Zobrazeno 1 - 10
of 197
pro vyhledávání: '"James S Wiley"'
Autor:
Catherine M Miller, Alana M Zakrzewski, Dionne P Robinson, Stephen J Fuller, Robert A Walker, Rowan J Ikin, Shisan J Bao, Michael E Grigg, James S Wiley, Nicholas C Smith
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0129048 (2015)
BackgroundOral infection of C57BL/6J mice with the protozoan parasite Toxoplasma gondii leads to a lethal inflammatory ileitis.Principal findingsMice lacking the purinergic receptor P2X7R are acutely susceptible to toxoplasmic ileitis, losing signifi
Externí odkaz:
https://doaj.org/article/20b79e2550284248966e56543561492e
Autor:
Catherine M Miller, Nicola R Boulter, Stephen J Fuller, Alana M Zakrzewski, Michael P Lees, Bernadette M Saunders, James S Wiley, Nicholas C Smith
Publikováno v:
PLoS Pathogens, Vol 7, Iss 11, p e1002212 (2011)
ATP is an extracellular signal for the immune system, particularly during an inflammatory response. It is sensed by the P2X₇ receptor, the expression of which is upregulated by pro-inflammatory cytokines. Activation of the P2X₇ receptor opens a c
Externí odkaz:
https://doaj.org/article/eaae2f5f8dfd4171bed244a273cb96bf
Autor:
Joelyn Wong, Ben J. Gu, Harry Teoh, Malgorzata Krupa, Mastura Monif, Mark Slee, James S. Wiley
Publikováno v:
Platelets, Vol 33, Iss 4, Pp 621-631 (2022)
Platelets express P2X1 receptors and our data also show the expression of P2X7 receptors. We studied the role of both receptors in platelet apoptosis by incubation of PRP with P2X agonists, then centrifuged to remove viable platelets, and analyzed th
Externí odkaz:
https://doaj.org/article/b6de5b1298f249f9ade198faf80948d7
Autor:
Xin Huang, Yihan Li, Christopher Fowler, James D. Doecke, Yen Ying Lim, Candace Drysdale, Vicky Zhang, Keunha Park, Brett Trounson, Kelly Pertile, Rebecca Rumble, John W. Pickering, Robert A. Rissman, Floyd Sarsoza, Sara Abdel‐Latif, Yong Lin, Vincent Doré, Victor Villemagne, Christopher C. Rowe, Jurgen Fripp, Ralph Martins, James S. Wiley, Paul Maruff, Jacobo E. Mintzer, Colin L. Masters, Ben J. Gu
Publikováno v:
Alzheimer's & Dementia. 19:2084-2094
Blood-based diagnostics and prognostics in sporadic Alzheimer's disease (AD) are important for identifying at-risk individuals for therapeutic interventions.In three stages, a total of 34 leukocyte antigens were examined by flow cytometry immunopheno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34bf0b2975507ade597946d9ddd753bf
https://doi.org/10.1002/alz.12813
https://doi.org/10.1002/alz.12813
Leukocyte Surface Biomarkers Implicate Deficits of Innate Immunity in Late‐onset Alzheimer’s Disease
Autor:
Yihan Li, Xin Huang, Christopher Fowler, James D Doecke, Brett Trounson, Kelly Pertile, Rebecca Rumble, Yen Ying Lim, Paul Maruff, Jacobo E. Mintzer, Vincent Dore, Christopher Rowe, Jurgen Fripp, James S Wiley, Colin L. Masters, Ben J Gu
Publikováno v:
Alzheimer's & Dementia. 18
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ffddeb917f67fd2eea669eb6b4ee15ea
https://doi.org/10.1002/alz.065030
https://doi.org/10.1002/alz.065030
Autor:
Yihan Li, Colin L. Masters, Xin Huang, Luke A. Miles, Simon M. Laws, James S. Wiley, Ben J. Gu
Publikováno v:
Cellular and Molecular Life Sciences. 78:7397-7426
Alzheimer's disease (AD) is a chronic neurodegenerative disease characterised by cognitive impairment, behavioural alteration, and functional decline. Over 130 AD-associated susceptibility loci have been identified by genome-wide association studies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c1ee861a64f1cd1982ca197a5014c1cd
https://doi.org/10.1007/s00018-021-03986-5
https://doi.org/10.1007/s00018-021-03986-5
Autor:
Hui Li, Erin Cvejic, Denis Wakefield, Ian B. Hickie, Tracey A Davenport, Andrew R. Lloyd, Ben J. Gu, James S. Wiley, Ute Vollmer-Conna
Publikováno v:
The Journal of Infectious Diseases. 224:914-920
Background The acute sickness response to infection is a stereotyped set of illness manifestations initiated by proinflammatory signals in the periphery but mediated centrally. P2RX7 is a highly polymorphic gene encoding an ATP-gated cationic pore, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9248c1e81858b8891b3757b179a3187
https://doi.org/10.1093/infdis/jiab027
https://doi.org/10.1093/infdis/jiab027
Autor:
Xin Huang, Feng Chen, Larissa Doughty, Qiao-Xin Li, Wensi Ou, Yihan Li, Candace Drysdale, Arwa Alrehaili, Ian E. Birchall, Joelyn Wong, Keunha Park, Michael Lim, Mujun Sun, Bridgette D. Semple, Sandy R. Shultz, Paul A. Adlard, Michael W. Parker, Michael McKinley, Colin L. Masters, James S. Wiley, Ben J Gu
Background: We and others have reported that glatiramer acetate promotes innate phagocytosis. Methods: In this study, we investigated the interaction between glatiramer acetate and amyloid-β (Aβ) by using circular dichroism and microscale thermopho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eda7775c40369845e4a43101ac99f0e3
https://doi.org/10.21203/rs.3.rs-1524708/v1
https://doi.org/10.21203/rs.3.rs-1524708/v1
Autor:
Candace Drysdale, Keunha Park, Kirstan A. Vessey, Xin Huang, Emily Caruso, Yihan Li, Joelyn Wong, James S. Wiley, Erica Fletcher, Robyn H. Guymer, Ben J. Gu
Publikováno v:
Purinergic Signal
We have shown deficits in monocyte phagocytosis from patients with age-related macular degeneration (AMD). Cell membrane fluidity is known to affect phagocytic capacity and leucocyte functionality more generally. Therefore, we examined membrane fluid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::596f0f69e27f64c651124a25b7d17e0d
https://pubmed.ncbi.nlm.nih.gov/36001279
https://pubmed.ncbi.nlm.nih.gov/36001279
Autor:
Leanne Stokes, Rachel Glover, Michael D. Lovelace, Steven Petrou, Ben J. Gu, James S. Wiley, Carol J. Milligan, Kristen K. Skarratt, Stephen J. Fuller
Publikováno v:
The FASEB Journal. 34:3884-3901
P2X7 is an ATP-gated membrane ion channel that is expressed by multiple cell types. Brief exposure to ATP induces the opening of a nonselective cation channel; while repeated or prolonged exposure induces formation of a transmembrane pore. This proce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::159a5b63b01519f4d93eba121277cc5f
https://doi.org/10.1096/fj.201901198rr
https://doi.org/10.1096/fj.201901198rr