Zobrazeno 1 - 10
of 18
pro vyhledávání: '"James S. Swaney"'
Autor:
Matthew Spellman, Utako Yokoyama, James S. Swaney, David M. Roth, Paul A. Insel, Hemal H. Patel, N. Chin Lai
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 293:H3216-H3220
Myocardial infarction (MI) results in left ventricular remodeling (e.g., ventricular hypertrophy, dilatation, and fibrosis). Fibrosis contributes to increased myocardial stiffening, impaired ventricular filling and function, and reduced cardiac outpu
Autor:
Hemal H. Patel, Ingrid R. Niesman, David M. Roth, Marilyn G. Farquhar, Fiona Murray, Paul A. Insel, James S. Swaney, Brian P. Head
Publikováno v:
Journal of Biological Chemistry. 281:26391-26399
Microtubules and actin filaments regulate plasma membrane topography, but their role in compartmentation of caveolae-resident signaling components, in particular G protein-coupled receptors (GPCR) and their stimulation of cAMP production, has not bee
Publikováno v:
Journal of Biological Chemistry. 281:17173-17179
Fibroblast-myofibroblast transformation, a critical event for enhanced extracellular matrix deposition, involves formation of an actin stress fiber contractile apparatus that radiates from focal adhesions (FA) in the plasma membrane. Activation of ad
Autor:
Brian P. Head, Paul A. Insel, David M. Roth, Rennolds S. Ostrom, Hemal H. Patel, Chih-Min Tang, James S. Swaney
Publikováno v:
Annals of the New York Academy of Sciences. 1047:166-172
A growing body of data indicates that multiple signal transduction events in the heart occur via plasma membrane receptors located in signaling microdomains. Lipid rafts, enriched in cholesterol and sphingolipids, form one such microdomain along with
Autor:
James S. Swaney, H. Kirk Hammond, Jeffrey D. Drumm, Valmik Bhargava, David M. Roth, Mei Hua Gao
Publikováno v:
Basic Research in Cardiology. 98:380-387
Mice with cardiac-directed overexpression of AC(VI) show increased cardiac responsiveness to beta-adrenergic receptor stimulation but regulation of heart rate is unknown. Telemetry was used to test the hypothesis that mice overexpressing cardiac aden
Autor:
Jennifer E. Naugle, Caroline Gregorian, Laurence L. Brunton, Miki Hase, J. Gary Meszaros, James S. Swaney, Rennolds S. Ostrom, Paul A. Insel
Publikováno v:
Journal of Biological Chemistry. 278:24461-24468
Cardiac fibroblasts regulate formation of extracellular matrix in the heart, playing key roles in cardiac remodeling and hypertrophy. In this study, we sought to characterize cross-talk between Gq and Gs signaling pathways and its impact on modulatin
Autor:
Patricia Prodanovich, Daniel S. Lorrain, Timothy Parr, Jeffrey Roger Roppe, Jeannie Ziff, Angelina M. Santini, Christopher D. King, Catherine Lee, Karin J. Stebbins, James S. Swaney, Jilly F. Evans, Hutchinson John H, Peppi Prasit, Christopher Baccei, Lucia Correa, Thomas Jon Seiders, Gretchen Bain, Charles Chapman, Alex R. Broadhead
Publikováno v:
B28. SCARRING IN THE LUNG: PRINCIPLES AND PERSPECTIVES.
Autor:
Andrew D. Luster, Christopher D. King, Flavia V. Castelino, Gretchen Bain, Jon Seiders, Daniel S. Lorrain, Jerold Chun, Andrew M. Tager, Sarah F. Brooks, James S. Swaney
Publikováno v:
Arthritis and rheumatism. 63(5)
Scleroderma (systemic sclerosis [SSc]), is characterized by progressive multiorgan fibrosis. We recently implicated lysophosphatidic acid (LPA) in the pathogenesis of pulmonary fibrosis. The purpose of the present study was to investigate the roles o
Autor:
Jeffrey Roger Roppe, Angelina M. Santini, Daniel S. Lorrain, Charles Chapman, Jilly F. Evans, Christopher D. King, Catherine Lee, Karin J. Stebbins, Alex R. Broadhead, Lucia Correa, Timothy Parr, Chris Baccei, Peppi Prasit, Thomas Jon Seiders, Hutchinson John H, Gretchen Bain, Jeannie Ziff, Janice Darlington, James S. Swaney
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 336(3)
Lysophosphatidic acid (LPA) is a bioactive phospholipid that signals through a family of at least six G protein-coupled receptors designated LPA₁₋₆. LPA type 1 receptor (LPA₁) exhibits widespread tissue distribution and regulates a variety of
Autor:
Ralph T. Schermuly, Jason X.-J. Yuan, Brian P. Head, Paul A. Insel, Marilyn G. Farquhar, Shen Zhang, James S. Swaney, Utako Yokoyama, Hemal H. Patel, Atsushi Miyanohara, Fiona Murray, Soni Savai Pullamsetti, Patricia A. Thistlethwaite, Ingrid R. Niesman, Ryan Y. S. Suda
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 21(11)
Vasoconstriction and vascular medial hypertrophy, resulting from increased intracellular [Ca2+] in pulmonary artery smooth muscle cells (PASMC), contribute to elevated vascular resistance in patients with idiopathic pulmonary arterial hypertension (I