Zobrazeno 1 - 10
of 16
pro vyhledávání: '"James Smothers"'
Autor:
Junping Jing, Laura Bover, C Ian Mockridge, Kerry L Cox, Mark S Cragg, Tatyana Inzhelevskaya, Chris A Penfold, Vikki English, Jane E Willoughby, Hong Shi, Peter J Morley, Heather Jackson, Roopa Srinivasan, Tom Murray, Axel Hoos, Paul Bojczuk, James Smothers, Niranjan Yanamandra, Lang Dou, Sabyasachi Bhattacharya, Laura Seestaller-Wehr, David Kilian, Kui S Voo, Mel John, Heather Niederer, Andrew J Shepherd, Laura Hook, Stephanie Hopley, Sara J Brett, Christopher Hopson, Elaine Paul, Stephen L Martin
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 7 (2024)
Background OX40 has been widely studied as a target for immunotherapy with agonist antibodies taken forward into clinical trials for cancer where they are yet to show substantial efficacy. Here, we investigated potential mechanisms of action of anti-
Externí odkaz:
https://doaj.org/article/1d4a1e220c0f453894379600a08cb4a4
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
In recent years, a set of immune receptors that interact with members of the nectin/nectin-like (necl) family has garnered significant attention as possible points of manipulation in cancer. Central to this axis, CD226, TIGIT, and CD96 represent liga
Externí odkaz:
https://doaj.org/article/de4cbba0e3fd4f49b752e681262c16cf
Autor:
Jeremy Waight, Katie Vowell, Michael Conner, Florence Perrin, Paul Bojczuk, Kenneth Hance, Iris Roth, Christine Donahue, James Smothers
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
Externí odkaz:
https://doaj.org/article/79d6b0e3975b439185666307700d067b
Autor:
Patrick Hwu, Niranjan Yanamandra, Elaine M. Paul, Roopa Srinivasan, James Smothers, Axel Hoos, Michael A. Davies, Hussein A. Tawbi, Gregory Lizee, Jian Wang, Sara Elizabeth Leahey, Rina M. Mbofung, Kui S. Voo, Heather L. Jackson, Yuan Chen, Jodi A. McKenzie, Brenda Melendez, Chunyu Xu, Leila J. Williams, Weiyi Peng
The cytokine changes in mice receiving PI3K inhibition in combination with anti-OX40 treatment.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61f6039acfa1d8709a210d4ff0939de3
https://doi.org/10.1158/1078-0432.22472204.v1
https://doi.org/10.1158/1078-0432.22472204.v1
Autor:
Axel Hoos, James Smothers, Shu Zhang, Junping Jing, Lyuben Tsvetkov, Chris Hopson, Shu-Yun Zhang, Laura Seestaller-Wehr, Jingsong Yang, Tianqian Zhang, Sapna Yadavilli, Hong Shi, Stephen Eastman, Patrick A. Mayes, Li Liu
Supplementary Materials and Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c132032d92e87d5e6b477ea82f956e1
https://doi.org/10.1158/1078-0432.22461912
https://doi.org/10.1158/1078-0432.22461912
Autor:
Axel Hoos, James Smothers, Shu Zhang, Junping Jing, Lyuben Tsvetkov, Chris Hopson, Shu-Yun Zhang, Laura Seestaller-Wehr, Jingsong Yang, Tianqian Zhang, Sapna Yadavilli, Hong Shi, Stephen Eastman, Patrick A. Mayes, Li Liu
Purpose: To assess the immunologic effects of dabrafenib and trametinib in vitro and to test whether trametinib potentiates or antagonizes the activity of immunomodulatory antibodies in vivo.Experimental Design: Immune effects of dabrafenib and trame
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::661aaed347926a54cf4ec666b3845e7f
https://doi.org/10.1158/1078-0432.c.6524868.v1
https://doi.org/10.1158/1078-0432.c.6524868.v1
Autor:
Patrick Hwu, Niranjan Yanamandra, Elaine M. Paul, Roopa Srinivasan, James Smothers, Axel Hoos, Michael A. Davies, Hussein A. Tawbi, Gregory Lizee, Jian Wang, Sara Elizabeth Leahey, Rina M. Mbofung, Kui S. Voo, Heather L. Jackson, Yuan Chen, Jodi A. McKenzie, Brenda Melendez, Chunyu Xu, Leila J. Williams, Weiyi Peng
Supplementary Figure legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fed6dfda111375a3bc5f8f7a1df7f23
https://doi.org/10.1158/1078-0432.22472201.v1
https://doi.org/10.1158/1078-0432.22472201.v1
Autor:
Patrick Hwu, Niranjan Yanamandra, Elaine M. Paul, Roopa Srinivasan, James Smothers, Axel Hoos, Michael A. Davies, Hussein A. Tawbi, Gregory Lizee, Jian Wang, Sara Elizabeth Leahey, Rina M. Mbofung, Kui S. Voo, Heather L. Jackson, Yuan Chen, Jodi A. McKenzie, Brenda Melendez, Chunyu Xu, Leila J. Williams, Weiyi Peng
Purpose:OX40 agonist–based combinations are emerging as a novel avenue to improve the effectiveness of cancer immunotherapy. To better guide its clinical development, we characterized the role of the OX40 pathway in tumor-reactive immune cells. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21ac271984f7d9259de1b307571c8647
https://doi.org/10.1158/1078-0432.c.6528155.v1
https://doi.org/10.1158/1078-0432.c.6528155.v1
Autor:
Axel Hoos, James Smothers, Shu Zhang, Junping Jing, Lyuben Tsvetkov, Chris Hopson, Shu-Yun Zhang, Laura Seestaller-Wehr, Jingsong Yang, Tianqian Zhang, Sapna Yadavilli, Hong Shi, Stephen Eastman, Patrick A. Mayes, Li Liu
Supplementary tables S1-S6. Tumor gene expression data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49df5c367a4323164d8cf2bdc745816b
https://doi.org/10.1158/1078-0432.22461903.v1
https://doi.org/10.1158/1078-0432.22461903.v1
Autor:
Annah S Rolig, Elizabeth R Sturgill, Courtney Mick, Daniel Rose, Johanna Kaufmann, Niranjan Yanamandra, Sue Griffin, James Smothers, William L Redmond
Publikováno v:
The Journal of Immunology. 208:119.12-119.12
Only a subset of patients durable clinical responses to aPD-1 and/or aCTLA-4 immunotherapies, thus, developing new therapeutic agents to increase the proportion of responding patients is a priority. Combining aPD-1 with aLAG-3 has shown promising res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bcee3e6347319384a9a4bcee7da3cbfc
https://doi.org/10.4049/jimmunol.208.supp.119.12
https://doi.org/10.4049/jimmunol.208.supp.119.12