Výsledky vyhledávání - "James S. Foulke"

Akademický článek

Stoichiometric Analyses of Soluble CD4 to Native-like HIV-1 Envelope by Single-Molecule Fluorescence Spectroscopy

Autor: Parul Agrawal, Anthony L. DeVico, James S. Foulke, Jr., George K. Lewis, Marzena Pazgier, Krishanu Ray

Publikováno v: Cell Reports, Vol 29, Iss 1, Pp 176-186.e4 (2019)

Summary: Analyses of HIV-1 envelope (Env) binding to CD4, and the conformational changes the interactions induce, inform the molecular mechanisms and factors governing HIV-1 infection. To address these questions, we used a single-molecule detection (

Externí odkaz: https://doaj.org/article/7d6c01ebc57c4dc69bff09b248636809

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Patterns of conserved gp120 epitope presentation on attached HIV-1 virions

Autor: George K. Lewis, Mileidy Gonzalez, Anthony L. DeVico, Meron Mengistu, John L. Spouge, Robert C. Gallo, James S. Foulke, Thomas A. Blanpied, Ai-Hui Tang

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America

Significance A complete picture of HIV antigenicity during early replication is needed to elucidate the full range of options for controlling infection through humoral immunity. The HIV envelope protein, gp120, experiences key structural rearrangemen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef13184850f6120094c078c251758c90
http://europepmc.org/articles/PMC5699032

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Monotherapy with either dolutegravir or raltegravir fails to durably suppress HIV viraemia in humanized mice

Autor: Said Hassounah, Nhut Le, Alonso Heredia, Yingshan Han, Robert R. Redfield, Mark A. Wainberg, Joseph Bryant, Charles E. L. B. Davis, Juan C. Zapata, James S. Foulke, Sandra Medina-Moreno

To compare the effectiveness of HIV integrase inhibitor monotherapy between raltegravir and dolutegravir as an approach to simplify therapy.We evaluated and compared the efficacy of 20 week monotherapy with dolutegravir or raltegravir in humanized mi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3eeedc66f9c0f301ff7c95945bc0e46
https://europepmc.org/articles/PMC5890682/

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Synergistic inhibition of R5 HIV-1 by maraviroc and CCR5 antibody HGS004 in primary cells: implications for treatment and prevention

Autor: Nhut Le, Alonso Heredia, Anthony L. DeVico, Robert R. Redfield, Ranajit Pal, Olga Latinovic, James S. Foulke, Marvin S. Reitz

Publikováno v: AIDS. 25:1232-1235

CCR5 serves as the main coreceptor for the predominantly transmitted and most persistent HIV-1, the R5 strains. Maraviroc (MVC) is the only licensed CCR5 inhibitor [1, 2]. CCR5 antibodies PRO 140 and HGS004 have significantly reduced HIV-1 RNA in cli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e63f9badc9d5a275a54f04f54aea8bfd
https://doi.org/10.1097/qad.0b013e3283471edb

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Suppression of MIP-1β transcription in human T cells is regulated by inducible cAMP early repressor (ICER)

Autor: James S. Foulke, Oxana Barabitskaja, Marvin S. Reitz, Shibani Pati, Josef Bodor

Publikováno v: Journal of Leukocyte Biology. 79:378-387

Local production of macrophage inflammatory protein-1β (MIP-1β), a β-chemokine that blocks human immunodeficiency virus type 1 (HIV-1) entry into CD4+ CC chemokine receptor 5+ target cells, may be a significant factor in resistance to HIV-1 infect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed4a9b0a44aa961399ebad0fbacf02d2
https://doi.org/10.1189/jlb.0505255

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Structural definition of an antibody-dependent cellular cytotoxicity response implicated in reduced risk for HIV-1 infection

Publikováno v: Journal of Virology
Journal of Virology, American Society for Microbiology, 2014, 88 (21), pp.12895-12906. ⟨10.1128/JVI.02194-14⟩
Journal of Virology, 2014, 88 (21), pp.12895-12906. ⟨10.1128/JVI.02194-14⟩

The RV144 vaccine trial implicated epitopes in the C1 region of gp120 (A32-like epitopes) as targets of potentially protective antibody-dependent cellular cytotoxicity (ADCC) responses. A32-like epitopes are highly immunogenic, as infected or vaccina

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b363df609305a6033fb6fdb88b393fe9
https://pubmed.ncbi.nlm.nih.gov/25165110

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Targeting of the Purine Biosynthesis Host Cell Pathway Enhances the Activity of Tenofovir Against Sensitive and Drug-Resistant HIV-1

Autor: Charles E. L. B. Davis, Mark A. Wainberg, Lai-Xi Wang, Robert R. Redfield, Marvin S. Reitz, Nhut Le, Alonso Heredia, James S. Foulke

Global programs expanding access to antiretroviral treatments represent a highly successful public health intervention [1]. To date, >6 million persons living with human immunodeficiency virus type 1 (HIV-1) infection have received antiviral treatmen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a13164473050a62604783ddd59716f7a
https://europepmc.org/articles/PMC3836462/

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Integrative Cloning, Expression, and Stability of the cryIA(c) Gene from Bacillus thuringiensis subsp. kurstaki in a Recombinant Strain of Clavibacter xyli subsp. cynodontis

Autor: James S. Foulke, Jeffrey L. Kelly, Gayle L. Canter, James J. Anderson, John T. Turner, Brenda B. Uratani, J S Lampel, Michael B. Dimock

Publikováno v: Applied and Environmental Microbiology. 60:501-508

A bacterial endophyte was engineered for insecticidal activity against the European corn borer. The cryIA(c) gene from Bacillus thuringiensis subsp. kurstaki was introduced into the chromosome of Clavibacter xyli subsp. cynodontis by using an integra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::19191aec13b7a0dade418203c45f6241
https://doi.org/10.1128/aem.60.2.501-508.1994

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CCR5 antibodies HGS004 and HGS101 preferentially inhibit drug-bound CCR5 infection and restore drug sensitivity of Maraviroc-resistant HIV-1 in primary cells

Autor: Robert R. Redfield, Clara Lehmann, Marvin S. Reitz, Gerd Fätkenheuer, Olga Latinovic, James S. Foulke, Nhut Le, Alonso Heredia

R5 HIV-1 strains resistant to the CCR5 antagonist Maraviroc (MVC) can use drug-bound CCR5. We demonstrate that MVC-resistant HIV-1 exhibits delayed kinetics of coreceptor engagement and fusion during drug-bound versus free CCR5 infection of cell line

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::319e003e0a30fbde135ca2af384c59da
https://europepmc.org/articles/PMC3039059/

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