Zobrazeno 1 - 10
of 104
pro vyhledávání: '"James S O, McCullagh"'
Autor:
Rebecca Clarke, Tehmina Bharucha, Benediktus Yohan Arman, Bevin Gangadharan, Laura Gomez Fernandez, Sara Mosca, Qianqi Lin, Kerlijn Van Assche, Robert Stokes, Susanna Dunachie, Michael Deats, Hamid A. Merchant, Céline Caillet, John Walsby-Tickle, Fay Probert, Pavel Matousek, Paul N. Newton, Nicole Zitzmann, James S. O. McCullagh
Publikováno v:
npj Vaccines, Vol 9, Iss 1, Pp 1-14 (2024)
Abstract The global population is increasingly reliant on vaccines to maintain population health with billions of doses used annually in immunisation programmes. Substandard and falsified vaccines are becoming more prevalent, caused by both the degra
Externí odkaz:
https://doaj.org/article/f005fcfa3a62421b8cb44d66f94b298d
Autor:
Chee Kin Then, Salome Paillas, Aliu Moomin, Mariya D. Misheva, Rachel A. Moir, Susan M. Hay, David Bremner, Kristine S. Roberts (nee Nellany), Ellen E. Smith, Zeynab Heidari, Daniel Sescu, Xuedan Wang, Alejandro Suárez-Bonnet, Nadine Hay, Sarah L. Murdoch, Ryoichi Saito, Elaina S. R. Collie-Duguid, Shirley Richardson, Simon L. Priestnall, Joan M. Wilson, Mahalakshmi Gurumurthy, Justine S. Royle, Leslie M. Samuel, George Ramsay, Katherine A. Vallis, Kevin R. Foster, James S. O. McCullagh, Anne E. Kiltie
Publikováno v:
Microbiome, Vol 12, Iss 1, Pp 1-22 (2024)
Abstract Background Non-toxic approaches to enhance radiotherapy outcomes are beneficial, particularly in ageing populations. Based on preclinical findings showing that high-fibre diets sensitised bladder tumours to irradiation by modifying the gut m
Externí odkaz:
https://doaj.org/article/b90bc4a81c81485ab1f36d54138de454
Autor:
Ceren Yalaz, Esther Bridges, Nasullah K. Alham, Christos E. Zois, Jianzhou Chen, Karim Bensaad, Ana Miar, Elisabete Pires, Ruth J. Muschel, James S. O. McCullagh, Adrian L. Harris
Publikováno v:
Cancer & Metabolism, Vol 12, Iss 1, Pp 1-26 (2024)
Abstract Background PDE6H encodes PDE6γ′, the inhibitory subunit of the cGMP-specific phosphodiesterase 6 in cone photoreceptors. Inhibition of PDE6, which has been widely studied for its role in light transduction, increases cGMP levels. The purp
Externí odkaz:
https://doaj.org/article/a0980800c2ff4d25880a8bc551833cad
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract The characterization of archaeological metal corrosion has traditionally been limited to the identification of inorganic compounds usually by X-ray diffraction (XRD), thought to result from the interaction between the metal object and the de
Externí odkaz:
https://doaj.org/article/fe0673d8843f4e5392cc0c6753422027
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-9 (2022)
Abstract We analysed corrosion from a copper bowl dating from the Roman period (43–410 AD) found in a farm in Kent, UK. Despite its relatively good condition, the interior and exterior surface of the object had areas of deterioration containing gre
Externí odkaz:
https://doaj.org/article/9adfb816c82b4798bbdddc29b0ebf7a9
Autor:
Raphael Reinbold, Ingvild C. Hvinden, Patrick Rabe, Ryan A. Herold, Alina Finch, James Wood, Melissa Morgan, Maximillian Staudt, Ian J. Clifton, Fraser A. Armstrong, James S. O. McCullagh, Jo Redmond, Chiara Bardella, Martine I. Abboud, Christopher J. Schofield
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
The development of IDH variant inhibitors is a breakthrough as it is the first time metabolism has been successfully targeted by small molecule drugs in cancer. Here the authors report studies on resistance to the pioneer drug ivosidenib leading to i
Externí odkaz:
https://doaj.org/article/e3e859d6d730417f8d6ec356de38fe1b
Autor:
Christos E. Zois, Anne M. Hendriks, Syed Haider, Elisabete Pires, Esther Bridges, Dimitra Kalamida, Dimitrios Voukantsis, B. Christoffer Lagerholm, Rudolf S. N. Fehrmann, Wilfred F. A. den Dunnen, Andrei I. Tarasov, Otto Baba, John Morris, Francesca M. Buffa, James S. O. McCullagh, Mathilde Jalving, Adrian L. Harris
Publikováno v:
Cell Death and Disease, Vol 13, Iss 6, Pp 1-15 (2022)
Abstract Channelling of glucose via glycogen, known as the glycogen shunt, may play an important role in the metabolism of brain tumours, especially in hypoxic conditions. We aimed to dissect the role of glycogen degradation in glioblastoma (GBM) res
Externí odkaz:
https://doaj.org/article/b1ef617fb3104ffda4ec574e955e7b3f
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-16 (2022)
Abstract Silk has been a luxurious commodity throughout modern human history and sericulture has played an important role in ancient global trade as well as technological and cultural developments. Archaeological findings suggest that prior to domest
Externí odkaz:
https://doaj.org/article/5ff2554633d5425abecfa64cf3312b21
Autor:
Shuang Liu, Martine I. Abboud, Tobias John, Victor Mikhailov, Ingvild Hvinden, John Walsby-Tickle, Xiao Liu, Ilaria Pettinati, Tom Cadoux-Hudson, James S. O. McCullagh, Christopher J. Schofield
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-16 (2021)
Liu et al investigate the effects of divalent metal ions on catalysis and inhibition of the enzyme isocitrate dehydrogenase (IDH) and its cancer-linked variant R132H. They further identify the substrates for IDH as complexes with Mg2+ and show that a
Externí odkaz:
https://doaj.org/article/87f044b46ee747dba26b0e27f7cc54e6
Autor:
Alun Vaughan-Jackson, Szymon Stodolak, Kourosh H. Ebrahimi, Errin Johnson, Paul K. Reardon, Maeva Dupont, Shengpan Zhang, James S. O. McCullagh, William S. James
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Macrophage distribution density is tightly regulated within the body, yet the importance of macrophage crowding during in vitro culture is largely unstudied. Using a human induced pluripotent stem cell (iPSC)-derived macrophage model of tissue reside
Externí odkaz:
https://doaj.org/article/9f8886a412c84bcbb1ed246d71b4d3a9