Zobrazeno 1 - 6
of 6
pro vyhledávání: '"James Stables"'
Autor:
James O. McNamara, Greg C. Rigdon, Grant Andrew Mcnaughton-Smith, Stephen Werness, Rosemarie Roeloffs, James Stables, Christopher Crean, Neil Ghodadra, Alan D. Wickenden
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 326:818-828
Openers or activators of neuronal KCNQ2/Q3 potassium channels decrease neuronal excitability and may provide benefit in the treatment of disorders of neuronal excitability such as epilepsy. In the present study, we evaluate the effects of ICA-27243 [
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd9a79df4148149c3a089dafe0ea650a
https://doi.org/10.1124/jpet.108.137794
https://doi.org/10.1124/jpet.108.137794
Autor:
Perumal Yogeeswari, Ramkumar Kavya, Jegadeesan Vaigunda Ragavendran, Yarravarapu Nageswari, Dharmarajan Sriram, James Stables, Kaliappan Vanitha, Narayanan Sreevatsan
Publikováno v:
Journal of Medicinal Chemistry. 50:2459-2467
Antiepileptic drugs are often utilized in the treatment of neuropathic pain. The present study aims at the design and synthesis of newer gamma-aminobutyric acid (GABA) derivatives with the combination of aryl semicarbazone and the GABA pharmacophores
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56b295ec2fda08c34014efd6ad31fb09
https://doi.org/10.1021/jm061431g
https://doi.org/10.1021/jm061431g
Autor:
Robert J. Parker, Bryan A. Roecklein, James Stables, Henry Mortko, Neil R. Hartman, John M. Strong, Harvey J Kupferberg
Publikováno v:
Chemical Research in Toxicology. 18:1842-1848
Evidence has been presented suggesting that a reactive metabolite, 2-phenylpropenal (ATPAL), may be responsible for the toxicities observed during therapy with the antiepileptic drug felbamate (FBM). Formation of ATPAL from its unstable immediate pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c39341383c54d9bddfeea2b6b281f1ed
https://doi.org/10.1021/tx050130r
https://doi.org/10.1021/tx050130r
Autor:
Ramkumar Kavya, Jayakar Selwyn Samuel, Rathinasabapathy Thirumurugan, Perumal Yogeeswari, Dharmarajan Sriram, James Stables
Publikováno v:
European Journal of Medicinal Chemistry. 39:729-734
A series of 3-chloro-2-methylphenyl substituted semicarbazones (3-33) was synthesized and evaluated for anticonvulsant and CNS activities. After intraperitoneal injection to mice or rats, the semicarbazone derivatives were examined in the maximal ele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c617ce045237bd0d9b239e08c59be7b
https://doi.org/10.1016/j.ejmech.2004.03.008
https://doi.org/10.1016/j.ejmech.2004.03.008
Autor:
Aristea S, Galanopoulou, Paul S, Buckmaster, Kevin J, Staley, Solomon L, Moshé, Emilio, Perucca, Jerome, Engel, Wolfgang, Löscher, Jeffrey L, Noebels, Asla, Pitkänen, James, Stables, H Steve, White, Terence J, O'Brien, Michele, Simonato, Libor, Velisek
Publikováno v:
Epilepsia. 53(3)
Preclinical research has facilitated the discovery of valuable drugs for the symptomatic treatment of epilepsy. Yet, despite these therapies, seizures are not adequately controlled in a third of all affected individuals, and comorbidities still impos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f1ac79876385d8c2f02606b5e7f6f2ff
https://pubmed.ncbi.nlm.nih.gov/22292566
https://pubmed.ncbi.nlm.nih.gov/22292566
Autor:
Rathinasabapathy Thirumurugan, Roheeth Kumar Pavana, Perumal Yogeeswari, James Stables, Dharmarajan Sriram, Kannan Sudhan, Jegadeesan Vaigunda Raghavendran
Publikováno v:
Journal of medicinal chemistry. 48(20)
Epilepsy is the most common primary neurological disorder known. In the past decade, various aryl semicarbazones have been designed that were structurally dissimilar from many common anticonvulsants containing the dicarboximide function (CONRCO), whi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d35fcad5eb17c96155a328cc233c83a7
https://pubmed.ncbi.nlm.nih.gov/16190747
https://pubmed.ncbi.nlm.nih.gov/16190747