Zobrazeno 1 - 10
of 14
pro vyhledávání: '"James Smalley"'
Autor:
Shiuhang Yip, Emily Luk, Anwar Murtaza, Yong Zhang, Michael A. Poss, Louis J. Lombardo, Nimmi Raghavan, Zheng Yang, James Kempson, Audris Huang, David R. Tortolani, Jesse Swanson, Xiaoping Hou, Joseph Pawluczyk, James Smalley, Honghe Wan, Karen E. Parrish, Robert M. Borzilleri, Ashok V. Purandare, Karen Augustine-Rauch, Andrew F. Donnell
Publikováno v:
Journal of Medicinal Chemistry. 64:15787-15798
Inhibition of TGFβ signaling in concert with a checkpoint blockade has been shown to provide improved and durable antitumor immune response in mouse models. However, on-target adverse cardiovascular effects have limited the clinical use of TGFβ rec
Autor:
Emily Luk, Karen E. Parrish, Yue-Zhong Shu, Anwar Murtaza, Yongnian Sun, Jinwen Huang, Robert M. Borzilleri, Paul Stetsko, Mary Ellen Cvijic, Jonathan G. Pabalan, Lihong Cheng, Zheng Yang, Jesse Swanson, James R. Burke, Tatyana Zvyaga, James Smalley, Karen A. Augustine
Publikováno v:
Biopharmaceutics & Drug Disposition. 42:137-149
Transforming growth factor beta (TGF-β) is a pleiotropic cytokine that has a wide array of biological effects. For decades, tumor biology implicated TGF-β as an attractive therapeutic target due to its immunosuppressive effects. Toward this end, mu
Autor:
R. Marcus Fancher, Elizabeth A. Dierks, Jamus MacGuire, Chiuwa E. Luk, James Smalley, Kimberly A. Foster, Evan B. Janovitz, Qin Sun, Hong Cai, Maxine Fox
Publikováno v:
Pharmacology Research & Perspectives
In this study, we describe a novel approach for collecting bile from dogs and cynomolgus monkeys for metabolite profiling, ultrasound‐guided cholecystocentesis (UCC). Sampling bile by UCC twice within 24 hours was well tolerated by dogs and monkeys
Autor:
William C. Stevens, John A. Lupisella, Venkataiah Bollu, Richard Martin, Denise Grimm, Rangaraj Narayanan, Max H. Nanao, Ruth R. Wexler, Raju Mohan, Xiaoping Hou, Meriah Neissel Valente, Brant Clayton Boren, Grace Yan, James Smalley, Brett B. Busch, Jacek Ostrowski, Paul G. Sleph, Yinong Xie, Barry Brock, Ira G. Schulman, A. David Rodrigues, Artur Plonowski, Glenn H. Cantor, Michael Charles Nyman, Huiping Zhang, Lam Nguyen, Ellen K. Kick, Todd G. Kirchgessner, Kamelia Behnia
Publikováno v:
ACS medicinal chemistry letters. 7(12)
Introducing a uniquely substituted phenyl sulfone into a series of biphenyl imidazole liver X receptor (LXR) agonists afforded a dramatic potency improvement for induction of ATP binding cassette transporters, ABCA1 and ABCG1, in human whole blood. T
Publikováno v:
Rapid Communications in Mass Spectrometry. 23:3457-3464
QuickQuan is an integrated software package for Thermo Scientific triple quadrupole mass spectrometers that allows users to automate routine operations ranging from method development to data processing. QuickQuan automated optimization of compound-s
Autor:
Robert Langish, Mark Sanders, Mary Ellen K. Salyan, James Smalley, Petia Shipkova, Dieter M. Drexler
Publikováno v:
Rapid Communications in Mass Spectrometry. 22:1359-1366
Triple quadrupole mass spectrometers are generally considered the instrument of choice for quantitative analysis. However, for the analysis of large peptides we have encountered some cases where, as the data presented here would indicate, ion trap ma
Publikováno v:
Journal of Chromatography B. 854:260-267
Caco-2 cells, the human colon carcinoma cells, are typically used for screening compounds for their permeability characteristics and P-glycoprotein (P-gp) interaction potential during discovery and development. The P-gp inhibition of test compounds i
Publikováno v:
Journal of Chromatography B. 830:270-277
Caco-2 cells are frequently used for screening compounds for their permeability characteristics and P-glycoprotein (P-gp) interaction potential. Bi-directional permeability studies performed on Caco-2 cells followed by analysis by HPLC-UV or LC-MS me
Autor:
Xiaoqin Liu, Yinong Xie, Paul G. Sleph, John A. Lupisella, Todd G. Kirchgessner, Rangaraj Narayanan, Denise Grimm, Ellen K. Kick, James Smalley, Jacek Ostrowski, Martin Richard, Glenn H. Cantor, Raju Mohan
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 352(2)
Liver X Receptors (LXRs) α and β are nuclear hormone receptors that regulate multiple genes involved in reverse cholesterol transport (RCT) and are potential drug targets for atherosclerosis. However, full pan agonists also activate lipogenic genes
Autor:
Yongxin Zhu, Bogdan Sleczka, Steven T. Wu, Baomin Xin, Timothy V Olah, John T Mehl, Dieter M. Drexler, James Smalley, Asoka Ranasinghe, Yulia Benitex, Richard L. Wong, Eric Shields, Hongwei Zhang
Publikováno v:
Characterization of Protein Therapeutics using Mass Spectrometry ISBN: 9781441978615
The search to discover and develop viable therapies for the treatment of diseases continues to branch out in new directions and to improve and incorporate more efficient strategies to identify drug molecules in a cost-effective manner. Although prove
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::80ba382f504cb5bdaeae3b679f822262
https://doi.org/10.1007/978-1-4419-7862-2_3
https://doi.org/10.1007/978-1-4419-7862-2_3