Zobrazeno 1 - 10
of 47
pro vyhledávání: '"James S Gibbs"'
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e33072 (2012)
Aminoacyl-tRNA synthetases (ARSs) are critical components of protein translation, providing ribosomes with aminoacyl-tRNAs. In return, ribosomes release uncharged tRNAs as ARS substrates. Here, we show that tRNA deacylation can be uncoupled from prot
Externí odkaz:
https://doaj.org/article/39f23fdb734e429e90f254385b527ba4
Autor:
Scott E Hensley, Suman R Das, James S Gibbs, Adam L Bailey, Loren M Schmidt, Jack R Bennink, Jonathan W Yewdell
Publikováno v:
PLoS ONE, Vol 6, Iss 2, p e15190 (2011)
Drugs inhibiting the influenza A virus (IAV) neuraminidase (NA) are the cornerstone of anti-IAV chemotherapy and prophylaxis in man. Drug-resistant mutations in NA arise frequently in human isolates, limiting the therapeutic application of NA inhibit
Externí odkaz:
https://doaj.org/article/a2918f031411439db2d136499f4de716
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Tissue-resident memory (TRM) CD8+ T cells are largely derived from recently activated effector T cells, but the mechanisms that control the extent of TRM differentiation within tissue microenvironments remain unresolved. Here, using an IFNγ
Externí odkaz:
https://doaj.org/article/98659d4192e840ac935c48162957b947
Autor:
Kartikeya Vijayasimha, Amy L. Leestemaker-Palmer, James S. Gibbs, Jonathan W. Yewdell, Brian P. Dolan
Successful direct MHC class I antigen presentation is dependent on the protein degradation machinery of the cell to generate antigenic peptides which can be loaded onto MHC class I molecules for surveillance by CD8+T cells of the immune system. Most
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::11d488c4823919d454a854b75be26829
https://doi.org/10.1101/2022.02.25.482016
https://doi.org/10.1101/2022.02.25.482016
Autor:
Matheswaran Kandasamy, Dawn Shepherd, Jonathan D. Silk, Eugene Shenderov, Gennaro Prota, James S. Gibbs, Uzi Gileadi, Vincenzo Cerundolo, Ji-Li Chen, Jonathan W. Yewdell
Publikováno v:
Journal for Immunotherapy of Cancer
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 6 (2021)
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 6 (2021)
BackgroundNY-ESO-1 is a tumor-specific, highly immunogenic, human germ cell antigen of the MAGE-1 family that is a promising vaccine and cell therapy candidate in clinical trial development. The mouse genome does not encode an NY-ESO-1 homolog thereb
Autor:
Adrian B. McDermott, Adam K. Wheatley, Gregory M. Frank, Suman R. Das, Heather D. Hickman, Jonathan W. Yewdell, Ivan Kosik, Davide Angeletti, Matthew Angel, Madhu Prabhakaran, David J. Leggat, James S. Gibbs
Publikováno v:
Nature immunology
Immunodominance defines the hierarchical immune response to competing antigens in complex immunogens. Little is known regarding B cell and antibody immunodominance despite its importance to immunity to viruses and other pathogens. We show that B cell
Autor:
Martha I. Nelson, Seth J. Zost, Ivan Kosik, Scott E. Hensley, Meghan O. Altman, Jonathan W. Yewdell, Matthew Angel, James S. Gibbs, Nídia S. Trovão, Lorenzo Casalino, Rommie E. Amaro
Publikováno v:
mBio, Vol 10, Iss 2, p e00204-19 (2019)
mBio, Vol 10, Iss 2 (2019)
mBio
mBio, Vol 10, Iss 2 (2019)
mBio
Frequent mutation of its major antibody target, the glycoprotein hemagglutinin, ensures that the influenza virus is perennially both a rapidly emerging virus and a major threat to public health. One type of mutation escapes immunity by adding a glyca
Autor:
Pierre Faou, Jonathan W. Yewdell, Sara Oveissi, Mubing Duan, Ian G. Barr, Daniel Dlugolenski, John Stambas, Lenny Izzard, Jack R. Bennink, Damien Zanker, Nicole A. Mifsud, Benoît Van den Eynde, Siyuan Wan, David C. Tscharke, Xiaomu Zhang, Nathalie Vigneron, James S. Gibbs, Karen L. Laurie, Weisan Chen, Kun Xiao
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950), Vol. 202, no.12, p. 3370-3380 (2019)
J Immunol
J Immunol
The importance of antiviral CD8+ T cell recognition of alternative reading frame (ARF)–derived peptides is uncertain. In this study, we describe an epitope (NS1-ARF21–8) present in a predicted 14-residue peptide encoded by the +1 register of NS1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d00c7fe608addc95f93301d3bec74373
https://hdl.handle.net/2078.1/227231
https://hdl.handle.net/2078.1/227231
Publikováno v:
Methods in Molecular Biology ISBN: 9781493995929
This chapter provides methods for the propagation, purification, and titration of vaccinia virus (VACV) and the highly attenuated strain-modified vaccinia Ankara (MVA). Additionally, we provide information on VACV recombinants we have used for intrav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a56865dedb35abddefab3f00c3860d19
https://doi.org/10.1007/978-1-4939-9593-6_18
https://doi.org/10.1007/978-1-4939-9593-6_18
Autor:
John P. Vasilakos, Rafiq Nabi, Dan H. Barouch, Yevgeniy Kovalenkov, Sudhir Pai Kasturi, Pamela A. Kozlowski, Traci Legere, Bali Pulendran, Jonathan W. Yewdell, David C. Montefiori, Jens Wrammert, James S. Gibbs, Parin Patel, Lori M. Spicer, Mark A. Tomai, Pradeep B. J. Reddy, Eric Hunter, Barton F. Haynes, C. Yong Kang, Clare F. Quarnstrom, David Masopust, Caroline Petitdemange, Cynthia A. Derdeyn, Celia C. LaBranche, Francois Villinger, Rama Rao Amara
Publikováno v:
JCI insight. 4(4)
Antibodies and cytotoxic T cells represent 2 arms of host defense against pathogens. We hypothesized that vaccines that induce both high-magnitude CD8(+) T cell responses and antibody responses might confer enhanced protection against HIV. To test th