Zobrazeno 1 - 10
of 234
pro vyhledávání: '"James S. Trimmer"'
Autor:
Xiaomeng Han, Xiaotang Lu, Peter H. Li, Shuohong Wang, Richard Schalek, Yaron Meirovitch, Zudi Lin, Jason Adhinarta, Karl D. Murray, Leah M. MacNiven, Daniel R. Berger, Yuelong Wu, Tao Fang, Elif Sevde Meral, Shadnan Asraf, Hidde Ploegh, Hanspeter Pfister, Donglai Wei, Viren Jain, James S. Trimmer, Jeff W. Lichtman
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Mapping neuronal networks is a central focus in neuroscience. While volume electron microscopy (vEM) can reveal the fine structure of neuronal networks (connectomics), it does not provide molecular information to identify cell types or funct
Externí odkaz:
https://doaj.org/article/af6d34c529a5478a859e10bc1f1a99bb
Autor:
Collin Matsumoto, Samantha C. O’Dwyer, Declan Manning, Gonzalo Hernandez-Hernandez, Paula Rhana, Zhihui Fong, Daisuke Sato, Colleen E. Clancy, Nicholas C. Vierra, James S. Trimmer, L. Fernando Santana
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-21 (2023)
Abstract In arterial myocytes, the canonical function of voltage-gated CaV1.2 and KV2.1 channels is to induce myocyte contraction and relaxation through their responses to membrane depolarization, respectively. Paradoxically, KV2.1 also plays a sex-s
Externí odkaz:
https://doaj.org/article/550fd29c7daf4d55bbc32c60b1393140
Autor:
Keith G. Mitchell, Belvin Gong, Samuel S. Hunter, Diana Burkart-Waco, Clara E. Gavira-O’Neill, Kayla M. Templeton, Madeline E. Goethel, Malgorzata Bzymek, Leah M. MacNiven, Karl D. Murray, Matthew L. Settles, Lutz Froenicke, James S. Trimmer
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-20 (2023)
Abstract The Neuroscience Monoclonal Antibody Sequencing Initiative (NeuroMabSeq) is a concerted effort to determine and make publicly available hybridoma-derived sequences of monoclonal antibodies (mAbs) valuable to neuroscience research. Over 30 ye
Externí odkaz:
https://doaj.org/article/fa6b1a4ba7354527aeab55348adfee67
Autor:
Nicholas C. Vierra, Luisa Ribeiro-Silva, Michael Kirmiz, Deborah van der List, Pradeep Bhandari, Olivia A. Mack, James Carroll, Elodie Le Monnier, Sue A. Aicher, Ryuichi Shigemoto, James S. Trimmer
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Junctions between the endoplasmic reticulum (ER) and the plasma membrane (PM) are specialized membrane contacts ubiquitous in eukaryotic cells. Concentration of intracellular signaling machinery near ER-PM junctions allows these domains to s
Externí odkaz:
https://doaj.org/article/7f2913f73e5a47ccb468da67c35186d7
Autor:
Maria Casas, Karl D. Murray, Keiko Hino, Nicholas C. Vierra, Sergi Simó, James S. Trimmer, Rose E. Dixon, Eamonn J. Dickson
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-22 (2023)
Abstract Lysosomes communicate through cholesterol transfer at endoplasmic reticulum (ER) contact sites. At these sites, the Niemann Pick C1 cholesterol transporter (NPC1) facilitates the removal of cholesterol from lysosomes, which is then transferr
Externí odkaz:
https://doaj.org/article/8e457916b01b415d80b45482e83ca4c6
Epilepsy and neurobehavioral abnormalities in mice with a dominant-negative KCNB1 pathogenic variant
Autor:
Nicole A. Hawkins, Sunita N Misra, Manuel Jurado, Seok Kyu Kang, Nicholas C. Vierra, Kimberly Nguyen, Lisa Wren, Alfred L. George, Jr., James S. Trimmer, Jennifer A. Kearney
Publikováno v:
Neurobiology of Disease, Vol 147, Iss , Pp 105141- (2021)
Developmental and epileptic encephalopathies (DEE) are a group of severe epilepsies that usually present with intractable seizures, developmental delay, and often have elevated risk for premature mortality. Numerous genes have been identified as a mo
Externí odkaz:
https://doaj.org/article/3a83b62538ec4d4d97854b1d9c5a67df
Autor:
Nicholas C. Vierra, James S. Trimmer
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 4, p 1953 (2022)
The concerted function of the large number of ion channels expressed in excitable cells, including brain neurons, shapes diverse signaling events by controlling the electrical properties of membranes. It has long been recognized that specific groups
Externí odkaz:
https://doaj.org/article/9bc64e99071f4d368b5e28b0b814588a
Autor:
Jan L.A. Voskuil, Anita Bandrowski, C. Glenn Begley, Andrew R.M. Bradbury, Andrew D. Chalmers, Aldrin V. Gomes, Travis Hardcastle, Fridtjof Lund-Johansen, Andreas Plückthun, Giovanna Roncador, Alejandra Solache, Michael J. Taussig, James S. Trimmer, Cecilia Williams, Simon L. Goodman
Publikováno v:
mAbs, Vol 12, Iss 1 (2020)
In the wake of the reproducibility crisis and numerous discussions on how commercially available antibodies as research tool contribute to it, The Antibody Society developed a series of 10 webinars to address the issues involved. The webinars were de
Externí odkaz:
https://doaj.org/article/c2882a1d3d4c4f5fbfd4271ba95791db
Autor:
Anish K. Simhal, Belvin Gong, James S. Trimmer, Richard J. Weinberg, Stephen J Smith, Guillermo Sapiro, Kristina D. Micheva
Publikováno v:
Frontiers in Neuroanatomy, Vol 12 (2018)
Application-specific validation of antibodies is a critical prerequisite for their successful use. Here we introduce an automated framework for characterization and screening of antibodies against synaptic molecules for high-resolution immunofluoresc
Externí odkaz:
https://doaj.org/article/34c5fa5850fa4589b67c999545c27e4b
Autor:
Denise Riquelme, Ian Silva, Ashleigh M. Philp, Juan P. Huidobro-Toro, Oscar Cerda, James S. Trimmer, Elias Leiva-Salcedo
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 12 (2018)
TRPM4 is a Ca2+-activated non-selective cationic channel that conducts monovalent cations. TRPM4 has been proposed to contribute to burst firing and sustained activity in several brain regions, however, the cellular and subcellular pattern of TRPM4 e
Externí odkaz:
https://doaj.org/article/91fb8267fd3849118bbe1e529cde222b