Zobrazeno 1 - 4
of 4
pro vyhledávání: '"James Smythies"'
Autor:
Steffen Grampp, Virginia Schmid, Rafik Salama, Victoria Lauer, Franziska Kranz, James L Platt, James Smythies, Hani Choudhry, Margarete Goppelt-Struebe, Peter J Ratcliffe, David R Mole, Johannes Schödel
Publikováno v:
PLoS Genetics, Vol 13, Iss 7, p e1006872 (2017)
Un-physiological activation of hypoxia inducible factor (HIF) is an early event in most renal cell cancers (RCC) following inactivation of the von Hippel-Lindau tumor suppressor. Despite intense study, how this impinges on cancer development is incom
Externí odkaz:
https://doaj.org/article/6b09644ca2b74a97a5428c0dec856c48
Autor:
James L, Platt, Rafik, Salama, James, Smythies, Hani, Choudhry, James Oj, Davies, Jim R, Hughes, Peter J, Ratcliffe, David R, Mole
Publikováno v:
EMBO Reports
Hypoxia‐inducible factor (HIF) directs an extensive transcriptional cascade that transduces numerous adaptive responses to hypoxia. Pan‐genomic analyses, using chromatin immunoprecipitation and transcript profiling, have revealed large numbers of
Autor:
Renato V. Iozzo, Atul Goyal, Chiara Poluzzi, Adam Shellard, James Smythies, Chris D. Willis, Thomas Neill
Publikováno v:
Journal of Biological Chemistry. 287:43543-43556
Endorepellin, the angiostatic C-terminal domain of the heparan sulfate proteoglycan perlecan, inhibits angiogenesis by simultaneously binding to the α2β1 integrin and the vascular endothelial growth factor (VEGF) receptor 2 (VEGFR2) on endothelial
Autor:
Renato V. Iozzo, Atul Goyal, Chiara Poluzzi, James Smythies, Thomas Neill, Simone Buraschi, Rick T. Owens, Liliana Schaefer, Annabel Torres
Publikováno v:
Proceedings of the National Academy of Sciences. 110
Soluble decorin affects the biology of several receptor tyrosine kinases by triggering receptor internalization and degradation. We found that decorin induced paternally expressed gene 3 (Peg3), an imprinted tumor suppressor gene, and that Peg3 reloc