Zobrazeno 1 - 10
of 84
pro vyhledávání: '"James S Gibbs"'
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Tissue-resident memory (TRM) CD8+ T cells are largely derived from recently activated effector T cells, but the mechanisms that control the extent of TRM differentiation within tissue microenvironments remain unresolved. Here, using an IFNγ
Externí odkaz:
https://doaj.org/article/98659d4192e840ac935c48162957b947
Autor:
Meghan O. Altman, Matthew Angel, Ivan Košík, Nídia S. Trovão, Seth J. Zost, James S. Gibbs, Lorenzo Casalino, Rommie E. Amaro, Scott E. Hensley, Martha I. Nelson, Jonathan W. Yewdell
Publikováno v:
mBio, Vol 10, Iss 2 (2019)
ABSTRACT Human antibody-based immunity to influenza A virus is limited by antigenic drift resulting from amino acid substitutions in the hemagglutinin (HA) head domain. Glycan addition can cause large antigenic changes but is limited by fitness costs
Externí odkaz:
https://doaj.org/article/b7c5ac3ce6cf49fcb5e61be2761289cd
Autor:
Kartikeya Vijayasimha, Amy L. Leestemaker-Palmer, James S. Gibbs, Jonathan W. Yewdell, Brian P. Dolan
Successful direct MHC class I antigen presentation is dependent on the protein degradation machinery of the cell to generate antigenic peptides which can be loaded onto MHC class I molecules for surveillance by CD8+T cells of the immune system. Most
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::11d488c4823919d454a854b75be26829
https://doi.org/10.1101/2022.02.25.482016
https://doi.org/10.1101/2022.02.25.482016
Autor:
Gregory M. Frank, Davide Angeletti, William L. Ince, James S. Gibbs, Surender Khurana, Adam K. Wheatley, Edward E. Max, Adrian B. McDermott, Hana Golding, James Stevens, Jack R. Bennink, Jonathan W. Yewdell
Publikováno v:
mBio, Vol 6, Iss 4 (2015)
ABSTRACT Antibody (Ab) affinity maturation enables an individual to maintain immunity to an increasing number of pathogens within the limits of a total Ig production threshold. A better understanding of this process is critical for designing vaccines
Externí odkaz:
https://doaj.org/article/b5878bacd8b24a17bf9b60102e41b1e6
Autor:
Matheswaran Kandasamy, Dawn Shepherd, Jonathan D. Silk, Eugene Shenderov, Gennaro Prota, James S. Gibbs, Uzi Gileadi, Vincenzo Cerundolo, Ji-Li Chen, Jonathan W. Yewdell
Publikováno v:
Journal for Immunotherapy of Cancer
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 6 (2021)
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 6 (2021)
BackgroundNY-ESO-1 is a tumor-specific, highly immunogenic, human germ cell antigen of the MAGE-1 family that is a promising vaccine and cell therapy candidate in clinical trial development. The mouse genome does not encode an NY-ESO-1 homolog thereb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e386e910e2565cc4ef2096f372cd07da
http://europepmc.org/articles/PMC8183295
http://europepmc.org/articles/PMC8183295
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e33072 (2012)
Aminoacyl-tRNA synthetases (ARSs) are critical components of protein translation, providing ribosomes with aminoacyl-tRNAs. In return, ribosomes release uncharged tRNAs as ARS substrates. Here, we show that tRNA deacylation can be uncoupled from prot
Externí odkaz:
https://doaj.org/article/39f23fdb734e429e90f254385b527ba4
Autor:
Scott E Hensley, Suman R Das, James S Gibbs, Adam L Bailey, Loren M Schmidt, Jack R Bennink, Jonathan W Yewdell
Publikováno v:
PLoS ONE, Vol 6, Iss 2, p e15190 (2011)
Drugs inhibiting the influenza A virus (IAV) neuraminidase (NA) are the cornerstone of anti-IAV chemotherapy and prophylaxis in man. Drug-resistant mutations in NA arise frequently in human isolates, limiting the therapeutic application of NA inhibit
Externí odkaz:
https://doaj.org/article/a2918f031411439db2d136499f4de716
Autor:
Adrian B. McDermott, Adam K. Wheatley, Gregory M. Frank, Suman R. Das, Heather D. Hickman, Jonathan W. Yewdell, Ivan Kosik, Davide Angeletti, Matthew Angel, Madhu Prabhakaran, David J. Leggat, James S. Gibbs
Publikováno v:
Nature immunology
Immunodominance defines the hierarchical immune response to competing antigens in complex immunogens. Little is known regarding B cell and antibody immunodominance despite its importance to immunity to viruses and other pathogens. We show that B cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d427be2a48c081610fa57743dacf568
https://doi.org/10.1038/ni.3680
https://doi.org/10.1038/ni.3680
Autor:
Martha I. Nelson, Seth J. Zost, Ivan Kosik, Scott E. Hensley, Meghan O. Altman, Jonathan W. Yewdell, Matthew Angel, James S. Gibbs, Nídia S. Trovão, Lorenzo Casalino, Rommie E. Amaro
Publikováno v:
mBio, Vol 10, Iss 2, p e00204-19 (2019)
mBio, Vol 10, Iss 2 (2019)
mBio
mBio, Vol 10, Iss 2 (2019)
mBio
Frequent mutation of its major antibody target, the glycoprotein hemagglutinin, ensures that the influenza virus is perennially both a rapidly emerging virus and a major threat to public health. One type of mutation escapes immunity by adding a glyca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ebb465768711f20beaa1abc942a7cd5
https://doi.org/10.1128/mbio.00204-19
https://doi.org/10.1128/mbio.00204-19
Autor:
Pierre Faou, Jonathan W. Yewdell, Sara Oveissi, Mubing Duan, Ian G. Barr, Daniel Dlugolenski, John Stambas, Lenny Izzard, Jack R. Bennink, Damien Zanker, Nicole A. Mifsud, Benoît Van den Eynde, Siyuan Wan, David C. Tscharke, Xiaomu Zhang, Nathalie Vigneron, James S. Gibbs, Karen L. Laurie, Weisan Chen, Kun Xiao
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950), Vol. 202, no.12, p. 3370-3380 (2019)
J Immunol
J Immunol
The importance of antiviral CD8+ T cell recognition of alternative reading frame (ARF)–derived peptides is uncertain. In this study, we describe an epitope (NS1-ARF21–8) present in a predicted 14-residue peptide encoded by the +1 register of NS1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d00c7fe608addc95f93301d3bec74373
https://hdl.handle.net/2078.1/227231
https://hdl.handle.net/2078.1/227231