Zobrazeno 1 - 7
of 7
pro vyhledávání: '"James Sacchettini"'
Autor:
Christopher Burke, Monika Jankute, Patrick Moynihan, Ruben Gonzalez del Rio, Xiaojun Li, Jorge Esquivias, Joël Lelièvre, Jonathan A. G. Cox, James Sacchettini, Gurdyal S. Besra
Publikováno v:
FASEB BioAdvances, Vol 2, Iss 10, Pp 600-612 (2020)
Abstract Background Whole‐cell phenotypic screening is the driving force behind modern anti‐tubercular drug discovery efforts. Focus has shifted from screening for bactericidal scaffolds to screens incorporating target deconvolution. Target‐bas
Externí odkaz:
https://doaj.org/article/eb2f8e650da4477f88b62429bbec7c78
Autor:
Danish Khan, Dongju Lee, Gulcin Gulten, Anup Aggarwal, Joshua Wofford, Inna Krieger, Ashutosh Tripathi, John W Patrick, Debra M Eckert, Arthur Laganowsky, James Sacchettini, Paul Lindahl, Vytas A Bankaitis
Publikováno v:
eLife, Vol 9 (2020)
Yeast Sfh5 is an unusual member of the Sec14-like phosphatidylinositol transfer protein (PITP) family. Whereas PITPs are defined by their abilities to transfer phosphatidylinositol between membranes in vitro, and to stimulate phosphoinositide signali
Externí odkaz:
https://doaj.org/article/33c5c7c3d2734eef83d198b262875ae8
Autor:
Amanda J Martinot, Mary Farrow, Lu Bai, Emilie Layre, Tan-Yun Cheng, Jennifer H Tsai, Jahangir Iqbal, John W Annand, Zuri A Sullivan, M Mahmood Hussain, James Sacchettini, D Branch Moody, Jessica C Seeliger, Eric J Rubin
Publikováno v:
PLoS Pathogens, Vol 12, Iss 1, p e1005351 (2016)
Mycobacterium tuberculosis (Mtb) mutants lacking rv1411c, which encodes the lipoprotein LprG, and rv1410c, which encodes a putative efflux pump, are dramatically attenuated for growth in mice. Here we show that loss of LprG-Rv1410 in Mtb leads to int
Externí odkaz:
https://doaj.org/article/3122182a17664a31b85cc45e21e4b8b4
Autor:
Youngchang Kim, Christine Tesar, Joseph Mire, Robert Jedrzejczak, Andrew Binkowski, Gyorgy Babnigg, James Sacchettini, Andrzej Joachimiak
Publikováno v:
PLoS ONE, Vol 6, Iss 9, p e24621 (2011)
The New Delhi Metallo-β-lactamase (NDM-1) gene makes multiple pathogenic microorganisms resistant to all known β-lactam antibiotics. The rapid emergence of NDM-1 has been linked to mobile plasmids that move between different strains resulting in wo
Externí odkaz:
https://doaj.org/article/cb105b64899e41dd9b493fb98818bf62
Autor:
Elaine, Ballinger, John, Mosior, Travis, Hartman, Kristin, Burns-Huang, Ben, Gold, Roxanne, Morris, Laurent, Goullieux, Isabelle, Blanc, Julien, Vaubourgeix, Sophie, Lagrange, Laurent, Fraisse, Stéphanie, Sans, Cedric, Couturier, Eric, Bacqué, Kyu, Rhee, Sarah M, Scarry, Jeffrey, Aubé, Guangbin, Yang, Ouathek, Ouerfelli, Dirk, Schnappinger, Thomas R, Ioerger, Curtis A, Engelhart, Jennifer A, McConnell, Kathrine, McAulay, Allison, Fay, Christine, Roubert, James, Sacchettini, Carl, Nathan
Publikováno v:
Science (New York, N.Y.). 363(6426)
Publikováno v:
Journal of the American Chemical Society. 122:2178-2192
Starting with the published 2.0 A X-ray crystal structure of the transthyretin·(flufenamic acid)2 complex, a simple structure-based ligand design strategy was employed to conceive of N-phenyl phenoxazine transthyretin (TTR) amyloid fibril inhibitors
Autor:
Kreshna Gopal, Erik McKee, Tod Romo, Reetal Pai, Jacob Smith, James Sacchettini, Thomas Ioerger
Publikováno v:
Bioinformatics; Feb2007, Vol. 23 Issue 3, p375-377, 3p