Zobrazeno 1 - 10
of 17
pro vyhledávání: '"James S Bean"'
Autor:
Melissa A Bellinger, James S Bean, Melissa A Rader, Kathleen M Heinz-Taheny, Jairo S Nunes, Joseph V Haas, Laura F Michael, Mark D Rekhter
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e93297 (2014)
BACKGROUND: Acute kidney injury (AKI) is a syndrome characterized by the rapid loss of the kidney excretory function and is strongly associated with increased early and long-term patient morbidity and mortality. Early diagnosis of AKI is challenging;
Externí odkaz:
https://doaj.org/article/ed5393dd682c48c7a0d43188c1bf53c0
Autor:
Richard G Conway, Eyassu Chernet, David C De Rosa, Robert J Benschop, Anne B Need, Emily C Collins, James S Bean, J Michael Kalbfleisch, Mark D Rekhter
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e50349 (2012)
(18)F-Fluorodeoxyglucose (FDG)-positron emission tomography (PET) imaging of atherosclerosis in the clinic is based on preferential accumulation of radioactive glucose analog in atherosclerotic plaques. FDG-PET is challenging in mouse models due to l
Externí odkaz:
https://doaj.org/article/f41871f555ec4207b4e3c75e279b22fc
Autor:
Sherif Khedr, Alexander Staruschenko, Tamika D. Meredith, Xin Zhou, Kevin Michael Ruley, Mark C. Kowala, Mark David Rekhter, Simon J. Atkinson, Cynthia Darshini Jesudason, James S. Bean, Asim Bikash Dey, Maia Terashvili, Leah L. Porras, Michael Robert Wiley, Joseph V Hass, Francis S. Willard
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
Regulation of the peripheral vascular resistance via modulating the vessel diameter has been considered as a main determinant of the arterial blood pressure. Phosphodiesterase enzymes (PDE1-11) hydrolyse cyclic nucleotides, which are key players cont
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cc450082f3d8361a4672e819296a7b7
https://doi.org/10.3389/fphys.2020.543727
https://doi.org/10.3389/fphys.2020.543727
Autor:
Matthew W. Carson, Robert J. Barr, Dana Sindelar, Daniel Timothy Kohlman, Bradley Condon, David K. Clawson, A. Pustilnik, M. Joelle Dill, James S. Bean, John G. Luz, Michael J. Coghlan, Milan Maletic
Publikováno v:
Journal of Medicinal Chemistry. 58:6607-6618
To further elucidate the structural activity correlation of glucocorticoid receptor (GR) antagonism, the crystal structure of the GR ligand-binding domain (GR LBD) complex with a nonsteroidal antagonist, compound 8, was determined. This novel indole
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05523d9b3d43e70486cf70fa19d94a56
https://doi.org/10.1021/acs.jmedchem.5b00736
https://doi.org/10.1021/acs.jmedchem.5b00736
Autor:
James S. Bean, Nathan Bryan Mantlo, Pam McClelland, Raymond F. Kauffman, Guoming Wang, Jai Pal Singh, Chahrzad Montrose, Asavari Wagle, William R. Bensch
Publikováno v:
Molecular Pharmacology. 68:763-768
Low high-density lipoprotein-cholesterol (HDL-c) is an important risk factor of coronary artery disease (CAD). Optimum therapy for raising HDL-c is still not available. Identification of novel HDL-raising agents would produce a major impact on CAD. I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b644f836e10ddc2144b958c06092762
https://doi.org/10.1124/mol.105.010991
https://doi.org/10.1124/mol.105.010991
Autor:
Sha Liu, Raymond F. Kauffman, Garret J. Etgen, Dale E. Mais, Allie Edward Tripp, Chahrzad Montrose-Rafizadeh, Yanping Xu, Leonard L. Winneroski, Brian A. Oldham, Patric James Hahn, Deepa Rungta, Dawn A. Brooks, William R. Bensch, Mary K. Peters, Sarah B. Wilson, Kathy M Ogilvie, Mccarthy James R, Jacob R Bosley, Samuel J. Dominianni, Christopher John Rito, Richard W. Zink, Robert J. Ardecky, James S. Bean, Anthony J. Shuker, Carol L. Broderick, Gregory A. Stephenson
Publikováno v:
Journal of Medicinal Chemistry. 47:2422-2425
The design and synthesis of the dual peroxisome proliferator activated receptor (PPAR) alpha/gamma agonist (S)-2-methyl-3-[4-[2-(5-methyl-2-thiophen-2-yl-oxazol-4-yl)ethoxy]phenyl]-2-phenoxypropionic acid (2) for the treatment of type 2 diabetes and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1308bb3472bf950182ed5ac246acab95
https://doi.org/10.1021/jm0342616
https://doi.org/10.1021/jm0342616
Autor:
James R. Paterniti, James M. Bilakovics, Mccarthy James R, William R. Bensch, Joseph T. Brozinick, Brian A. Oldham, Garret J. Etgen, Kathleen M. Ogilvie, Sha Liu, Christopher John Rito, Carol L. Broderick, Anthony J. Shuker, Robert J. Ardecky, James S. Bean, Elizabeth A. Misener, John S. Tyhonas, Sharon L. Dana, William T. Johnson, Dawn A. Brooks, Raymond F. Kauffman, Chahrzad R. Montrose
Publikováno v:
Diabetes. 51:1083-1087
A novel nonthiazolidinedione dual peroxisome proliferator- activated receptor (PPAR)-α/γ agonist, LY465608, was designed to address the major metabolic disturbances of type 2 diabetes. LY465608 altered PPAR-responsive genes in liver and fat of db/d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b450b25eeadc156ea632676a20dd572
https://doi.org/10.2337/diabetes.51.4.1083
https://doi.org/10.2337/diabetes.51.4.1083
Autor:
Mark David Rekhter, Jairo S. Nunes, Laura F. Michael, James S. Bean, Kathleen M. Heinz-Taheny, Joseph V. Haas, Melissa A. Bellinger, Melissa A. Rader
Publikováno v:
PLoS ONE
PLoS ONE, Vol 9, Iss 4, p e93297 (2014)
PLoS ONE, Vol 9, Iss 4, p e93297 (2014)
BACKGROUND: Acute kidney injury (AKI) is a syndrome characterized by the rapid loss of the kidney excretory function and is strongly associated with increased early and long-term patient morbidity and mortality. Early diagnosis of AKI is challenging;
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d71c66053b870a83815eec5eb1de8cee
https://pubmed.ncbi.nlm.nih.gov/24695114
https://pubmed.ncbi.nlm.nih.gov/24695114
Autor:
David C. De Rosa, Robert J. Benschop, Emily C. Collins, Conway Richard Gerard, Eyassu Chernet, Mark David Rekhter, Anne B. Need, James S. Bean, J. Michael Kalbfleisch
Publikováno v:
PLoS ONE
PLoS ONE, Vol 7, Iss 11, p e50349 (2012)
PLoS ONE, Vol 7, Iss 11, p e50349 (2012)
Background 18F-Fluorodeoxyglucose (FDG)-positron emission tomography (PET) imaging of atherosclerosis in the clinic is based on preferential accumulation of radioactive glucose analog in atherosclerotic plaques. FDG-PET is challenging in mouse models
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99283ba06ce3a2fcaf5687d7b122a47d
http://europepmc.org/articles/PMC3508896
http://europepmc.org/articles/PMC3508896
Autor:
James Schrementi, Jian Wang, Chen-Shian Suen, Yue-Wei Qian, He Wang, Ming-Shang Kuo, Guoqing Cao, Yunling Gao, Regina K. Porter, James S. Bean, Raymond F. Kauffman, David A Yurek, Lan Yu
Publikováno v:
Lipids. 43(3)
Stearoyl-CoA desaturase (SCD) catalyzes the formation of monounsaturated fatty acids from saturated fatty acids. It plays a key role in lipid metabolism and energy expenditure in mammals. In mice, four SCD isoforms (SCD1–4) have been identified. He
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab518d898eaab50c906b5c9423e8c2b2
https://pubmed.ncbi.nlm.nih.gov/18084785
https://pubmed.ncbi.nlm.nih.gov/18084785