , Pp 117956- (2021)

Changes of cardiac-induced regional pulsatility can be associated with specific regions of brain volumetric changes, and these are related with cognitive alterations. Thus, mapping of cardiac pulsatility over the entire brain can be helpful to assess

Externí odkaz: https://doaj.org/article/41d9d1bcb9834cad9782d89061735474

Dynamic impairment classification through arrayed comparisons

Autor: Zheng Wang, Zi Wang, Lingyun Lyu, Yu Cheng, Eric C. Seaberg, Samantha A. Molsberry, Ann Ragin, James T. Becker

Publikováno v: Statistics in Medicine. 42:52-67

The multivariate normative comparison (MNC) method has been used for identifying cognitive impairment. When participants' cognitive brain domains are evaluated regularly, the longitudinal MNC (LMNC) has been introduced to correct for the intercorrela

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c271b9ffed2c9258da48483f31078cd
https://doi.org/10.1002/sim.9601