Zobrazeno 1 - 10
of 26
pro vyhledávání: '"James Samanen"'
Autor:
Richard M. Edwards, Judith Hempel, James Samanen, Richard M. Keenan, Eliot H. Ohlstein, Nambi Aiyar, David T. Hill, Joseph Weinstock
Publikováno v:
CHEMICAL and STRUCTURAL APPROACHES to RATIONAL DRUG DESIGN ISBN: 9781003068808
The renin-angiotensin system plays a key role in the regulation of blood pressure, fluid and electrolyte balance, and blood volume. In the initial step of the biochemical cascade, the proteolytic enzyme renin catalyzes the breakdown of the high-molec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::62e33755fcd17d576fc5f930bbec1e83
https://doi.org/10.1201/9781003068808-4
https://doi.org/10.1201/9781003068808-4
Autor:
Kevin L. Salyers, James Samanen, R. Curtis Haltiwanger, M.W. Lark, Leonard M. Azzarano, Irene N. Uzinskas, Karl F. Erhard, Robert N. Willette, Kyung O. Johanson, Catherine J. Gress, Stephen T Ross, Tian Li Yue, Keith W. Ward, William F. Huffman, Russell D. Cousins, Dirk A. Heerding, David J. Rieman, Shing Mei Hwang, Chet Kwon, Brian R. Smith, Ian E. James, William H. Miller, Catherine C.K. Yuan, Dennis T. Takata, Manley Peter J
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:1483-1486
In our continuing efforts to identify small molecule vitronectin receptor antagonists, we have discovered a series of phenylbutyrate derivatives, exemplified by 16, which have good potency and excellent oral bioavailability (approximately 100% in rat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b020a8d8d76827308cf4beb670e93f46
https://doi.org/10.1016/s0960-894x(03)00102-1
https://doi.org/10.1016/s0960-894x(03)00102-1
Autor:
James Samanen, Robert N. Willette, Frank C. Barone, Paul F. Koster, John R. Toomey, Richard E. Valocik
Publikováno v:
Current Drug Target -Cardiovascular & Hematological Disorders. 2:13-25
In patients with acute coronary syndromes, inhibition of platelet aggregation with parenteral alpha(IIb)/beta(III) antagonists has proven effective at preventing nonfatal myocardial infarction and repeat percutaneous coronary interventions. Paradoxic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25f5c2501ac52f82eae0a26cd6329224
https://doi.org/10.2174/1568006023337772
https://doi.org/10.2174/1568006023337772
Autor:
Richard M. Keenan, Steven T. Ross, M. Amparo Lago, S M Hwang, Eliot H. Ohlstein, Tian-Li Yue, David J. Rieman, Chet Kwon, Fadia E. Ali, Brian R. Smith, Lynne Vickery, Thomas T. Nguyen, Dalia R. Jakas, Russell D. Cousins, Calvert Louden, Jeffrey M. Stadel, Leon B. Hall, James Samanen, William H. Miller, Catherine C.K. Yuan, Dennis T. Takata
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 8:3171-3176
In the 3-oxo-1,4-benzodiazepine-2-acetic acid series of vitronectin receptor (alpha v beta 3) antagonists, a compound containing an imidazopyridine arginine mimetic was discovered which had sufficient potency and i.v. pharmacokinetics for demonstrati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcd994a9ec637d9aef7d70da2654228e
https://doi.org/10.1016/s0960-894x(98)00556-3
https://doi.org/10.1016/s0960-894x(98)00556-3
Publikováno v:
Tetrahedron Letters. 39:6815-6818
We show here the first example of a ruthenium catalyzed ene-yne metathesis reaction in tandem with a Diels-Alder cycloaddition reaction to efficiently form highly substituted hexahydroisoindole ring systems on Wang resin. This approach was used to pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cb5a94f9c98e99f4d949c95e80170be7
https://doi.org/10.1016/s0040-4039(98)01473-7
https://doi.org/10.1016/s0040-4039(98)01473-7
Publikováno v:
Current Pharmaceutical Design. 3:545-584
Abstract: During early investigations into the biology associated with the platelet integrin αlIbβ3, monoclonal antibodies to αllbβ3 indicated that an αllbβ3-like integrin was expressed on endothelial cells, smooth muscle cells and on a variety
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::51a817fda04f77048d2e4b71101f80b3
https://doi.org/10.2174/138161280306221010111710
https://doi.org/10.2174/138161280306221010111710
Autor:
James F. Callahan, Fadia E. Ali, S M Hwang, Catherine E. Peishoff, Chuan-Kui Yuan, Chet Kwon, Angela S. Wong, Kenneth D. Kopple, Richard M. Keenan, William F. Huffman, Raul R. Calvo, James Samanen, William H. Miller
Publikováno v:
Journal of Medicinal Chemistry. 40:2289-2292
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::55a449785e2ab209401f4c2b15ab7c84
https://doi.org/10.1021/jm970205r
https://doi.org/10.1021/jm970205r
Autor:
Philip L. Smith, Andrew J. Nichols, Tobias Oregon Yellin, Kenneth A. Newlander, Raul R. Calvo, James Samanen, Irene N. Uzinskas, Bondinell William E, Chao-Pin Lee, Michael W. Parker, Dalia R. Jakas
Publikováno v:
Advanced Drug Delivery Reviews. 23:133-142
A series of potent, high affinity GPIIb/IIIa antagonists were evaluated for intestinal permeability in vitro using rabbit intestinal strips mounted in the Ussing Chamber. In this series of compounds, structural modifications were found to impact inte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::350bdbddf76768ec56b4c8776c870467
https://doi.org/10.1016/s0169-409x(96)00431-0
https://doi.org/10.1016/s0169-409x(96)00431-0
Autor:
James Samanen
Successful drugs have a good return on investment by bringing in considerably more revenue than the expenses of discovery, development, and manufacturing. Successful drugs pay for all drug projects, those that fail and those that have yet to fail or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cd69bcb72c5059d56e5e5248e6b30cf5
https://doi.org/10.1016/b978-0-12-397176-0.00007-8
https://doi.org/10.1016/b978-0-12-397176-0.00007-8
Autor:
James Samanen
Biotechnology has given rise to a broad range of biotherapies or biologics, including biomolecular drugs, vaccines, cell or gene therapies. This chapter focuses on biomolecular drugs, namely monoclonal antibodies (Mabs), cytokines, tissue growth fact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8aa92d2f9974e9f210e8480ca50997a4
https://doi.org/10.1016/b978-0-12-397176-0.00005-4
https://doi.org/10.1016/b978-0-12-397176-0.00005-4