Zobrazeno 1 - 10
of 10
pro vyhledávání: '"James Schuman"'
Autor:
Min-Su Kim, Audrey Horst, Steven Blinka, Karl Stamm, Donna Mahnke, James Schuman, Rebekah Gundry, Aoy Tomita-Mitchell, John Lough
Publikováno v:
PLoS ONE, Vol 10, Iss 2, p e0118670 (2015)
The use of human pluripotent cell progeny for cardiac disease modeling, drug testing and therapeutics requires the ability to efficiently induce pluripotent cells into the cardiomyogenic lineage. Although direct activation of the Activin-A and/or Bmp
Externí odkaz:
https://doaj.org/article/ce0e311e55b24ac59e19f04d7d5e49df
Publikováno v:
The Journal of Immunology. 189:2326-2332
One of the important signaling events following TCR engagement is activation of phospholipase Cγ (PLCγ). PLCγ has two isoforms, PLCγ1 and PLCγ2. It is known that PLCγ1 is important for TCR signaling and TCR-mediated T cell selection and functio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::73e5ec3dba826af4cb058ce57c398acb
https://doi.org/10.4049/jimmunol.1103458
https://doi.org/10.4049/jimmunol.1103458
Autor:
Guoping Fu, Robert P. Stephan, Chunying Yang, James Schuman, Xuezhi Dai, Demin Wang, John L. Cleveland, Li Bai, Hu Zeng, Renren Wen, Yuhong Chen
Publikováno v:
Molecular and Cellular Biology. 26:9364-9376
Phospholipase Cgamma2 (PLCgamma2) is a critical signaling effector of the B-cell receptor (BCR). Here we show that PLCgamma2 deficiency impedes early B-cell development, resulting in an increase of B220+ CD43+ BP-1+ CD24hi pre-BCR+ large pre-B cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::996215357b1c075eb5435376a5905efb
https://doi.org/10.1128/mcb.00839-06
https://doi.org/10.1128/mcb.00839-06
Publikováno v:
Molecular and Cellular Biology. 26:88-99
During B-cell receptor (BCR) signaling, phosphoinositide-3 kinase (PI3K) is thought to function upstream of phospholipase Cgamma2 (PLCgamma2). PLCgamma2 deficiency specifically impedes transitional type 2 (T2) to follicular (FO) mature B-cell transit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da0a2ba39867c9f6218b5f0942beeaec
https://doi.org/10.1128/mcb.26.1.88-99.2006
https://doi.org/10.1128/mcb.26.1.88-99.2006
Autor:
Guoping Fu, Shoua Yang, Debra K. Newman, Demin Wang, Weiguo Zhang, James Schuman, Renren Wen, Yuhong Chen
Publikováno v:
The EMBO Journal. 23:4007-4017
Phospholipase Cgamma1 (PLCgamma1) has been reported to be expressed predominantly in T cells and to play an important role in T-cell receptor signaling. Here we show that PLCgamma1 is expressed throughout B-cell development, with high expression in B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2d50c1443500649b8fa73069694377d
https://doi.org/10.1038/sj.emboj.7600405
https://doi.org/10.1038/sj.emboj.7600405
Autor:
Demin Wang, Renren Wen, Stephan W. Morris, Yuhong Chen, Shoua Yang, James Schuman, Liquan Xue
Publikováno v:
Journal of Biological Chemistry. 278:43654-43662
PLCgamma2 plays a critical role in B cell receptor (BCR) signaling and its targeted deletion results in defective B cell development and function. Here, we show that PLCgamma2 deficiency specifically blocks B cell maturation at the transitional type
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::230c9f6fc56ee84c9b97358fc706e968
https://doi.org/10.1074/jbc.m307318200
https://doi.org/10.1074/jbc.m307318200
Autor:
James Schuman, Renren Wen, Yuhong Chen, Shoua Yang, Taolin Yi, Eric E. Zhang, Demin Wang, Gen-Sheng Feng
Publikováno v:
Journal of Biological Chemistry. 278:16520-16527
Stat5A, a member of the signal transducers and activators of transcription (Stat) family, is activated upon a single tyrosine phosphorylation. Although much is known about the activation process, the mechanism by which the tyrosine-phosphorylated Sta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c29389879fb26582ebd0b7af9102f2a7
https://doi.org/10.1074/jbc.m210572200
https://doi.org/10.1074/jbc.m210572200
Autor:
Zhijian J. Chen, James Schuman, Mei Yu, Demin Wang, Andrew Podd, Yuhong Chen, Renren Wen, Hong Hsing Liu
The kinase TAK1 is essential for T-cell receptor (TCR)–mediated nuclear factor κB (NF-κB) activation and T-cell development. However, the role of TAK1 in B-cell receptor (BCR)–mediated NF-κB activation and B-cell development is not clear. Here
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::375ee14462eb989e3d5aed31e52b648a
https://europepmc.org/articles/PMC2680363/
https://europepmc.org/articles/PMC2680363/
Autor:
John Lough, Donna K. Mahnke, Rebekah L. Gundry, Min-Su Kim, Karl Stamm, Steven Blinka, James Schuman, Audrey Horst, Aoy Tomita-Mitchell
Publikováno v:
PLoS ONE, Vol 10, Iss 2, p e0118670 (2015)
PLoS ONE
PLoS ONE
The use of human pluripotent cell progeny for cardiac disease modeling, drug testing and therapeutics requires the ability to efficiently induce pluripotent cells into the cardiomyogenic lineage. Although direct activation of the Activin-A and/or Bmp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1593ef5fa0e6133a50babb9890af5b7
https://doi.org/10.1371/journal.pone.0118670
https://doi.org/10.1371/journal.pone.0118670
Autor:
Renren Wen, Demin Wang, Lie Di, Paula E. North, James Schuman, Dipica Haribhai, Guoping Fu, Calvin B. Williams, Maryam Yassai, Andy Podd, Mei Yu, Jack Gorski, Yuhong Chen, Yinghong He
Publikováno v:
The Journal of Experimental Medicine
Phospholipase Cgamma1 (PLCgamma1) is an important signaling effector of T cell receptor (TCR). To investigate the role of PLCgamma1 in T cell biology, we generated and examined mice with T cell-specific deletion of PLCgamma1. We demonstrate that PLCg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4059db35fee72d8f591fbd5a935eb6f6
https://doi.org/10.1083/jcb1883oia4
https://doi.org/10.1083/jcb1883oia4