Zobrazeno 1 - 10
of 17
pro vyhledávání: '"James Surapisitchat"'
Autor:
Simon C. Johnson, Charles E. Alpers, James Surapisitchat, Theodor K. Bammler, Jocelyn H. Wright, Renay L. Bauer, Richard P. Beyer, Jean S. Campbell, Debra G. Gilbertson, Melissa M. Johnson, Nelson Fausto, Brian J. Hayes, Masami Shimizu-Albergine, Kimberly J. Riehle, Matthew M. Yeh, Kelly L. Hudkins
Publikováno v:
International Journal of Cancer. 134:778-788
Cirrhosis is the primary risk factor for the development of hepatocellular carcinoma (HCC), yet the mechanisms by which cirrhosis predisposes to carcinogenesis are poorly understood. Using a mouse model that recapitulates many aspects of the pathophy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::62c3b9455d0e29719c5006f97017f9ed
https://doi.org/10.1002/ijc.28421
https://doi.org/10.1002/ijc.28421
Publikováno v:
Annals of the New York Academy of Sciences. 947:93-111
Atherosclerosis preferentially occurs in areas of turbulent flow and low fluid shear stress, whereas laminar flow and high shear stress are atheroprotective. Inflammatory cytokines, such as tumor necrosis factor-alpha (TNF), have been shown to stimul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e6cf8f6b75344bb7cc088c003249e99
https://doi.org/10.1111/j.1749-6632.2001.tb03932.x
https://doi.org/10.1111/j.1749-6632.2001.tb03932.x
Autor:
Gwen Garin, Masanori Yoshizumi, Yoji Taba, Jun Ichi Abe, Kanchana Natarajan, Lingli Li, James Surapisitchat, Caspar Tai, Bradford C. Berk, Chen Yan, Revati J. Tatake, Ed Leung
Publikováno v:
Biochemical and Biophysical Research Communications. 370:159-163
Steady laminar blood flow protects vessels from atherosclerosis. We showed that flow decreased tumor necrosis factor-α (TNF)-mediated VCAM1 expression in endothelial cells (EC) by inhibiting JNK. Here, we determined the relative roles of MEK1, MEK5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cd05c2ebed0a0cc7721784f88011c17
https://doi.org/10.1016/j.bbrc.2008.03.051
https://doi.org/10.1016/j.bbrc.2008.03.051
Publikováno v:
Circulation Research. 101:811-818
Endothelial barrier dysfunction leading to increased permeability and vascular leakage is an underlying cause of several pathological conditions, including edema and sepsis. Whereas cAMP has been shown to decrease endothelial permeability, the role o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c24517b0a823a5a8d992ffca2986ce1
https://doi.org/10.1161/circresaha.107.154229
https://doi.org/10.1161/circresaha.107.154229
Autor:
James Surapisitchat, Bradford C. Berk, Masashi Akaike, Jun Ichi Abe, Hisaaki Kawakatsu, Masanori Yoshizumi, Nicole Lerner-Marmarosh, Wenyi Che, Chen Yan, Bo Ding, Qunhua Huang
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 23:1775-1781
Objectives— Atherosclerosis preferentially occurs in areas of turbulent flow, whereas laminar flow is atheroprotective. Inflammatory cytokines have been shown to stimulate adhesion molecule expression in endothelial cells that may promote atheroscl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29490281dcbf6b5b43ad45dcfad1ad0d
https://doi.org/10.1161/01.atv.0000094432.98445.36
https://doi.org/10.1161/01.atv.0000094432.98445.36
Publikováno v:
Scopus-Elsevier
The inflammatory cytokine TNF-alpha stimulates several presumed pro-atherogenic signaling events in endothelial cells (ECs), including activation of c-Jun NH(2)-terminal kinase (JNK) and induction of E-selectin. Here, we show that apoptosis signal-re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::417a795169bfe6e5904a07a084d45dc2
https://doi.org/10.1172/jci11947
https://doi.org/10.1172/jci11947
Autor:
Rebecca R. Laposa, Kim S. Sugamori, Stephen C. Strom, Maryam Niapour, Denis M. Grant, James Surapisitchat, Rachel F. Tyndale, Shinichiro Ogawa, Gordon Keller, Carl Virtanen, Ewa Hoffmann, Bin Zhao, Shuang Wang, Laura Tamblyn, Mina Ogawa, Chantal Guillemette
Human pluripotent stem cells (hPSCs) represent a novel source of hepatocytes for drug metabolism studies and cell-based therapy for the treatment of liver diseases. These applications are, however, dependent on the ability to generate mature metaboli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cbb6b4df84e055a29dac639209389ba
https://europepmc.org/articles/PMC4074277/
https://europepmc.org/articles/PMC4074277/
Autor:
Jocelyn H, Wright, Melissa M, Johnson, Masami, Shimizu-Albergine, Renay L, Bauer, Brian J, Hayes, James, Surapisitchat, Kelly L, Hudkins, Kimberly J, Riehle, Simon C, Johnson, Matthew M, Yeh, Theodor K, Bammler, Richard P, Beyer, Debra G, Gilbertson, Charles E, Alpers, Nelson, Fausto, Jean S, Campbell
Publikováno v:
International journal of cancer. 134(4)
Cirrhosis is the primary risk factor for the development of hepatocellular carcinoma (HCC), yet the mechanisms by which cirrhosis predisposes to carcinogenesis are poorly understood. Using a mouse model that recapitulates many aspects of the pathophy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c7c35e1083a9a53b3041a85b7798c2fa
https://pubmed.ncbi.nlm.nih.gov/23929039
https://pubmed.ncbi.nlm.nih.gov/23929039
Autor:
Joseph A. Beavo, James Surapisitchat
Publikováno v:
Phosphodiesterases as Drug Targets ISBN: 9783642179686
The endothelium plays an important role in maintaining normal vascular function. Endothelial barrier dysfunction leading to increased permeability and vascular leakage is associated with several pathological conditions such as edema and sepsis. Thus,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3788aaa50d0d907023f6436db3f7760d
https://pubmed.ncbi.nlm.nih.gov/21695641
https://pubmed.ncbi.nlm.nih.gov/21695641
Autor:
Joseph A. Beavo, James Surapisitchat
Publisher Summary There are 11 known phosphodiesterase (PDE) gene families, each with their own distinct characteristics. The phosphodiesterases share the same organizational structure. Each protein has an N-terminal domain that confers regulatory pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c6922437ea079f46b12f7194a146987f
https://doi.org/10.1016/b978-0-12-374145-5.00173-x
https://doi.org/10.1016/b978-0-12-374145-5.00173-x