Zobrazeno 1 - 10
of 77
pro vyhledávání: '"James S. Hatfield"'
Autor:
James S. Hatfield, Neeliyath A. Ramakrishnan, Marian J. Drescher, Dennis G. Drescher, Khalid Mohammed Khan
Publikováno v:
Journal of Biological Chemistry. 287:37628-37646
A unique coupling between HCN1 and stereociliary tip-link protein protocadherin 15 has been described for a teleost vestibular hair-cell model and mammalian organ of Corti (OC) (Ramakrishnan, N. A., Drescher, M. J., Barretto, R. L., Beisel, K. W., Ha
Autor:
N. Volkan Adsay, Martin Tobi, Douglas B. Evans, Suzanne E. G. Fligiel, James S. Hatfield, Mijin Kim, Edi Levi, Mary Ann Rambus, Michael J. Lawson, Douglas Weinstein
Publikováno v:
Digestive Diseases and Sciences. 58:744-750
Sporadic pancreatic ductal adenocarcinoma (PDA) is a highly lethal cancer. No proven screening strategies are available and frequent cross-sectional imaging studies (CT/MRI) are impractical even in patients thought to be at higher risk than the gener
Autor:
James S. Hatfield, Marian J. Drescher, Neeliyath A. Ramakrishnan, Jayme R. Dowdall, Dennis G. Drescher, Khalid M. Khan, Dakshnamurthy Selvakumar
Publikováno v:
Biochemical Journal. 443:463-476
The molecular characteristics of CNG (cyclic nucleotide-gated) channels in auditory/vestibular hair cells are largely unknown, unlike those of CNG mediating sensory transduction in vision and olfaction. In the present study we report the full-length
Autor:
Marcia I. Dawson, James S. Hatfield, Farhan Murshed, Jayanta Kumar Das, Lulu Farhana, Zebin Xia, Timothy Hadden, Joseph A. Fontana
Publikováno v:
Journal of Oncology
Journal of Oncology, Vol 2012 (2012)
Journal of Oncology, Vol 2012 (2012)
Pancreatic carcinoma has a dismal prognosis as it often presents as locally advanced or metastatic. We have found that exposure to adamantyl-substituted retinoid-related (ARR) compounds 3-Cl-AHPC and AHP3 resulted in growth inhibition and apoptosis i
Autor:
Qing Yan, William J. Kupsky, Xuebao Zhang, Jiasong Guo, Jun Li, Istvan Katona, Michael E. Shy, James S. Hatfield, Yunhong Bai
Publikováno v:
European Journal of Neuroscience. 33:1401-1410
Loss of function of the FIG4 gene causes Charcot-Marie-Tooth disease (CMT)-4J with many features also found in motor neuron disease (MND). Mechanisms for the degeneration are unknown. We investigated this using Fig4-deficient pale tremor (plt) mice,
Autor:
Zebin Xia, Joseph A. Fontana, Lulu Farhana, Amro Aboukameel, Marcia I. Dawson, Ramzi M. Mohammad, Gang Liu, Edi Levi, Liping Xu, James S. Hatfield, Jayanta Kumar Das
Publikováno v:
Molecular Cancer Therapeutics. 9:2903-2913
The adamantyl-substituted retinoid-related (ARR) compounds 3-Cl-AHPC and AHP3 induce apoptosis in vitro and in vivo in a newly established human acute myelogenous leukemia (AML) cell line, FFMA-AML, and in the established TF(v-SRC) AML cell line. FFM
Autor:
Roberto L. Barretto, Dennis G. Drescher, Marian J. Drescher, James S. Hatfield, Neeliyath A. Ramakrishnan, Kirk W. Beisel
Publikováno v:
Journal of Biological Chemistry. 284:3227-3238
The cytoplasmic amino terminus of HCN1, the primary full-length HCN isoform expressed in trout saccular hair cells, was found by yeast two-hybrid protocols to bind the cytoplasmic carboxyl-terminal domain of a protocadherin 15a-like protein. HCN1 was
Autor:
Suzanne E. G. Fligiel, Thomas J. McGarrity, Nadeem Ullah, Carolyn Cole, Violeta Yordanova, Paula Sochacki, Michael Kam, Kashif Qureshi, Michael J. Lawson, Russell Jacoby, Martin Tobi, James S. Hatfield
Publikováno v:
Digestive Diseases and Sciences. 53:723-729
Patients with the hamartomatous polyposis Peutz-Jeghers and familial juvenile polyposis syndromes are predisposed to colorectal cancer but lack early genetic alterations found in adenomatous premalignant lesions. We studied hamartomatous polyps for t
Autor:
Jianhua Du, Ramzi M. Mohammad, Yingjie Yu, Volkan Adsay, Amro Aboukameel, James S. Hatfield, Edi Levi, Adhip P.N. Majumdar, Anil Wali, Liyue Zhang, Hu Xu, Pralay Majumder, Arun K. Rishi
Publikováno v:
Molecular Cancer Therapeutics. 6:1661-1672
Deregulated signaling by the epidermal growth factor receptor family of proteins is encountered in human malignancies including breast cancer. Cell cycle and apoptosis-regulatory protein-1 (CARP-1), a novel, perinuclear phosphoprotein, is a regulator
Autor:
Marian J. Drescher, James S. Hatfield, Neeliyath A. Ramakrishnan, Dennis G. Drescher, Khalid M. Khan
Publikováno v:
Journal of Neuroscience Research. 85:3000-3012
Alpha(1)-, beta(1)-, and beta(2)-adrenergic receptors (ARs), which mediate responses to adrenergic input, have been immunohistochemically identified within the organ of Corti and spiral ganglion with polyclonal antibodies of established specificity.