Zobrazeno 1 - 7
of 7
pro vyhledávání: '"James Spoonamore"'
Autor:
Kristin J. Adolfsen, Isolde Callihan, Catherine E. Monahan, Per Jr. Greisen, James Spoonamore, Munira Momin, Lauren E. Fitch, Mary Joan Castillo, Lindong Weng, Lauren Renaud, Carl J. Weile, Jay H. Konieczka, Teodelinda Mirabella, Andres Abin-Fuentes, Adam G. Lawrence, Vincent M. Isabella
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
PKU patients have elevated phenylalanine levels which can result in neurological impairment. Here the authors utilize biosensor-based ultra-high-throughput screening to optimize PAL activity in a synthetic biotic platform for improved in vivo perform
Externí odkaz:
https://doaj.org/article/026a2581af754d8aa8526f2be41ac1f4
Autor:
Kritika Hanamshet, Tomasz Skorski, Mikir Patel, Nadish Goyal, Alexander V. Mazin, Olga M. Mazina, James Spoonamore, Shailesh Metkar, Katherine J. Sullivan, Kyle A. Emmitte, Charles X. Wang, Simon Cocklin, W. Frank An, Fei Huang
Publikováno v:
Nucleic Acids Research
RAD52 is a member of the homologous recombination (HR) pathway that is important for maintenance of genome integrity. While single RAD52 mutations show no significant phenotype in mammals, their combination with mutations in genes that cause heredita
Autor:
Whitney Silkworth, Michel Weïwer, Stuart L. Schreiber, Andrew M. Stern, James Spoonamore, Christina Scherer, Sivaraman Dandapani, Kristina Masson, Jingqiang Wei, Nathan T. Ross, Michelle Palmer, Boris Guichard, Benito Munoz
Publikováno v:
ACS Medicinal Chemistry Letters
The KRAS oncogene is found in up to 30% of all human tumors. In 2009, RNAi experiments revealed that lowering mRNA levels of a transcript encoding the serine/threonine kinase STK33 was selectively toxic to KRAS-dependent cancer cell lines, suggesting
Autor:
Karen K. Takane, Stuart L. Schreiber, Paul A. Clemons, Alykhan F. Shamji, James Spoonamore, Nathalie Fiaschi-Taesch, Dina Fomina-Yadlin, Thomas P. Hasaka, Deepika Walpita, Andrew F. Stewart, Amedeo Vetere, Bridget K. Wagner
Publikováno v:
SLAS Discovery. 17:509-518
A small-molecule inducer of beta-cell proliferation in human islets represents a potential regeneration strategy for treating type 1 diabetes. However, the lack of suitable human beta cell lines makes such a discovery a challenge. Here, we adapted an
Autor:
James Spoonamore, Jack T. Rogers
Publikováno v:
Alzheimer's & Dementia. 9
The histone acetyltransferase Rtt109 is the sole enzyme responsible for acetylation of histone H3 lysine 56 (H3K56) in fungal organisms. Loss of Rtt109 renders fungal cells extremely sensitive to genotoxic agents, and prevents pathogenesis in several
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63d4a224e2f62a766adb75daca012e05
https://europepmc.org/articles/PMC3654155/
https://europepmc.org/articles/PMC3654155/
Autor:
L.Charlie Chen, Kenneth F. Wertman, James Spoonamore, Anna Robinson, Sydney Wilson, David S. Thorpe, Alan Binnie, Martha Ackerman-Berrier, Shelly Wade, Stefan Walle, Helen Yeoman, Qinyuan (Quincey) Wu, A.W. Edith Chan, David Rodwell
Publikováno v:
Biochemical and biophysical research communications. 266(1)
Living systems are mainly composed and regulated by compounds in four biochemical classes and their polymers-nucleotides, carbohydrates, lipids, and amino acids. Early combinatorial chemistry libraries consisted of peptides. The present report descri