Zobrazeno 1 - 10
of 83
pro vyhledávání: '"James S. Ultman"'
Publikováno v:
Applied Mathematical Modelling. 91:58-73
We present a three-dimensional dosimetry model to examine the influence of proximal airway deformations such as the tracheal deviation that often occur in the setting of fibrotic lung disease, on transport and uptake of inhaled reactive air pollutant
Publikováno v:
C45. EFFECTS OF THE ENVIRONMENT ON PULMONARY HEALTH.
Teaches the fundamentals of mass transport with a unique approach emphasizing engineering principles in a biomedical environment Includes a basic review of physiology, chemical thermodynamics, chemical kinetics, mass transport, fluid mechanics and re
Publikováno v:
Toxicology and Applied Pharmacology. 236:270-275
In nonsmokers, ozone (O 3 ) is removed primarily by the epithelial lining fluid (ELF) of the conducting airways. We hypothesized that cigarette smokers, whose ELF antioxidant capacity may be limited by smoking, would remove less O 3 from their conduc
Publikováno v:
Journal of Toxicology and Environmental Health, Part A. 71:166-195
Risk assessment of inhaled toxicants has typically focused upon adults, with modeling used to extrapolate dosimetry and risks from lab animals to humans. However, behavioral factors such as time spent playing outdoors may lead to more exposure to inh
Publikováno v:
Annals of Biomedical Engineering. 35:235-249
The pattern of lung injury induced by the inhalation of ozone (O(3)) depends on the dose delivered to different tissues in the airways. This study examined the distribution of O(3) uptake in a single, symmetrically branched airway bifurcation. Reacti
Publikováno v:
Archives of Biochemistry and Biophysics. 451:8-16
This study quantified the reaction kinetics of O3 with three low molecular weight antioxidants-uric acid (UA), ascorbic acid (AH2), and glutathione (GSH)-found in respiratory mucous. Using a semi-batch reactor in which a 500 ml/min flow of air contai
Publikováno v:
Toxicology and Applied Pharmacology. 213:1-9
The objectives of this study were to quantify pulmonary responses to ozone (O3) exposure by parameters computed from the carbon dioxide expirogram and to compare these responses to decrements in forced expired spirometry. Anatomical dead space (VD) w
Publikováno v:
Journal of Biomechanical Engineering. 128:69-75
In conventional one-dimensional single-path models, radially averaged concentration is calculated as a function of time and longitudinal position in the lungs, and coupled convection and diffusion are accounted for with a dispersion coefficient. The
Autor:
James S. Ultman, Wade H. Reeser, Genea M. Lee, Lan Wang, Adekemi B. Taylor, Steve F. Arnold, Abdellaziz Ben-Jebria
Publikováno v:
Inhalation Toxicology. 17:699-707
To investigate whether intersubject variations in the dose of inhaled ozone (O(3)) cause corresponding variations in the physiological response, 28 female and 32 male nonsmokers participated in a 1-h continuous inhalation of clean air or 0.25 ppm O(3